Pregnancy Is Associated with Impaired Transcription of Human Endogenous Retroviruses and of TRIM28 and SETDB1, Particularly in Mothers Affected by Multiple Sclerosis

Accumulating evidence highlights the pathogenetic role of human endogenous retroviruses (HERVs) in eliciting and maintaining multiple sclerosis (MS). Epigenetic mechanisms, such as those regulated by TRIM 28 and SETDB1, are implicated in HERV activation and in neuroinflammatory disorders, including...

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Bibliographic Details
Published in:	Viruses Vol. 15; no. 3; p. 710
Main Authors:	Tovo, Pier-Angelo, Marozio, Luca, Abbona, Giancarlo, Calvi, Cristina, Frezet, Federica, Gambarino, Stefano, Dini, Maddalena, Benedetto, Chiara, Galliano, Ilaria, Bergallo, Massimiliano
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 09.03.2023 MDPI
Subjects:	Autoimmune diseases blood Care and treatment Chorion Cord blood Cytokines Decidua Diagnosis Disease DNA methylation Endogenous Retroviruses - genetics Epigenesis, Genetic Epigenetics Female Genes, env Genomes Gestation Health aspects Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism human endogenous retroviruses Humans Infant, Newborn Inflammation Medical innovations Mothers Multiple Sclerosis Neonates pathogenesis Peripheral blood Placenta polymerase chain reaction Pregnancy Pregnancy Complications Pregnant women Proteins Retroviridae RNA, Messenger sclerosis SETDB1 Syncytin Therapeutic applications therapeutics transcription (genetics) TRIM28 Tripartite Motif-Containing Protein 28 - genetics Tripartite Motif-Containing Protein 28 - metabolism Womens health Italy United States > US SETDB1 TRIM28 human endogenous retroviruses multiple sclerosis pregnancy
ISSN:	1999-4915, 1999-4915
Online Access:	Get full text
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