Quality control initiative on the evaluation of the dysmegakaryopoiesis in myeloid neoplasms: Difficulties in the assessment of dysplasia

•The presence of micromegakaryocytes correlates strongly with myeloid neoplasia.•Micromegakaryocytes can be identified reliably.•Multinucleated megakaryocytes are not specific for myeloid neoplasia.•Cytoplasmic dysplasia is not useful in recognising MDS.•‘Possibly dysplastic’ cells should be exclude...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Leukemia research Ročník 45; s. 75 - 81
Hlavní autoři:	Goasguen, Jean E., Bennett, John M., Bain, Barbara J., Brunning, Richard D., Vallespí, Maria-Teresa, Tomonaga, Masao, Zini, Gina, Renault, Alain
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.06.2016 Elsevier
Témata:	Cancer Cell Shape Cell Size Dysmegakaryocytopoiesis Dysmegakaryopoiesis Dysmyelopoiesis Dysplastic features Hematologic Neoplasms - pathology Hematology Hematology, Oncology and Palliative Medicine Human health and pathology Humans Life Sciences Megakaryocyte Progenitor Cells Megakaryocytes Megakaryocytes - pathology Myelodysplastic syndrome Myelodysplastic Syndromes - diagnosis Myeloproliferative Disorders - diagnosis Quality Control Tissues and Organs Dysplastic features Megakaryocytes Dysmegakaryopoiesis Dysmegakaryocytopoiesis Myelodysplastic syndrome Dysmyelopoiesis myelodysplastic syndrome
ISSN:	0145-2126, 1873-5835, 1873-5835, 0145-2126
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	•The presence of micromegakaryocytes correlates strongly with myeloid neoplasia.•Micromegakaryocytes can be identified reliably.•Multinucleated megakaryocytes are not specific for myeloid neoplasia.•Cytoplasmic dysplasia is not useful in recognising MDS.•‘Possibly dysplastic’ cells should be excluded from counts in suspected MDS. Evaluation of megakaryocyte morphology is difficult but can be essential for the diagnosis of myelodysplastic syndromes (MDS) and other myeloid neoplasms. We agreed upon descriptions and provided images of megakaryoblasts and of normal and dysplastic megakaryocytes, which were used as a basis for assessing the concordance of expert morphologists in their recognition. We showed a high rate of concordance for the recognition of micromegakaryocytes and confirmed their strong association with hematologic neoplasia, including MDS. Concordance was also found to be good for the recognition of multinucleated megakaryocytes, which showed a significant association with MDS. However cytoplasmic abnormalities were found not to be useful in MDS recognition. The occurrence of appreciable numbers of nonlobulated and hypolobulated megakaryocytes in individuals without a myeloid neoplasm was confirmed. We demonstrated that subjects without a myeloid neoplasm can have some megakaryocytes that are assessed as ‘dysplastic’ or ‘possibly dysplastic’ and that to avoid over diagnosis of dysplasia, ‘possibly dysplastic’ forms should be excluded from the count of dysplastic cells. Our results demonstrate that the nature as well as the presence of megakaryocyte dysplasia is important in the diagnosis of MDS; although evaluation of 30 megakaryocytes is strongly recommended, it may be possible to recognize diagnostically important dysplasia when fewer megakaryocytes are present but highly diagnostic forms are seen.
