Impact of allopurinol use on urate concentration and cardiovascular outcome

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Guidelines recommend that the therapeutic goal of urate‐lowering therapy (ULT) is to achieve a urate concentration of ≤6 mg dl−1. • High‐dose allopurinol is associated with reduced cardiovascular events and mortality in heart failure patients. WHAT THIS STU...

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Bibliographic Details
Published in:	British journal of clinical pharmacology Vol. 71; no. 4; pp. 600 - 607
Main Authors:	Wei, Li, Mackenzie, Isla S., Chen, Yang, Struthers, Allan D., MacDonald, Thomas M.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.04.2011 Blackwell Blackwell Science Inc
Subjects:	Aged Aged, 80 and over allopurinol Allopurinol - therapeutic use Biological and medical sciences Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality cardiovascular event Cohort Studies Female Gout - complications Gout - drug therapy Gout - mortality Gout Suppressants - therapeutic use Hospitalization - statistics & numerical data Humans Hyperuricemia - complications Hyperuricemia - drug therapy Hyperuricemia - mortality Male Medical sciences mortality Pharmacoepidemiology Pharmacology. Drug treatments Proportional Hazards Models Risk Factors Time Factors Treatment Outcome United Kingdom urate Uric Acid - analysis Hypouricemic agent Prognosis Enzyme Allopurinol Mortality cardiovascular event Enzyme inhibitor Cardiovascular disease Pyrazolopyrimidine derivatives urate Xanthine oxidase Oxidoreductases Circulatory system
ISSN:	0306-5251, 1365-2125, 1365-2125
Online Access:	Get full text
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