The screening value of RT-LAMP and RT-PCR in the diagnosis of COVID-19: systematic review and meta-analysis

•RT-PCR and RT-LAMP are widely used; however false negative rate (FNR) are 6% ∼ 12 %.•Sensitivity and FNR of index test were significantly affected by the reference method.•PCR is not the perfect gold standard for comparison of diagnostic accuracy with COVID-19.•Performance of RT-LAMP may be exagger...

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Bibliographic Details
Published in:	Journal of virological methods Vol. 300; p. 114392
Main Authors:	Pu, Ruiyang, Liu, Sha, Ren, Xiaoyu, Shi, Dian, Ba, Yupei, Huo, Yanbei, Zhang, Wenling, Ma, Lingling, Liu, Yanyan, Yang, Yan, Cheng, Ning
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.02.2022
Subjects:	COVID-19 COVID-19 infection Diagnostic accuracy disease diagnosis False-negative rate genes Humans meta-analysis Molecular Diagnostic Techniques Nucleic Acid Amplification Techniques Reverse Transcriptase Polymerase Chain Reaction Reverse Transcription reverse transcription loop-mediated isothermal amplification RT-LAMP RT-PCR SARS-CoV-2 Sensitivity and Specificity Severe acute respiratory syndrome coronavirus 2 systematic review COVID-19 RT-LAMP False-negative rate Diagnostic accuracy RT-PCR
ISSN:	0166-0934, 1879-0984, 1879-0984
Online Access:	Get full text
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