Early-Life Environmental Exposures and Blood Pressure in Children

Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously. This study aims to evaluate the association between a wide range of...

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Vydané v:Journal of the American College of Cardiology Ročník 74; číslo 10; s. 1317
Hlavní autori: Warembourg, Charline, Maitre, Léa, Tamayo-Uria, Ibon, Fossati, Serena, Roumeliotaki, Theano, Aasvang, Gunn Marit, Andrusaityte, Sandra, Casas, Maribel, Cequier, Enrique, Chatzi, Lida, Dedele, Audrius, Gonzalez, Juan-Ramon, Gražulevičienė, Regina, Haug, Line Smastuen, Hernandez-Ferrer, Carles, Heude, Barbara, Karachaliou, Marianna, Krog, Norun Hjertager, McEachan, Rosemary, Nieuwenhuijsen, Mark, Petraviciene, Inga, Quentin, Joane, Robinson, Oliver, Sakhi, Amrit Kaur, Slama, Rémy, Thomsen, Cathrine, Urquiza, Jose, Vafeiadi, Marina, West, Jane, Wright, John, Vrijheid, Martine, Basagaña, Xavier
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 10.09.2019
Predmet:
Blood Pressure - drug effects
Blood Pressure Determination - methods
Blood Pressure Determination - statistics & numerical data
Built Environment
Child
Dichlorodiphenyl Dichloroethylene - analysis
Environmental Exposure - adverse effects
Environmental Exposure - classification
Environmental Exposure - prevention & control
Environmental Pollutants - adverse effects
Environmental Pollutants - analysis
Europe - epidemiology
Female
Holistic Health
Humans
Hypertension - diagnosis
Hypertension - epidemiology
Hypertension - prevention & control
Insecticides - adverse effects
Insecticides - analysis
Male
Meteorological Concepts
Polychlorinated Biphenyls - analysis
Pregnancy
Prenatal Exposure Delayed Effects - blood
Prenatal Exposure Delayed Effects - diagnosis
Prenatal Exposure Delayed Effects - epidemiology
Europe
blood pressure
epidemiology
environment
children
exposome
cohort
chemicals
ISSN:1558-3597, 1558-3597
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Shrnutí:Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously. This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood pressure (BP) in children. Systolic and diastolic BP were measured among 1,277 children from the European HELIX (Human Early-Life Exposome) cohort aged 6 to 11 years. Prenatal (n = 89) and postnatal (n = 128) exposures include air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals, and lifestyles. Two methods adjusted for confounders were applied: an exposome-wide association study considering the exposures independently, and the deletion-substitution-addition algorithm considering all the exposures simultaneously. Decreases in systolic BP were observed with facility density (β change for an interquartile-range increase in exposure: -1.7 mm Hg [95% confidence interval (CI): -2.5 to -0.8 mm Hg]), maternal concentrations of polychlorinated biphenyl 118 (-1.4 mm Hg [95% CI: -2.6 to -0.2 mm Hg]) and child concentrations of dichlorodiphenyldichloroethylene (DDE: -1.6 mm Hg [95% CI: -2.4 to -0.7 mm Hg]), hexachlorobenzene (-1.5 mm Hg [95% CI: -2.4 to -0.6 mm Hg]), and mono-benzyl phthalate (-0.7 mm Hg [95% CI: -1.3 to -0.1 mm Hg]), whereas increases in systolic BP were observed with outdoor temperature during pregnancy (1.6 mm Hg [95% CI: 0.2 to 2.9 mm Hg]), high fish intake during pregnancy (2.0 mm Hg [95% CI: 0.4 to 3.5 mm Hg]), maternal cotinine concentrations (1.2 mm Hg [95% CI: -0.3 to 2.8 mm Hg]), and child perfluorooctanoate concentrations (0.9 mm Hg [95% CI: 0.1 to 1.6 mm Hg]). Decreases in diastolic BP were observed with outdoor temperature at examination (-1.4 mm Hg [95% CI: -2.3 to -0.5 mm Hg]) and child DDE concentrations (-1.1 mm Hg [95% CI: -1.9 to -0.3 mm Hg]), whereas increases in diastolic BP were observed with maternal bisphenol-A concentrations (0.7 mm Hg [95% CI: 0.1 to 1.4 mm Hg]), high fish intake during pregnancy (1.2 mm Hg [95% CI: -0.2 to 2.7 mm Hg]), and child copper concentrations (0.9 mm Hg [95% CI: 0.3 to 1.6 mm Hg]). This study suggests that early-life exposure to several chemicals, as well as built environment and meteorological factors, may affect BP in children.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1558-3597
1558-3597
DOI:10.1016/j.jacc.2019.06.069