Optogenetic control of phosphoinositide metabolism

Phosphoinositides (PIs) are lipid components of cell membranes that regulate a wide variety of cellular functions. Here we exploited the blue light-induced dimerization between two plant proteins, cryptochrome 2 (CRY2) and the transcription factor CIBN, to control plasma membrane PI levels rapidly,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 109; H. 35; S. E2316
Hauptverfasser:	Idevall-Hagren, Olof, Dickson, Eamonn J, Hille, Bertil, Toomre, Derek K, De Camilli, Pietro
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 28.08.2012
Schlagworte:	Actins - metabolism Amino Acid Motifs - physiology Animals Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Binding Sites - physiology Cell Membrane - metabolism Cell Membrane - radiation effects Cercopithecus aethiops COS Cells Cryptochromes - genetics Cryptochromes - metabolism Endocytosis - physiology Endocytosis - radiation effects Humans KCNQ2 Potassium Channel - physiology KCNQ3 Potassium Channel - physiology Light Membrane Potentials - physiology Membrane Potentials - radiation effects PC12 Cells Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol 4,5-Diphosphate - metabolism Phosphatidylinositols - metabolism Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Phosphorylation - physiology Phosphorylation - radiation effects Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal Transduction - physiology Signal Transduction - radiation effects
ISSN:	1091-6490, 1091-6490
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