AbstractList	•The presence of micromegakaryocytes correlates strongly with myeloid neoplasia.•Micromegakaryocytes can be identified reliably.•Multinucleated megakaryocytes are not specific for myeloid neoplasia.•Cytoplasmic dysplasia is not useful in recognising MDS.•‘Possibly dysplastic’ cells should be excluded from counts in suspected MDS. Evaluation of megakaryocyte morphology is difficult but can be essential for the diagnosis of myelodysplastic syndromes (MDS) and other myeloid neoplasms. We agreed upon descriptions and provided images of megakaryoblasts and of normal and dysplastic megakaryocytes, which were used as a basis for assessing the concordance of expert morphologists in their recognition. We showed a high rate of concordance for the recognition of micromegakaryocytes and confirmed their strong association with hematologic neoplasia, including MDS. Concordance was also found to be good for the recognition of multinucleated megakaryocytes, which showed a significant association with MDS. However cytoplasmic abnormalities were found not to be useful in MDS recognition. The occurrence of appreciable numbers of nonlobulated and hypolobulated megakaryocytes in individuals without a myeloid neoplasm was confirmed. We demonstrated that subjects without a myeloid neoplasm can have some megakaryocytes that are assessed as ‘dysplastic’ or ‘possibly dysplastic’ and that to avoid over diagnosis of dysplasia, ‘possibly dysplastic’ forms should be excluded from the count of dysplastic cells. Our results demonstrate that the nature as well as the presence of megakaryocyte dysplasia is important in the diagnosis of MDS; although evaluation of 30 megakaryocytes is strongly recommended, it may be possible to recognize diagnostically important dysplasia when fewer megakaryocytes are present but highly diagnostic forms are seen. Evaluation of megakaryocyte morphology is difficult but can be essential for the diagnosis of myelodysplastic syndromes (MDS) and other myeloid neoplasms. We agreed upon descriptions and provided images of megakaryoblasts and of normal and dysplastic megakaryocytes, which were used as a basis for assessing the concordance of expert morphologists in their recognition. We showed a high rate of concordance for the recognition of micromegakaryocytes and confirmed their strong association with hematologic neoplasia, including MDS. Concordance was also found to be good for the recognition of multinucleated megakaryocytes, which showed a significant association with MDS. However cytoplasmic abnormalities were found not to be useful in MDS recognition. The occurrence of appreciable numbers of nonlobulated and hypolobulated megakaryocytes in individuals without a myeloid neoplasm was confirmed. We demonstrated that subjects without a myeloid neoplasm can have some megakaryocytes that are assessed as 'dysplastic' or 'possibly dysplastic' and that to avoid over diagnosis of dysplasia, 'possibly dysplastic' forms should be excluded from the count of dysplastic cells. Our results demonstrate that the nature as well as the presence of megakaryocyte dysplasia is important in the diagnosis of MDS; although evaluation of 30 megakaryocytes is strongly recommended, it may be possible to recognize diagnostically important dysplasia when fewer megakaryocytes are present but highly diagnostic forms are seen. Highlights • The presence of micromegakaryocytes correlates strongly with myeloid neoplasia. • Micromegakaryocytes can be identified reliably. • Multinucleated megakaryocytes are not specific for myeloid neoplasia. • Cytoplasmic dysplasia is not useful in recognising MDS. • ‘Possibly dysplastic’ cells should be excluded from counts in suspected MDS. Evaluation of megakaryocyte morphology is difficult but can be essential for the diagnosis of myelodysplastic syndromes (MDS) and other myeloid neoplasms. We agreed upon descriptions and provided images of megakaryoblasts and of normal and dysplastic megakaryocytes, which were used as a basis for assessing the concordance of expert morphologists in their recognition. We showed a high rate of concordance for the recognition of micromegakaryocytes and confirmed their strong association with hematologic neoplasia, including MDS. Concordance was also found to be good for the recognition of multinucleated megakaryocytes, which showed a significant association with MDS. However cytoplasmic abnormalities were found not to be useful in MDS recognition. The occurrence of appreciable numbers of nonlobulated and hypolobulated megakaryocytes in individuals without a myeloid neoplasm was confirmed. We demonstrated that subjects without a myeloid neoplasm can have some megakaryocytes that are assessed as 'dysplastic' or 'possibly dysplastic' and that to avoid over diagnosis of dysplasia, 'possibly dysplastic' forms should be excluded from the count of dysplastic cells. Our results demonstrate that the nature as well as the presence of megakaryocyte dysplasia is important in the diagnosis of MDS; although evaluation of 30 megakaryocytes is strongly recommended, it may be possible to recognize diagnostically important dysplasia when fewer megakaryocytes are present but highly diagnostic forms are seen.Evaluation of megakaryocyte morphology is difficult but can be essential for the diagnosis of myelodysplastic syndromes (MDS) and other myeloid neoplasms. We agreed upon descriptions and provided images of megakaryoblasts and of normal and dysplastic megakaryocytes, which were used as a basis for assessing the concordance of expert morphologists in their recognition. We showed a high rate of concordance for the recognition of micromegakaryocytes and confirmed their strong association with hematologic neoplasia, including MDS. Concordance was also found to be good for the recognition of multinucleated megakaryocytes, which showed a significant association with MDS. However cytoplasmic abnormalities were found not to be useful in MDS recognition. The occurrence of appreciable numbers of nonlobulated and hypolobulated megakaryocytes in individuals without a myeloid neoplasm was confirmed. We demonstrated that subjects without a myeloid neoplasm can have some megakaryocytes that are assessed as 'dysplastic' or 'possibly dysplastic' and that to avoid over diagnosis of dysplasia, 'possibly dysplastic' forms should be excluded from the count of dysplastic cells. Our results demonstrate that the nature as well as the presence of megakaryocyte dysplasia is important in the diagnosis of MDS; although evaluation of 30 megakaryocytes is strongly recommended, it may be possible to recognize diagnostically important dysplasia when fewer megakaryocytes are present but highly diagnostic forms are seen.
