Flavonoids: promising natural compounds against viral infections

Flavonoids are widely distributed as secondary metabolites produced by plants and play important roles in plant physiology, having a variety of potential biological benefits such as antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal and antiviral activity. Different flavonoids hav...

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Veröffentlicht in:Archives of virology Jg. 162; H. 9; S. 2539 - 2551
Hauptverfasser: Zakaryan, Hovakim, Arabyan, Erik, Oo, Adrian, Zandi, Keivan
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Vienna Springer Vienna 01.09.2017
Springer Nature B.V
Schlagworte:
Animals
antioxidants
Antiviral activity
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
antiviral properties
Biomedical and Life Sciences
Biomedicine
Flavonoids
Flavonoids - chemistry
Flavonoids - metabolism
Flavonoids - pharmacology
Humans
in vivo studies
Infectious Diseases
Inflammation
mechanism of action
Medical Microbiology
Metabolites
Molecular modelling
Molecular Structure
plant physiology
Plants - chemistry
Plants - metabolism
Review
Secondary metabolites
Therapeutic applications
Viral infections
Virology
Virus Diseases - drug therapy
viruses
ISSN:0304-8608, 1432-8798, 1432-8798
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Flavonoids are widely distributed as secondary metabolites produced by plants and play important roles in plant physiology, having a variety of potential biological benefits such as antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal and antiviral activity. Different flavonoids have been investigated for their potential antiviral activities and several of them exhibited significant antiviral properties in in vitro and even in vivo studies. This review summarizes the evidence for antiviral activity of different flavonoids, highlighting, where investigated, the cellular and molecular mechanisms of action on viruses. We also present future perspectives on therapeutic applications of flavonoids against viral infections.
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ISSN:0304-8608
1432-8798
1432-8798
DOI:10.1007/s00705-017-3417-y