Advanced glycation end products are elevated in estrogen receptor-positive breast cancer patients, alter response to therapy, and can be targeted by lifestyle intervention

Purpose Lifestyle factors associated with personal behavior can alter tumor-associated biological pathways and thereby increase cancer risk, growth, and disease recurrence. Advanced glycation end products (AGEs) are reactive metabolites produced endogenously as a by-product of normal metabolism. A W...

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Vydáno v:Breast cancer research and treatment Ročník 173; číslo 3; s. 559 - 571
Hlavní autoři: Walter, Katherine R., Ford, Marvella E., Gregoski, Mathew J., Kramer, Rita M., Knight, Kendrea D., Spruill, Laura, Nogueira, Lourdes M., Krisanits, Bradley A., Phan, Van, La Rue, Amanda C., Lilly, Michael B., Ambs, Stefan, Chan, King, Turner, Tonya F., Varner, Heidi, Singh, Shweta, Uribarri, Jaime, Garrett-Mayer, Elizabeth, Armeson, Kent E., Hilton, Ebony J., Clair, Mark J., Taylor, Marian H., Abbott, Andrea M., Findlay, Victoria J., Peterson, Lindsay L., Magwood, Gayenell, Turner, David P.
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Springer US 01.02.2019
Springer
Springer Nature B.V
Témata:
Advanced glycosylation end products
Age
Aged
Antineoplastic Agents, Hormonal - administration & dosage
Antineoplastic Agents, Hormonal - therapeutic use
B cells
Biomarkers
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer cells
Cancer patients
Cancer prevention
Cancer research
Cancer Survivors
Care and treatment
Cell Line, Tumor
Combined Modality Therapy
Drug Resistance, Neoplasm
Estrogen receptors
Estrogens
Exercise
Female
Genetic aspects
Genomes
Glycation End Products, Advanced - blood
Glycation End Products, Advanced - metabolism
Glycosylation
Health aspects
Humans
Life Style
Lifestyles
Medicine
Medicine & Public Health
Metabolites
Middle Aged
Mortality
Neoplasm Grading
Neoplasm Staging
Oncology
Patients
Phenols (Class of compounds)
Phenotypes
Phosphorylation
Physical activity
Preclinical Study
Receptors, Estrogen - metabolism
Recurrence (Disease)
Retirement benefits
Risk Factors
Signal Transduction - drug effects
Tamoxifen
Tamoxifen - administration & dosage
Tamoxifen - therapeutic use
Treatment Outcome
Tumors
Estrogen receptor
Breast cancer
Tamoxifen resistance
Lifestyle intervention
Advanced glycation end product
ISSN:0167-6806, 1573-7217, 1573-7217
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Shrnutí:Purpose Lifestyle factors associated with personal behavior can alter tumor-associated biological pathways and thereby increase cancer risk, growth, and disease recurrence. Advanced glycation end products (AGEs) are reactive metabolites produced endogenously as a by-product of normal metabolism. A Western lifestyle also promotes AGE accumulation in the body which is associated with disease phenotypes through modification of the genome, protein crosslinking/dysfunction, and aberrant cell signaling. Given the links between lifestyle, AGEs, and disease, we examined the association between dietary-AGEs and breast cancer. Methods We evaluated AGE levels in bio-specimens from estrogen receptor-positive (ER+) and estrogen receptor-negative (ER−) breast cancer patients, examined their role in therapy resistance, and assessed the ability of lifestyle intervention to reduce circulating AGE levels in ER+ breast cancer survivors. Results An association between ER status and AGE levels was observed in tumor and serum samples. AGE treatment of ER+ breast cancer cells altered ERα phosphorylation and promoted resistance to tamoxifen therapy. In a proof of concept study, physical activity and dietary intervention was shown to be viable options for reducing circulating AGE levels in breast cancer survivors. Conclusions There is a potential prognostic and therapeutic role for lifestyle derived AGEs in breast cancer. Given the potential benefits of lifestyle intervention on incidence and mortality, opportunities exist for the development of community health and nutritional programs aimed at reducing AGE exposure in order to improve breast cancer prevention and treatment outcomes.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0167-6806
1573-7217
1573-7217
DOI:10.1007/s10549-018-4992-7