Author	Brunning, Richard D. Renault, Alain Goasguen, Jean E. Vallespí, Maria-Teresa Tomonaga, Masao Bain, Barbara J. Bennett, John M. Zini, Gina
Author_xml	– sequence: 1 givenname: Jean E. surname: Goasguen fullname: Goasguen, Jean E. email: Jean.goasguen@orange.fr organization: University of Rennes, France – sequence: 2 givenname: John M. surname: Bennett fullname: Bennett, John M. organization: University of Rochester, NY, USA – sequence: 3 givenname: Barbara J. surname: Bain fullname: Bain, Barbara J. organization: Imperial College, London, UK – sequence: 4 givenname: Richard D. surname: Brunning fullname: Brunning, Richard D. organization: University of Minnesota, USA – sequence: 5 givenname: Maria-Teresa surname: Vallespí fullname: Vallespí, Maria-Teresa organization: Vall d’Hebrón Hospital, Barcelona, Spain – sequence: 6 givenname: Masao surname: Tomonaga fullname: Tomonaga, Masao organization: University of Nagasaki, Japan – sequence: 7 givenname: Gina surname: Zini fullname: Zini, Gina organization: Haematology Institute, Catholic University of Sacred Heart, Rome, Italy – sequence: 8 givenname: Alain surname: Renault fullname: Renault, Alain organization: University of Rennes and INSERM CIC1414, France
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27107657$$D View this record in MEDLINE/PubMed https://univ-rennes.hal.science/hal-01301508$$DView record in HAL
BookMark	eNqNktFu0zAUhi00xLrBI4ByCRctx0mc2CBA0wYMqRJCwLXlOCfMrRMX26nUR-Ct56wdF5NQubJ89P2_z_H5z8jJ4AYk5DmFBQVavV4tLI5rj2GRp-sCygWAeERmlNfFnPGCnZAZ0JLNc5pXp-QshBUAMEHFE3Ka1xTqitUz8ufbqKyJu0y7IXpnMzOYaFQ0W8zckMUbzHCr7Jgq6eq6u0q7Cz3-Umvld27jDAYTki7rd2idabMB3caq0Ic32ZXpOqNHGxM0IZNahYAhGQxx8kteE2zUU_K4Uzbgs8N5Tn5--vjj8nq-_Pr5y-XFcq5ZJcS8KZu6gxoV7xSvtKg1CgUlY6IpVdm2TRqMiqopUCNtO8gr2hUt8po1IlelLs7Jq73vjbJy402fppBOGXl9sZRTDWgBlAHf0sS-3LMb736PGKLsTdBorUozjkFSDrwSDKA-jtZcQFFwXiX0xQEdmx7bv03cbyUBb_eA9i4Ej53UJt5tIHplrKQgpwzIlTxkQE4ZkFDKlIGkZg_U9w8c033Y6zD9_tagl0EbHDS2xqOOsnXmqMP7Bw7apjxpZde4w7Byox_SaiWVIZcgv0_5nOJJqwKgFHkyePdvg_9o4BYGiPrC
CitedBy_id	crossref_primary_10_1053_j_semdp_2023_04_008 crossref_primary_10_1080_10428194_2021_2018581 crossref_primary_10_1111_bjh_16615 crossref_primary_10_1016_j_prp_2025_155930 crossref_primary_10_1093_ajcp_aqac094 crossref_primary_10_1111_bjh_16891 crossref_primary_10_3390_diagnostics14232720 crossref_primary_10_1111_bjh_17026 crossref_primary_10_1002_ajh_26963 crossref_primary_10_1111_ijlh_13536 crossref_primary_10_1016_j_bulcan_2023_02_030 crossref_primary_10_3390_cells14080588 crossref_primary_10_1097_PAI_0000000000001177 crossref_primary_10_1111_ijlh_13908 crossref_primary_10_1111_ijlh_12819 crossref_primary_10_3390_diagnostics14151631 crossref_primary_10_1002_gcc_23107 crossref_primary_10_1038_s41375_019_0704_5 crossref_primary_10_1016_j_leukres_2017_02_008 crossref_primary_10_1177_1093526618822108 crossref_primary_10_1111_bjh_15435 crossref_primary_10_1016_j_clml_2016_08_005 crossref_primary_10_1016_j_leukres_2017_10_004 crossref_primary_10_1038_s41598_022_21887_w crossref_primary_10_1002_ajh_24554 crossref_primary_10_1016_j_leukres_2018_06_003 crossref_primary_10_1007_s11899_017_0405_y crossref_primary_10_1097_PAS_0000000000001732 crossref_primary_10_1038_s41375_021_01435_7 crossref_primary_10_1515_cclm_2018_0161
