Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica)

Pangolins are endangered animals in urgent need of protection. Identifying and cataloguing the viruses carried by pangolins is a logical approach to evaluate the range of potential pathogens and help with conservation. This study provides insight into viral communities of Malayan Pangolins (Manis ja...

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Vydáno v:Viruses Ročník 11; číslo 11; s. 979
Hlavní autoři: Liu, Ping, Chen, Wu, Chen, Jin-Ping
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 24.10.2019
MDPI
Témata:
Acids
animal diseases
coronavirus
Coronavirus infections
Coronaviruses
crossing over
DNA polymerase
Endangered species
Epidemiology
Genomes
hosts
Infections
mammals
Manis (Paramanis)
Manis javanica
Metagenomics
Microorganisms
molecular epidemiology
Murine respirovirus
Orthocoronavirinae
pathogens
Quality control
sendai virus
sequence homology
Spleen
virome
Viruses
United States > US
China
Germany
molecular epidemiology
virome
Coronavirus
Sendai virus
Manis javanica
ISSN:1999-4915, 1999-4915
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Shrnutí:Pangolins are endangered animals in urgent need of protection. Identifying and cataloguing the viruses carried by pangolins is a logical approach to evaluate the range of potential pathogens and help with conservation. This study provides insight into viral communities of Malayan Pangolins (Manis javanica) as well as the molecular epidemiology of dominant pathogenic viruses between Malayan Pangolin and other hosts. A total of 62,508 de novo assembled contigs were constructed, and a BLAST search revealed 3600 ones (≥300 nt) were related to viral sequences, of which 68 contigs had a high level of sequence similarity to known viruses, while dominant viruses were the Sendai virus and Coronavirus. This is the first report on the viral diversity of pangolins, expanding our understanding of the virome in endangered species, and providing insight into the overall diversity of viruses that may be capable of directly or indirectly crossing over into other mammals.
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ISSN:1999-4915
1999-4915
DOI:10.3390/v11110979