Capsazepine prolongation of the duration of lidocaine block of sensory transmission in mice may be mediated by modulation of HCN channel currents

Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels contribute to the effects of lidocaine. Capsazepine (CPZ), a competitive inhibitor of capsaicin of transient receptor potential vanilloid-1 channel, has also been found to inhibit HCN channel currents ( ). This study was designed to...

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Bibliographic Details
Published in:	PeerJ (San Francisco, CA) Vol. 7; p. e7111
Main Authors:	Zhao, Wenling, Liang, Peng, Liu, Jin, Li, Huan, Liao, Daqing, Chen, Xiangdong, Li, Qian, Zhou, Cheng
Format:	Journal Article
Language:	English
Published:	United States PeerJ. Ltd 13.06.2019 PeerJ, Inc PeerJ Inc
Subjects:	Adenosine monophosphate Analysis Anesthesia Anesthesiology Anesthesiology and Pain Management Capsaicin Capsazepine Central nervous system agents Cyclic adenosine monophosphate Cyclic AMP Cyclin-dependent kinases Dexmedetomidine Dorsal root ganglia Forskolin Ganglion cysts Hospitals Hyperpolarization Ion channels (cyclic nucleotide-gated) Kinases Laboratories Lidocaine Local anesthetics Medical research Medicine Neurology Neurons Neuroscience Pain Peripheral nerves Phenols (Class of compounds) Regional anesthesia Sciatic nerve Sodium channels (voltage-gated) Transient receptor potential proteins United States > US China Capsazepine Regional anesthesia Local anesthetics
ISSN:	2167-8359, 2167-8359
Online Access:	Get full text
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