Cites_doi	10.1111/j.1365-2141.1986.tb07550.x 10.1046/j.1365-2141.2000.01940.x 10.1038/leu.2014.161 10.1182/blood.V43.6.811.811 10.7326/0003-4819-103-3-460 10.1046/j.1365-2141.1996.d01-1786.x 10.1084/jem.36.1.1 10.1182/asheducation-2015.1.294 10.1159/000206652 10.1111/j.1365-2141.1982.tb08475.x 10.1080/1042819021000040279 10.1038/sj.leu.2404571 10.3816/CLK.2008.n.012
ContentType	Journal Article
Copyright	2016 Copyright © 2016. Published by Elsevier Ltd. Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml	– notice: 2016 – notice: Copyright © 2016. Published by Elsevier Ltd. – notice: Distributed under a Creative Commons Attribution 4.0 International License
CorporateAuthor	The International Working Group on Morphology of MDS IWGM-MDS International Working Group on Morphology of MDS IWGM-MDS
CorporateAuthor_xml	– name: The International Working Group on Morphology of MDS IWGM-MDS – name: International Working Group on Morphology of MDS IWGM-MDS
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7T5 H94 1XC VOOES
DOI	10.1016/j.leukres.2016.04.009
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Immunology Abstracts AIDS and Cancer Research Abstracts Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AIDS and Cancer Research Abstracts Immunology Abstracts
DatabaseTitleList	AIDS and Cancer Research Abstracts MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1873-5835 0145-2126
EndPage	81
ExternalDocumentID	oai:HAL:hal-01301508v1 27107657 10_1016_j_leukres_2016_04_009 S0145212616300492 1_s2_0_S0145212616300492
Genre	Journal Article
GroupedDBID	--- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29L 4.4 457 4CK 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABEFU ABFNM ABGSF ABJNI ABMAC ABMZM ABUDA ABWVN ABXDB ACDAQ ACGFS ACIEU ACIUM ACLOT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADUVX AEBSH AEHWI AEIPS AEKER AENEX AEUPX AEVXI AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGHFR AGQPQ AGRDE AGUBO AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HED HMK HMO HVGLF HZ~ IHE J1W J5H K-O KOM L7B M29 M41 MO0 N9A O-L O9- OAUVE OC~ OO- OZT P-8 P-9 PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SEL SES SEW SPCBC SSH SSU SSZ T5K WUQ Z5R ZGI ~G- ~HD AACTN AFCTW AFKWA AJOXV AMFUW RIG AAIAV ABLVK ABYKQ AJBFU DOVZS LCYCR 9DU AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7T5 H94 1XC VOOES
ID	FETCH-LOGICAL-c5699-b4b7f07ea8fa86c97ce9a04559b4a4ddb076196b3ece1df0261f3de875b92a4c3
ISSN	0145-2126 1873-5835
IngestDate	Sat Nov 29 15:05:42 EST 2025 Thu Oct 02 11:13:25 EDT 2025 Sun Nov 09 11:00:12 EST 2025 Thu Apr 03 06:58:58 EDT 2025 Sat Nov 29 01:42:13 EST 2025 Tue Nov 18 22:20:17 EST 2025 Fri Feb 23 02:30:52 EST 2024 Tue Feb 25 19:59:29 EST 2025 Tue Oct 14 19:41:49 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	Dysplastic features Megakaryocytes Dysmegakaryopoiesis Dysmegakaryocytopoiesis Myelodysplastic syndrome Dysmyelopoiesis myelodysplastic syndrome
Language	English
License	Copyright © 2016. Published by Elsevier Ltd. Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c5699-b4b7f07ea8fa86c97ce9a04559b4a4ddb076196b3ece1df0261f3de875b92a4c3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://univ-rennes.hal.science/hal-01301508
PMID	27107657
PQID	1789033886
PQPubID	23479
PageCount	7
ParticipantIDs	hal_primary_oai_HAL_hal_01301508v1 proquest_miscellaneous_1808695007 proquest_miscellaneous_1789033886 pubmed_primary_27107657 crossref_citationtrail_10_1016_j_leukres_2016_04_009 crossref_primary_10_1016_j_leukres_2016_04_009 elsevier_sciencedirect_doi_10_1016_j_leukres_2016_04_009 elsevier_clinicalkeyesjournals_1_s2_0_S0145212616300492 elsevier_clinicalkey_doi_10_1016_j_leukres_2016_04_009
