Unlocking the therapeutic potential of primary tumor-draining lymph nodes

Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the dif...

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Bibliographic Details
Published in:	Cancer Immunology, Immunotherapy Vol. 68; no. 10; pp. 1681 - 1688
Main Authors:	Rotman, Jossie, Koster, Bas D., Jordanova, Ekaterina S., Heeren, A. Marijne, de Gruijl, Tanja D.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019 Springer Nature B.V
Subjects:	Antigens Breast cancer Cancer Research Cancer therapies Cervical cancer Dendritic cells Flow cytometry Focussed Research Review Immune response Immune response (cell-mediated) Immunity (Disease) Immunology Immunomodulation Immunotherapy Lymph nodes Lymphatic system Lymphocytes Lymphocytes T Medicine Medicine & Public Health Melanoma Metastasis Oncology Tumors Tumor-draining lymph node Breast cancer TIMO 2018 Local immunotherapy Cervical cancer Melanoma
ISSN:	0340-7004, 1432-0851, 1432-0851
Online Access:	Get full text
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