Effect of Supervised Progressive Resistance-Exercise Training Protocol on Insulin Sensitivity, Glycemia, Lipids, and Body Composition in Asian Indians With Type 2 Diabetes

OBJECTIVE:--To evaluate the effect of supervised progressive resistance-exercise training (PRT) protocol on insulin sensitivity, glycemia (blood glucose and A1C levels), lipids, and body composition in Asian Indians with type 2 diabetes. RESEARCH DESIGN AND METHODS--Thirty patients with type 2 diabe...

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Veröffentlicht in:	Diabetes care Jg. 31; H. 7; S. 1282 - 1287
Hauptverfasser:	Misra, Anoop, Alappan, Narendra K, Vikram, Naval K, Goel, Kashish, Gupta, Nidhi, Mittal, Kanchan, Bhatt, Suryaprakash, Luthra, Kalpana
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Alexandria, VA American Diabetes Association 01.07.2008
Schlagworte:	Absorptiometry, Photon adipose tissue Adult anatomy & histology Asian Indians Biological and medical sciences blood blood glucose Blood Glucose - drug effects Blood Glucose - metabolism blood serum Blood sugar Body Composition body fat body mass index C-reactive protein cholesterol Cholesterol - blood Clinical Care/Education/Nutrition/Psychosocial Research computed tomography Control Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance drug effects dual-energy X-ray absorptiometry Endocrine pancreas. Apud cells (diseases) Endocrinopathies epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Exercise fasting Female glucose Humans India Insulin Insulin - metabolism Insulin - pharmacology Insulin - physiology Insulin Resistance Insulin Secretion insulin tolerance test lean body mass Lipids Lipids - blood Lipoproteins Lipoproteins - blood Male Measurement Medical sciences Metabolic diseases metabolism Middle Aged Miscellaneous Muscle, Skeletal Muscle, Skeletal - anatomy & histology Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - physiopathology noninsulin-dependent diabetes mellitus patients pharmacology Physiological aspects physiology physiopathology Prevention Public health. Hygiene Public health. Hygiene-occupational medicine radiography Risk factors secretion skeletal muscle strength training Tomography, X-Ray Computed triacylglycerols Type 2 diabetes Asia India Endocrinopathy Type 2 diabetes Physical exercise Human Pancreatic hormone Asiatic Nutrition Insulin sensitivity Lipids Metabolic diseases Insulin Body composition Indian Endocrinology Glycemia
ISSN:	0149-5992, 1935-5548, 1935-5548
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Zusammenfassung:	OBJECTIVE:--To evaluate the effect of supervised progressive resistance-exercise training (PRT) protocol on insulin sensitivity, glycemia (blood glucose and A1C levels), lipids, and body composition in Asian Indians with type 2 diabetes. RESEARCH DESIGN AND METHODS--Thirty patients with type 2 diabetes underwent 12 weeks of PRT of six muscle groups (two sets, 10 repetitions each). The subjects were evaluated with detailed anthropometry and with measurements of the disappearance of glucose per unit time (K) during the short insulin tolerance test (KITT) for assessment of insulin sensitivity; of fasting blood glucose, A1C, lipids, and high-sensitivity C-reactive protein (hsCRP); of total body fat, regional fat, and lean body mass by dual-energy X-ray absorptiometry; and of cross-sectional skeletal muscle area of upper arm and thigh by computed tomography scan. RESULTS:--Insulin sensitivity improved significantly from mean ± SD KITT 1.22 ± 0.73 to 2.13 ± 0.75 (P < 0.0001) after the intervention. Significant decline (mean difference ± SD) from baseline was recorded in levels of the following parameters: A1C (0.54 ± 0.4%, P < 0.001), fasting blood glucose (2.7 ± 2.2 mmol/l, P < 0.001), total cholesterol (0.39 ± 0.7 mmol/l, P = 0.003), serum triglycerides (0.39 ± 0.5 mmol/l, P < 0.001), and truncal and peripheral subcutaneous adipose tissue compartments (SCAT) (P < 0.001). However, no significant changes were noticed in BMI or levels of total body fat, truncal fat, lean body mass, cross-sectional skeletal muscle area of the extremities, or hsCRP levels. CONCLUSIONS:--Moderate-intensity PRT for 3 months resulted in significant improvement in insulin sensitivity, glycemia, lipids, and truncal and peripheral SCAT in patients with type 2 diabetes. Resistance training should be an integral part of exercise regimen in Asian Indians with type 2 diabetes.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author: Anoop Misra, anoopmisra@metabolicresearchindia.com Published ahead of print at http://care.diabetesjournals.org on 3 March 2008. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
ISSN:	0149-5992 1935-5548 1935-5548
DOI:	10.2337/dc07-2316