PublicationCentury	2000
PublicationDate	2016-06-01
PublicationDateYYYYMMDD	2016-06-01
PublicationDate_xml	– month: 06 year: 2016 text: 2016-06-01 day: 01
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	Leukemia research
PublicationTitleAlternate	Leuk Res
PublicationYear	2016
Publisher	Elsevier Ltd Elsevier
Publisher_xml	– name: Elsevier Ltd – name: Elsevier
References	Brunning, Orazi, Germing, le Beau, Porwit, Bauman (bib0020) 2008 Minot (bib0005) 1922; 36 Arber, Hasserjian (bib0030) 2015; 2015 Bennett, Catovsky, Daniel, Flandrin, Galton, Gralnick (bib0010) 1982; 51 Maldonado (bib0045) 1974; 43 Matsuda, Jinnai, Miyazaki (bib0065) 2008; 2 Litz, Davies, Brunning, Kurk, Parkin, Gajl Peczalska (bib0055) 1995; 9 Bennett, Catovsky, Daniel, Flandrin, Galton, Gralnick (bib0015) 1985; 103 Arber, Brunning, Orazi, Bain, Porwit, Vardiman (bib0025) 2008 Bain (bib0040) 1996; 94 Matsuda, Germing, Jinnai, Iwanaga, Misumi, Kuendgen (bib0075) 2007; 21 Franzén, Strenger, Zajicek (bib0060) 1961; 26 Della Porta, Travaglino, Boveri, Ponzoni, Malcovati, Papaemmanuil (bib0080) 2015; 29 Kuriyama, Tomonaga, Matsuo, Ginnai, Ichimaru (bib0035) 1986; 63 Duchayne, Fenneteau, Pages, Sainty, Arnoulet, Dastugue (bib0050) 2003; 44 Germing, Gattermann, Aivido, Hildebrandt, Aul (bib0070) 2000; 108 Bennett (10.1016/j.leukres.2016.04.009_bib0015) 1985; 103 Matsuda (10.1016/j.leukres.2016.04.009_bib0065) 2008; 2 Germing (10.1016/j.leukres.2016.04.009_bib0070) 2000; 108 Litz (10.1016/j.leukres.2016.04.009_bib0055) 1995; 9 Matsuda (10.1016/j.leukres.2016.04.009_bib0075) 2007; 21 Kuriyama (10.1016/j.leukres.2016.04.009_bib0035) 1986; 63 Duchayne (10.1016/j.leukres.2016.04.009_bib0050) 2003; 44 Arber (10.1016/j.leukres.2016.04.009_bib0030) 2015; 2015 Franzén (10.1016/j.leukres.2016.04.009_bib0060) 1961; 26 Maldonado (10.1016/j.leukres.2016.04.009_bib0045) 1974; 43 Bennett (10.1016/j.leukres.2016.04.009_bib0010) 1982; 51 Minot (10.1016/j.leukres.2016.04.009_bib0005) 1922; 36 Arber (10.1016/j.leukres.2016.04.009_bib0025) 2008 Brunning (10.1016/j.leukres.2016.04.009_bib0020) 2008 Bain (10.1016/j.leukres.2016.04.009_bib0040) 1996; 94 Della Porta (10.1016/j.leukres.2016.04.009_bib0080) 2015; 29
References_xml	– volume: 29 start-page: 66 year: 2015 end-page: 75 ident: bib0080 article-title: on behalf of Rete Ematologica Lombarda (REL) clinical network in 2014. Myelodysplasias: minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes publication-title: Leukemia – volume: 44 start-page: 49 year: 2003 end-page: 58 ident: bib0050 article-title: Acute megakaryoblastic leukaemia: a national clinical and biological study of 53 adult and childhood cases by the Groupe Francais d’Hematologie Cellulaire (GFHC) publication-title: Leuk. Lymphoma – volume: 51 start-page: 189 year: 1982 end-page: 199 ident: bib0010 article-title: Proposals for the classification of the myelodysplastic syndromes publication-title: Br. J. Haematol. – volume: 2 start-page: 102 year: 2008 end-page: 106 ident: bib0065 article-title: Tomonaga: proposals for a grading system for diagnostic accuracy of myelodysplastic syndromes publication-title: Clin. Leuk. – volume: 21 start-page: 678 year: 2007 end-page: 686 ident: bib0075 article-title: Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological features in patients with refractory anemia according to the FAB classification publication-title: Leukemia – volume: 94 start-page: 206 year: 1996 end-page: 209 ident: bib0040 article-title: The bone marrow aspirate of healthy subjects publication-title: Br. J. Haematol. – volume: 26 start-page: 182 year: 1961 end-page: 193 ident: bib0060 article-title: Microplanimetric studies on megakaryocytes in chronic granulocytic leukaemia and polycythaemia vera publication-title: Acta Haematol. – volume: 36 start-page: 1 year: 1922 ident: bib0005 article-title: Megakaryocytes in the peripheral circulation publication-title: J. Exp. Med. – start-page: 88 year: 2008 end-page: 93 ident: bib0020 article-title: Myelodysplastic syndromes/neoplasms, overview publication-title: World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues – volume: 9 start-page: 1432 year: 1995 end-page: 1439 ident: bib0055 article-title: Acute leukemia and transient myeloproliferative disorder associated with Down syndrome: morphologic immunophenotypic and cytogenetic manifestations publication-title: Leukemia – volume: 103 start-page: 460 year: 1985 end-page: 462 ident: bib0015 article-title: Criteria for the diagnosis of acute leukemia of megakaryocytic lineage (M7): a report of the French–American–British Cooperative Group publication-title: Ann. Intern. Med. – start-page: 124 year: 2008 end-page: 126 ident: bib0025 article-title: Acute myeloid leukaemia with myelodysplasia-related changes publication-title: World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues – volume: 2015 start-page: 294 year: 2015 end-page: 298 ident: bib0030 article-title: Reclassifying myelodysplastic syndromes: what’s where in the new WHO and why publication-title: Hematology – volume: 63 start-page: 665 year: 1986 end-page: 669 ident: bib0035 article-title: Diagnostic significance of detecting pseudo-Pelger–Huët anomalies and micromegakaryocytes in myelodysplastic syndrome publication-title: Br. J. Haematol. – volume: 108 start-page: 724 year: 2000 end-page: 728 ident: bib0070 article-title: Two types of acquired sideroblastic anaemia (AISA): a time-tested distinction publication-title: Br. J. Haematol. – volume: 43 start-page: 811 year: 1974 end-page: 820 ident: bib0045 article-title: Dysplastic platelets and circulating megakaryocytes in chronic myeloproliferative diseases. II ultrastructure of circulating megakaryocytes publication-title: Blood – volume: 63 start-page: 665 year: 1986 ident: 10.1016/j.leukres.2016.04.009_bib0035 article-title: Diagnostic significance of detecting pseudo-Pelger–Huët anomalies and micromegakaryocytes in myelodysplastic syndrome publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.1986.tb07550.x – volume: 108 start-page: 724 year: 2000 ident: 10.1016/j.leukres.2016.04.009_bib0070 article-title: Two types of acquired sideroblastic anaemia (AISA): a time-tested distinction publication-title: Br. J. Haematol. doi: 10.1046/j.1365-2141.2000.01940.x – volume: 29 start-page: 66 year: 2015 ident: 10.1016/j.leukres.2016.04.009_bib0080 article-title: on behalf of Rete Ematologica Lombarda (REL) clinical network in 2014. Myelodysplasias: minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes publication-title: Leukemia doi: 10.1038/leu.2014.161 – volume: 43 start-page: 811 year: 1974 ident: 10.1016/j.leukres.2016.04.009_bib0045 article-title: Dysplastic platelets and circulating megakaryocytes in chronic myeloproliferative diseases. II ultrastructure of circulating megakaryocytes publication-title: Blood doi: 