Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe

Early diagnosis of tuberculosis can dramatically reduce both its transmission and the associated death rate. The extremely slow growth rate of the causative pathogen, Mycobacterium tuberculosis ( Mtb ), however, makes this challenging at the point of care, particularly in resource-limited settings....

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Veröffentlicht in:	Nature chemistry Jg. 4; H. 10; S. 802 - 809
Hauptverfasser:	Xie, Hexin, Mire, Joseph, Kong, Ying, Chang, MiHee, Hassounah, Hany A., Thornton, Chris N., Sacchettini, James C., Cirillo, Jeffrey D., Rao, Jianghong
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.10.2012 Nature Publishing Group
Schlagworte:	639/638/11 639/638/45 Analytical Chemistry Bacterial Proteins - metabolism beta-Lactamases - metabolism Binding Sites Biochemistry Catalytic Domain Chemistry Chemistry and Materials Science Chemistry/Food Science Computer Simulation Crystallization Emissions Enzymes Fluorescence Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Humans Hydrolysis Inorganic Chemistry Kinetics Mortality Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - isolation & purification Organic Chemistry Pathogens Physical Chemistry Point-of-Care Systems Probes Protein Structure, Tertiary Spectrometry, Fluorescence Sputum - microbiology Substrate Specificity Tuberculosis Tuberculosis - diagnosis United States > US Texas
ISSN:	1755-4330, 1755-4349, 1755-4349
Online-Zugang:	Volltext
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