Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis

The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts f...

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Vydané v:	The European respiratory journal Ročník 45; číslo 1; s. 38
Hlavní autori:	Adam, Martin, Schikowski, Tamara, Carsin, Anne Elie, Cai, Yutong, Jacquemin, Benedicte, Sanchez, Margaux, Vierkötter, Andrea, Marcon, Alessandro, Keidel, Dirk, Sugiri, Dorothee, Al Kanani, Zaina, Nadif, Rachel, Siroux, Valérie, Hardy, Rebecca, Kuh, Diana, Rochat, Thierry, Bridevaux, Pierre-Olivier, Eeftens, Marloes, Tsai, Ming-Yi, Villani, Simona, Phuleria, Harish Chandra, Birk, Matthias, Cyrys, Josef, Cirach, Marta, de Nazelle, Audrey, Nieuwenhuijsen, Mark J, Forsberg, Bertil, de Hoogh, Kees, Declerq, Christophe, Bono, Roberto, Piccioni, Pavilio, Quass, Ulrich, Heinrich, Joachim, Jarvis, Deborah, Pin, Isabelle, Beelen, Rob, Hoek, Gerard, Brunekreef, Bert, Schindler, Christian, Sunyer, Jordi, Krämer, Ursula, Kauffmann, Francine, Hansell, Anna L, Künzli, Nino, Probst-Hensch, Nicole
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.01.2015
Predmet:	Adult Aged Air Pollutants - analysis Air Pollution - adverse effects Environmental Exposure Environmental Monitoring - methods Europe Female Forced Expiratory Volume Humans Lung - physiopathology Male Middle Aged Multicenter Studies as Topic Nitrogen Oxides - chemistry Particulate Matter Respiratory Physiological Phenomena Europe
ISSN:	1399-3003, 1399-3003
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Abstract	The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO₂, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m(-3) increase in NO₂ exposure was associated with lower levels of FEV₁ (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m(-3) in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV₁ (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI -112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
AbstractList	The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO₂, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m(-3) increase in NO₂ exposure was associated with lower levels of FEV₁ (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m(-3) in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV₁ (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI -112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe. The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO₂, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m(-3) increase in NO₂ exposure was associated with lower levels of FEV₁ (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m(-3) in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV₁ (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI -112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO₂, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m(-3) increase in NO₂ exposure was associated with lower levels of FEV₁ (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m(-3) in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV₁ (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI -112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
Author	Marcon, Alessandro Eeftens, Marloes Cirach, Marta Vierkötter, Andrea Piccioni, Pavilio Tsai, Ming-Yi Pin, Isabelle Carsin, Anne Elie Cai, Yutong Jacquemin, Benedicte Heinrich, Joachim Phuleria, Harish Chandra Cyrys, Josef Rochat, Thierry Sanchez, Margaux Kuh, Diana Keidel, Dirk Forsberg, Bertil Probst-Hensch, Nicole Schikowski, Tamara Sunyer, Jordi Krämer, Ursula Nieuwenhuijsen, Mark J Kauffmann, Francine Adam, Martin Sugiri, Dorothee Hardy, Rebecca Beelen, Rob Declerq, Christophe Künzli, Nino Siroux, Valérie Villani, Simona Jarvis, Deborah Hansell, Anna L Quass, Ulrich Bridevaux, Pierre-Olivier de Nazelle, Audrey Al Kanani, Zaina Schindler, Christian Brunekreef, Bert de Hoogh, Kees Bono, Roberto Hoek, Gerard Birk, Matthias Nadif, Rachel
Author_xml	– sequence: 1 givenname: Martin surname: Adam fullname: Adam, Martin organization: Swiss Tropical and Public Health Institute, Basel University of Basel, Basel These authors contributed equally – sequence: 2 givenname: Tamara surname: Schikowski fullname: Schikowski, Tamara organization: Swiss Tropical and Public Health Institute, Basel University of Basel, Basel Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf These authors contributed equally – sequence: 3 givenname: Anne Elie surname: Carsin fullname: Carsin, Anne Elie organization: Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain These authors contributed equally – sequence: 4 givenname: Yutong surname: Cai fullname: Cai, Yutong organization: MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London – sequence: 5 givenname: Benedicte surname: Jacquemin fullname: Jacquemin, Benedicte organization: Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, Villejuif Univ. Paris-Sud, UMRS 1018, Villejuif – sequence: 6 givenname: Margaux surname: Sanchez fullname: Sanchez, Margaux organization: Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, Villejuif Univ. Paris-Sud, UMRS 1018, Villejuif – sequence: 7 givenname: Andrea surname: Vierkötter fullname: Vierkötter, Andrea organization: Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf – sequence: 8 givenname: Alessandro surname: Marcon fullname: Marcon, Alessandro organization: Unit of Epidemiology and Medical Statistics, Dept of Public Health and Community Medicine, University of Verona, Verona – sequence: 9 givenname: Dirk surname: Keidel fullname: Keidel, Dirk organization: Swiss Tropical and Public Health Institute, Basel University of Basel, Basel – sequence: 10 givenname: Dorothee surname: Sugiri fullname: Sugiri, Dorothee organization: Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf – sequence: 11 givenname: Zaina surname: Al Kanani fullname: Al Kanani, Zaina organization: MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London – sequence: 12 givenname: Rachel surname: Nadif fullname: Nadif, Rachel organization: Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, Villejuif Univ. Paris-Sud, UMRS 1018, Villejuif – sequence: 13 givenname: Valérie surname: Siroux fullname: Siroux, Valérie organization: Inserm U823, Environmental Epidemiology Applied to Reproduction and Respiratory Health Team, Grenoble Univ. Joseph Fourier, Grenoble – sequence: 14 givenname: Rebecca surname: Hardy fullname: Hardy, Rebecca organization: MRC University Unit for Lifelong Health and Ageing, University College London, London – sequence: 15 givenname: Diana surname: Kuh fullname: Kuh, Diana organization: MRC University Unit for Lifelong Health and Ageing, University College London, London – sequence: 16 givenname: Thierry surname: Rochat fullname: Rochat, Thierry organization: Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva, Switzerland – sequence: 17 givenname: Pierre-Olivier surname: Bridevaux fullname: Bridevaux, Pierre-Olivier organization: Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva, Switzerland – sequence: 18 givenname: Marloes surname: Eeftens fullname: Eeftens, Marloes organization: Swiss Tropical and Public Health Institute, Basel University of Basel, Basel Institute for Risk Assessment Sciences, Utrecht University, Utrecht – sequence: 19 givenname: Ming-Yi surname: Tsai fullname: Tsai, Ming-Yi organization: Swiss Tropical and Public Health Institute, Basel University of Basel, Basel – sequence: 20 givenname: Simona surname: Villani fullname: Villani, Simona organization: Unit of Biostatistics and Clinical Epidemiology Dept of Public Health, Experimental and Forensic Medicine University of Pavia, Pavia – sequence: 21 givenname: Harish Chandra surname: Phuleria fullname: Phuleria, Harish Chandra organization: Swiss Tropical and Public Health Institute, Basel University of Basel, Basel – sequence: 22 givenname: Matthias surname: Birk fullname: Birk, Matthias organization: Helmholtz Zentrum, München and German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg – sequence: 23 givenname: Josef surname: Cyrys fullname: Cyrys, Josef organization: Helmholtz Zentrum, München and German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg Environmental Science Center, University Augsburg, Augsburg – sequence: 24 givenname: Marta surname: Cirach fullname: Cirach, Marta organization: Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain – sequence: 25 givenname: Audrey surname: de Nazelle fullname: de Nazelle, Audrey organization: Centre for Environmental Policy, Imperial College London, London – sequence: 26 givenname: Mark J surname: Nieuwenhuijsen fullname: Nieuwenhuijsen, Mark J organization: Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain – sequence: 27 givenname: Bertil surname: Forsberg fullname: Forsberg, Bertil organization: Environmental and Occupational Medicine, Dept of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden – sequence: 28 givenname: Kees surname: de Hoogh fullname: de Hoogh, Kees organization: MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London – sequence: 29 givenname: Christophe surname: Declerq fullname: Declerq, Christophe organization: French Institute for Public Health Surveillance, Saint-Maurice – sequence: 30 givenname: Roberto surname: Bono fullname: Bono, Roberto organization: Dept of Public Health and Pediatrics, University of Turin, Turin – sequence: 31 givenname: Pavilio surname: Piccioni fullname: Piccioni, Pavilio organization: SC Pneumologia CPA ASL 4 Turin, Turin, Italy – sequence: 32 givenname: Ulrich surname: Quass fullname: Quass, Ulrich organization: Air Quality and Sustainable Nanotechnology, IUTA Institut für Energie- und Umwelttechnik e.V., Duisburg, Germany – sequence: 33 givenname: Joachim surname: Heinrich fullname: Heinrich, Joachim organization: Helmholtz Zentrum, München and German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg – sequence: 34 givenname: Deborah surname: Jarvis fullname: Jarvis, Deborah organization: MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London Dept of Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College London, London – sequence: 35 givenname: Isabelle surname: Pin fullname: Pin, Isabelle organization: Inserm U823, Environmental Epidemiology Applied to Reproduction and Respiratory Health Team, Grenoble Univ. Joseph Fourier, Grenoble Pédiatrie, CHU de Grenoble, La Tronche, France – sequence: 36 givenname: Rob surname: Beelen fullname: Beelen, Rob organization: Institute for Risk Assessment Sciences, Utrecht University, Utrecht – sequence: 37 givenname: Gerard surname: Hoek fullname: Hoek, Gerard organization: Institute for Risk Assessment Sciences, Utrecht University, Utrecht – sequence: 38 givenname: Bert surname: Brunekreef fullname: Brunekreef, Bert organization: Institute for Risk Assessment Sciences, Utrecht University, Utrecht Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands – sequence: 39 givenname: Christian surname: Schindler fullname: Schindler, Christian organization: Swiss Tropical and Public Health Institute, Basel University of Basel, Basel – sequence: 40 givenname: Jordi surname: Sunyer fullname: Sunyer, Jordi organization: Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults – sequence: 41 givenname: Ursula surname: Krämer fullname: Krämer, Ursula organization: Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults – sequence: 42 givenname: Francine surname: Kauffmann fullname: Kauffmann, Francine organization: Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, Villejuif Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults – sequence: 43 givenname: Anna L surname: Hansell fullname: Hansell, Anna L organization: MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London Public Health and Primary Care Directorate, Imperial College Healthcare NHS Trust, London, UK Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults – sequence: 44 givenname: Nino surname: Künzli fullname: Künzli, Nino organization: Swiss Tropical and Public Health Institute, Basel University of Basel, Basel Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults – sequence: 45 givenname: Nicole surname: Probst-Hensch fullname: Probst-Hensch, Nicole email: Nicole.Probst@unibas.ch organization: Swiss Tropical and Public Health Institute, Basel University of Basel, Basel Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults Nicole.Probst@unibas.ch
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Snippet	The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association...
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SubjectTerms	Adult Aged Air Pollutants - analysis Air Pollution - adverse effects Environmental Exposure Environmental Monitoring - methods Europe Female Forced Expiratory Volume Humans Lung - physiopathology Male Middle Aged Multicenter Studies as Topic Nitrogen Oxides - chemistry Particulate Matter Respiratory Physiological Phenomena
Title	Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis
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