10.1182/blood.V43.6.811.811 – volume: 103 start-page: 460 year: 1985 ident: 10.1016/j.leukres.2016.04.009_bib0015 article-title: Criteria for the diagnosis of acute leukemia of megakaryocytic lineage (M7): a report of the French–American–British Cooperative Group publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-103-3-460 – volume: 94 start-page: 206 year: 1996 ident: 10.1016/j.leukres.2016.04.009_bib0040 article-title: The bone marrow aspirate of healthy subjects publication-title: Br. J. Haematol. doi: 10.1046/j.1365-2141.1996.d01-1786.x – volume: 9 start-page: 1432 year: 1995 ident: 10.1016/j.leukres.2016.04.009_bib0055 article-title: Acute leukemia and transient myeloproliferative disorder associated with Down syndrome: morphologic immunophenotypic and cytogenetic manifestations publication-title: Leukemia – volume: 36 start-page: 1 year: 1922 ident: 10.1016/j.leukres.2016.04.009_bib0005 article-title: Megakaryocytes in the peripheral circulation publication-title: J. Exp. Med. doi: 10.1084/jem.36.1.1 – start-page: 88 year: 2008 ident: 10.1016/j.leukres.2016.04.009_bib0020 article-title: Myelodysplastic syndromes/neoplasms, overview – volume: 2015 start-page: 294 year: 2015 ident: 10.1016/j.leukres.2016.04.009_bib0030 article-title: Reclassifying myelodysplastic syndromes: what’s where in the new WHO and why publication-title: Hematology doi: 10.1182/asheducation-2015.1.294 – volume: 26 start-page: 182 year: 1961 ident: 10.1016/j.leukres.2016.04.009_bib0060 article-title: Microplanimetric studies on megakaryocytes in chronic granulocytic leukaemia and polycythaemia vera publication-title: Acta Haematol. doi: 10.1159/000206652 – volume: 51 start-page: 189 year: 1982 ident: 10.1016/j.leukres.2016.04.009_bib0010 article-title: Proposals for the classification of the myelodysplastic syndromes publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.1982.tb08475.x – volume: 44 start-page: 49 year: 2003 ident: 10.1016/j.leukres.2016.04.009_bib0050 article-title: Acute megakaryoblastic leukaemia: a national clinical and biological study of 53 adult and childhood cases by the Groupe Francais d’Hematologie Cellulaire (GFHC) publication-title: Leuk. Lymphoma doi: 10.1080/1042819021000040279 – start-page: 124 year: 2008 ident: 10.1016/j.leukres.2016.04.009_bib0025 article-title: Acute myeloid leukaemia with myelodysplasia-related changes – volume: 21 start-page: 678 year: 2007 ident: 10.1016/j.leukres.2016.04.009_bib0075 article-title: Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological features in patients with refractory anemia according to the FAB classification publication-title: Leukemia doi: 10.1038/sj.leu.2404571 – volume: 2 start-page: 102 year: 2008 ident: 10.1016/j.leukres.2016.04.009_bib0065 article-title: Tomonaga: proposals for a grading system for diagnostic accuracy of myelodysplastic syndromes publication-title: Clin. Leuk. doi: 10.3816/CLK.2008.n.012
SSID	ssj0005919
Score	2.3051488
Snippet	•The presence of micromegakaryocytes correlates strongly with myeloid neoplasia.•Micromegakaryocytes can be identified reliably.•Multinucleated megakaryocytes... Highlights • The presence of micromegakaryocytes correlates strongly with myeloid neoplasia. • Micromegakaryocytes can be identified reliably. • Multinucleated... Evaluation of megakaryocyte morphology is difficult but can be essential for the diagnosis of myelodysplastic syndromes (MDS) and other myeloid neoplasms. We...
