Advanced glycation end products are elevated in estrogen receptor-positive breast cancer patients, alter response to therapy, and can be targeted by lifestyle intervention

Purpose Lifestyle factors associated with personal behavior can alter tumor-associated biological pathways and thereby increase cancer risk, growth, and disease recurrence. Advanced glycation end products (AGEs) are reactive metabolites produced endogenously as a by-product of normal metabolism. A W...

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Bibliographic Details
Published in:	Breast cancer research and treatment Vol. 173; no. 3; pp. 559 - 571
Main Authors:	Walter, Katherine R., Ford, Marvella E., Gregoski, Mathew J., Kramer, Rita M., Knight, Kendrea D., Spruill, Laura, Nogueira, Lourdes M., Krisanits, Bradley A., Phan, Van, La Rue, Amanda C., Lilly, Michael B., Ambs, Stefan, Chan, King, Turner, Tonya F., Varner, Heidi, Singh, Shweta, Uribarri, Jaime, Garrett-Mayer, Elizabeth, Armeson, Kent E., Hilton, Ebony J., Clair, Mark J., Taylor, Marian H., Abbott, Andrea M., Findlay, Victoria J., Peterson, Lindsay L., Magwood, Gayenell, Turner, David P.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.02.2019 Springer Springer Nature B.V
Subjects:	Advanced glycosylation end products Age Aged Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - therapeutic use B cells Biomarkers Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer cells Cancer patients Cancer prevention Cancer research Cancer Survivors Care and treatment Cell Line, Tumor Combined Modality Therapy Drug Resistance, Neoplasm Estrogen receptors Estrogens Exercise Female Genetic aspects Genomes Glycation End Products, Advanced - blood Glycation End Products, Advanced - metabolism Glycosylation Health aspects Humans Life Style Lifestyles Medicine Medicine & Public Health Metabolites Middle Aged Mortality Neoplasm Grading Neoplasm Staging Oncology Patients Phenols (Class of compounds) Phenotypes Phosphorylation Physical activity Preclinical Study Receptors, Estrogen - metabolism Recurrence (Disease) Retirement benefits Risk Factors Signal Transduction - drug effects Tamoxifen Tamoxifen - administration & dosage Tamoxifen - therapeutic use Treatment Outcome Tumors Estrogen receptor Breast cancer Tamoxifen resistance Lifestyle intervention Advanced glycation end product
ISSN:	0167-6806, 1573-7217, 1573-7217
Online Access:	Get full text
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