RNA covariation at helix-level resolution for the identification of evolutionarily conserved RNA structure

Many biologically important RNAs fold into specific 3D structures conserved through evolution. Knowing when an RNA sequence includes a conserved RNA structure that could lead to new biology is not trivial and depends on clues left behind by conservation in the form of covariation and variation. For...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 19; no. 7; p. e1011262
Main Author:	Rivas, Elena
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.07.2023
Subjects:	Alignment Base pairs Benchmarks Biology and life sciences Computer and Information Sciences Conserved sequence Datasets Evolution Gene sequencing Helices Hypotheses Methods Non-coding RNA Nucleotide sequence Phylogeny Physical Sciences Physiological aspects Power Protein structure Research and Analysis Methods Ribonucleic acid RNA Secondary structure Sensitivity Statistical analysis Statistical tests Structure United States
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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