Preliminary Investigation of Schmalhausen’s Law in a Directly Transmitted Pathogen Outbreak System

The past few decades have been marked by drastic modifications to the landscape by anthropogenic processes, leading to increased variability in the environment. For populations that thrive at their distributional boundaries, these changes can affect them drastically, as Schmalhausen’s law predicts t...

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Vydáno v:	Viruses Ročník 15; číslo 2; s. 310
Hlavní autoři:	Filion, Antoine, Sundaram, Mekala, Stephens, Patrick R.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 22.01.2023 MDPI
Témata:	Analysis Animals Biological Evolution Communicable diseases Communication Diagnosis disease ecology disease emergence Disease Outbreaks Disease transmission ecological boundaries environmental factors Epidemics filovirus Genotype landscapes Marburg marburgvirus Marburgvirus Outbreaks Pathogens Physiology Population density Risk factors Schmalhausen’s law spillover Standard deviation Temperature Tropical diseases Variables Vector-borne diseases Vectors (Biology) Viruses Zoonoses Egypt spillover ecological boundaries disease ecology disease emergence filovirus Schmalhausen’s law
ISSN:	1999-4915, 1999-4915
On-line přístup:	Získat plný text
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Shrnutí:	The past few decades have been marked by drastic modifications to the landscape by anthropogenic processes, leading to increased variability in the environment. For populations that thrive at their distributional boundaries, these changes can affect them drastically, as Schmalhausen’s law predicts that their dynamics are more likely to be susceptible to environmental variation. Recently, this evolutionary theory has been put to the test in vector-borne disease emergences systems, and has been demonstrated effective in predicting emergence patterns. However, it has yet to be tested in a directly transmitted pathogen. Here, we provide a preliminary test of Schmalhausen’s law using data on Marburg virus outbreaks originating from spillover events. By combining the two important aspects of Schmalhausen’s law, namely climatic anomalies and distance to species distributional edges, we show that Marburgvirus outbreaks may support an aspect of this evolutionary theory, with distance to species distributional edge having a weak influence on outbreak size. However, we failed to demonstrate any effect of climatic anomalies on Marburgvirus outbreaks, arguably related to the lack of importance of these variables in directly transmitted pathogen outbreaks. With increasing zoonotic spillover events occurring from wild species, we highlight the importance of considering ecological variability to better predict emergence patterns.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v15020310