Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study

Introduction Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. Protease-activated receptor-1 (PAR-1) is expressed by multiple cell types present in the lungs and can be activated by various proteases generated during acute inflammation. The cellular effe...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 16; no. 6; p. R238
Main Authors:	Schouten, Marcel, van't Veer, Cornelis, Roelofs, Joris JTH, Levi, Marcel, van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	London BioMed Central 27.12.2012 BioMed Central Ltd
Subjects:	Animals Blood Chemokines - blood Critical Care Medicine Cytokines - blood Emergency Medicine Histochemistry Immunity - physiology Infection Inflammation Inflammation - physiopathology Intensive Leukocytes (neutrophilic) Liver Lung Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Knockout Neutrophil Infiltration - physiology Pathogens Pneumonia Pneumonia, Pneumococcal Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - mortality Pneumonia, Pneumococcal - physiopathology Proteases Proteinase Proteinase-activated receptor 1 Receptor, PAR-1 - physiology Spleen Streptococcus pneumoniae Lower Bacterial Load Barrier Protective Effect Antibacterial Defense Proinflammatory Signaling Pathway Pneumococcal Pneumonia
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X
Online Access:	Get full text
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