Unlocking the therapeutic potential of primary tumor-draining lymph nodes

Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the dif...

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Veröffentlicht in:Cancer Immunology, Immunotherapy Jg. 68; H. 10; S. 1681 - 1688
Hauptverfasser: Rotman, Jossie, Koster, Bas D., Jordanova, Ekaterina S., Heeren, A. Marijne, de Gruijl, Tanja D.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019
Springer Nature B.V
Schlagworte:
Antigens
Breast cancer
Cancer Research
Cancer therapies
Cervical cancer
Dendritic cells
Flow cytometry
Focussed Research Review
Immune response
Immune response (cell-mediated)
Immunity (Disease)
Immunology
Immunomodulation
Immunotherapy
Lymph nodes
Lymphatic system
Lymphocytes
Lymphocytes T
Medicine
Medicine & Public Health
Melanoma
Metastasis
Oncology
Tumors
Tumor-draining lymph node
Breast cancer
TIMO 2018
Local immunotherapy
Cervical cancer
Melanoma
ISSN:0340-7004, 1432-0851, 1432-0851
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Zusammenfassung:Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Here, we review our findings from translational studies in melanoma, breast, and cervical cancer and discuss clinical opportunities for local immune modulation of TDLN in each of these indications.
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0340-7004
1432-0851
1432-0851
DOI:10.1007/s00262-019-02330-y