A genome-wide association study of metabolic traits in human urine

Karsten Suhre and colleagues report a genome-wide association study of metabolic traits in human urine, using NMR spectrometry to measure 59 metabolites in urine from participants. They identify five loci influencing urine metabolite levels and point to a missense variant in AGXT2 as the likely caus...

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Veröffentlicht in:	Nature genetics Jg. 43; H. 6; S. 565 - 569
Hauptverfasser:	Suhre, Karsten, Wallaschofski, Henri, Raffler, Johannes, Friedrich, Nele, Haring, Robin, Michael, Kathrin, Wasner, Christina, Krebs, Alexander, Kronenberg, Florian, Chang, David, Meisinger, Christa, Wichmann, H-Erich, Hoffmann, Wolfgang, Völzke, Henry, Völker, Uwe, Teumer, Alexander, Biffar, Reiner, Kocher, Thomas, Felix, Stephan B, Illig, Thomas, Kroemer, Heyo K, Gieger, Christian, Römisch-Margl, Werner, Nauck, Matthias
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.06.2011 Nature Publishing Group
Schlagworte:	631/208/205/2138 631/208/2489/144 631/443/319 Agriculture Amino Acid Transport Systems, Basic - genetics Aminoisobutyric Acids - urine Animal Genetics and Genomics Arylamine N-Acetyltransferase - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Chronic kidney failure Detoxification Disease Enzymes Fundamental and applied biological sciences. Psychology Gene Function Gene loci Genes Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genomes Genomics Health sciences Homeostasis Human Genetics Humans Kidney - metabolism letter Magnetic Resonance Spectroscopy Male Membrane Transport Proteins - genetics Metabolites Nuclear magnetic resonance spectroscopy Physiological aspects Polymorphism, Single Nucleotide Population Surveillance Reproducibility of Results Risk factors Studies Urine Germany Human Urine Association
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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