Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

The glomerulus is a highly specialized capillary tuft, which under pressure filters large amounts of water and small solutes into the urinary space, while retaining albumin and large proteins. The glomerular filtration barrier (GFB) is a highly specialized filtration interface between blood and urin...

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Veröffentlicht in:	Autophagy Jg. 11; H. 7; S. 1130 - 1145
Hauptverfasser:	Lenoir, Olivia, Jasiek, Magali, Hénique, Carole, Guyonnet, Léa, Hartleben, Björn, Bork, Tillmann, Chipont, Anna, Flosseau, Kathleen, Bensaada, Imane, Schmitt, Alain, Massé, Jean-Marc, Souyri, Michèle, Huber, Tobias B, Tharaux, Pierre-Louis
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Taylor & Francis 03.07.2015
Schlagworte:	Animals Apoptosis - drug effects autophagy Autophagy - drug effects Autophagy-Related Protein 5 Cells, Cultured Development Biology Diabetic Nephropathies - pathology Diabetic Nephropathies - physiopathology Diabetic Nephropathies - prevention & control diabetic nephropathy endothelial cells Endothelial Cells - drug effects Endothelial Cells - pathology Endothelial Cells - ultrastructure Gene Deletion Glomerular Filtration Rate - drug effects Glucose - pharmacology Integrases - metabolism Life Sciences Mesangial Cells - drug effects Mesangial Cells - pathology Mesangial Cells - ultrastructure Mice, Inbred C57BL Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - metabolism Phenotype podocytes Podocytes - drug effects Podocytes - pathology Podocytes - ultrastructure proteinuria sclerosis Translational Research Paper CASP3, caspase 3, apoptosis-related cysteine peptidase MTOR, mechanistic target of rapamycin endothelial cells autophagy DM, diabetes mellitus GEC, glomerular endothelial cells proteinuria STZ, streptozotocin TEM, transmission electron microscopy Nphs2, nephrosis 2, podocin sclerosis SQSTM1, sequestosome 1 Cdh5, cadherin 5 podocytes MAP1LC3A/B/LC3A/B), microtubule-associated protein 1 light chain 3 α/β GFB, glomerular filtration barrier GBM, glomerular basement membrane ESRD, end-stage renal disease α, WT1, Wilms tumor 1 TUBA, tubulin BUN, blood urea nitrogen DN, diabetic nephropathy diabetic nephropathy ESRD apoptosis-related cysteine peptidase GFB B sequestosome 1 LC3A DM diabetes mellitus DN mechanistic target of rapamycin blood urea nitrogen caspase 3 microtubule-associated protein 1 light chain 3 Cdh5 GBM MAP1LC3A CASP3 STZ Nphs2 BUN glomerular endothelial cells transmission electron microscopy nephrosis 2 glomerular filtration barrier GEC podocin TUBA tubulin cadherin 5 end-stage renal disease MTOR streptozotocin WT1 Wilms tumor 1 glomerular basement membrane SQSTM1 TEM
ISSN:	1554-8627, 1554-8635
Online-Zugang:	Volltext
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