SourceID	hal proquest pubmed crossref elsevier
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	75
SubjectTerms	Cancer Cell Shape Cell Size Dysmegakaryocytopoiesis Dysmegakaryopoiesis Dysmyelopoiesis Dysplastic features Hematologic Neoplasms - pathology Hematology Hematology, Oncology and Palliative Medicine Human health and pathology Humans Life Sciences Megakaryocyte Progenitor Cells Megakaryocytes Megakaryocytes - pathology Myelodysplastic syndrome Myelodysplastic Syndromes - diagnosis Myeloproliferative Disorders - diagnosis Quality Control Tissues and Organs
Title	Quality control initiative on the evaluation of the dysmegakaryopoiesis in myeloid neoplasms: Difficulties in the assessment of dysplasia
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0145212616300492 https://www.clinicalkey.es/playcontent/1-s2.0-S0145212616300492 https://dx.doi.org/10.1016/j.leukres.2016.04.009 https://www.ncbi.nlm.nih.gov/pubmed/27107657 https://www.proquest.com/docview/1789033886 https://www.proquest.com/docview/1808695007 https://univ-rennes.hal.science/hal-01301508
Volume	45
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-5835 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005919 issn: 0145-2126 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3bbtNAEF2lKUK8IK4lXCqDeKscfPcub6EECpSKhyLlbbW218VtYkdxEjWfwL_xUcys13YECS1IvESR5Vl7Myd7mT1zhpCXlqQ4y0amn0pqeolDYRz0wCG2Y6eSuVZqp6rYRHhyQkcj9qXT-VHnwizHYZ7Ty0s2_a-uhmvgbEyd_Qt3N43CBfgOTodPcDt8XsvxlSrGqiGhZ0gPquS9q4OBNYXvmiGQrMqJPBMXYrYqpgVsnjNFk52s5LjIkoMcaeainCj63FuM8qBgR6a4XMpeNPqe2CK0NlXZmesr32O5uJCTTBxoeaEmDP2-EOXZQueI4LlAq_2pcobmNWO4Ddy-EbrKfHVY0h5toY5Crqu0aMkATWnWgQ07aAlYTazTR8wE64O156-NtlXNlXretjfOCFVw4rw_hl5CB5HMFyhxW4u1U2B97D88_GSbpdO3TCS9YVpzYCtNsqpe3y_K3DYvHW7x327dIbtO6DPaJbuDD8PRx5ZyxFShmaZjbUbZq40vuG2ttPMNSbvbdkRqZXR6h9zWWxpjUEHxLunI_B65-VmTNu6T7xqRhkak0SLSKHID8GO0iDSKVF3ZgEiwMzQijQaRr411POItaN3iEdtr8PiAfH03PD08MnUFEDP2A8bMyIvC1AqloKmgQczCWDIBmxCfRZ7wkiRSUbggcmUs7STFeELqJhL24BFzhBe7D0k3L3L5iBiOH_si9aQdJI7n0kgklptKJ_SYT2Xghz3i1b81j7U8PlZpGfOaB3nOtYs4uohbHgcX9Ui_MZtW-jBXGQS1I3md_AzTNQe8XmUYbjKUpR57Sr4Njz1CG0u9rq7Wy9d56AvAWtMz1KI_GhxzvIaUBywmsbR75HkNRQ6TE544CoDBAt4I0-xdl9LgD_dQiwbMh71Kj-xVOG6e58D-JwTnPP7nvj8ht9qx5SnpzmcL-YzciJfzrJztk51wRPf13_QnsQkkXA
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quality+control+initiative+on+the+evaluation+of+the+dysmegakaryopoiesis+in+myeloid+neoplasms%3A+Difficulties+in+the+assessment+of+dysplasia&rft.jtitle=Leukemia+research&rft.au=Goasguen%2C+Jean+E&rft.au=Bennett%2C+John+M&rft.au=Bain%2C+Barbara+J&rft.au=Brunning%2C+Richard+D&rft.date=2016-06-01&rft.issn=0145-2126&rft.volume=45&rft.spage=75&rft.epage=81&rft_id=info:doi/10.1016%2Fj.leukres.2016.04.009&rft.externalDBID=ECK1-s2.0-S0145212616300492&rft.externalDocID=1_s2_0_S0145212616300492
thumbnail_m	http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01452126%2FS0145212616X00069%2Fcov150h.gif