Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be fundamentally important, yet remains obscure. We tested the hypothesis that germ‐free (GF) mutltidrug resistance 2 knockout (mdr2−/−) mice develo...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 63; no. 1; pp. 185 - 196
Main Authors:	Tabibian, James H., O'Hara, Steven P., Trussoni, Christy E., Tietz, Pamela S., Splinter, Patrick L., Mounajjed, Taofic, Hagey, Lee R., LaRusso, Nicholas F.
Format:	Journal Article
Language:	English
Published:	United States Wolters Kluwer Health, Inc 01.01.2016
Subjects:	Acids Alkaline phosphatase Animal models Animals Aspartate aminotransferase Bile Bile acids Bilirubin Cholangitis Cholangitis, Sclerosing - etiology Disease Models, Animal Disease Progression Embryo transfer Female Fibrosis Gallbladder Gastrointestinal Microbiome - physiology Germfree Hepatology Hydroxyproline Immunofluorescence INK4a protein Intestinal microflora Intestine Liver Male Metabolites Mice Mice, Knockout Morphometry p16 Protein Rodents Senescence Therapeutic applications Ursodeoxycholic acid β-Galactosidase
ISSN:	0270-9139, 1527-3350
Online Access:	Get full text
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