Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

Despite the widespread interest in direct neuronal reprogramming, the mechanisms underpinning fate conversion remain largely unknown. Our study revealed a critical time point after which cells either successfully convert into neurons or succumb to cell death. Co-transduction with Bcl-2 greatly impro...

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Veröffentlicht in:	Cell stem cell Jg. 18; H. 3; S. 396 - 409
Hauptverfasser:	Gascón, Sergio, Murenu, Elisa, Masserdotti, Giacomo, Ortega, Felipe, Russo, Gianluca L, Petrik, David, Deshpande, Aditi, Heinrich, Christophe, Karow, Marisa, Robertson, Stephen P, Schroeder, Timm, Beckers, Johannes, Irmler, Martin, Berndt, Carsten, Angeli, José P Friedmann, Conrad, Marcus, Berninger, Benedikt, Götz, Magdalena
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 03.03.2016
Schlagworte:	Animals Cellular Reprogramming Cellular Reprogramming Techniques Mice Neuroglia - cytology Neuroglia - metabolism Neurons - cytology Neurons - metabolism Oxidative Stress Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Transduction, Genetic
ISSN:	1875-9777
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