Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis

Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been the primary interest among studies on antiviral discovery, viral replication kinetics, drug resistance, and viral evolution. Following infection and entry into target cells, the HIV-1 core disassembles, and the viral RT...

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Bibliographic Details
Published in:	Viruses Vol. 14; no. 8; p. 1622
Main Authors:	Bowen, Nicole E., Oo, Adrian, Kim, Baek
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 26.07.2022 MDPI
Subjects:	Antiretroviral drugs antiretroviral therapy Antiviral Agents - pharmacology Antiviral drugs Binding sites Deoxyribonucleic acid DNA DNA polymerase DNA-directed DNA polymerase DNA-Directed DNA Polymerase - genetics Double-stranded RNA Drug resistance Enzyme kinetics evolution Exonuclease Genetic aspects genome Genomes Genomics HIV HIV (Viruses) HIV Reverse Transcriptase - genetics HIV Reverse Transcriptase - metabolism HIV-1 - genetics HIV-1 - metabolism Human immunodeficiency virus Human immunodeficiency virus 1 human immunodeficiency virus type 1 Humans Immune system Infections Life cycles Lymphocytes Methods Mutagenesis Mutation Myeloid cells Myeloid Cells - metabolism Proofreading Proteins Replication retrovirus reverse transcriptase Review RNA RNA-directed DNA polymerase SAM Domain and HD Domain-Containing Protein 1 - genetics SAM Domain and HD Domain-Containing Protein 1 - metabolism therapeutics Tropism Viral Tropism Virus Replication Viruses United States human immunodeficiency virus type 1 mutation retrovirus reverse transcriptase antiretroviral therapy drug resistance SAMHD1 cell tropism
ISSN:	1999-4915, 1999-4915
Online Access:	Get full text
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