Infrared spectral histopathology (SHP): a novel diagnostic tool for the accurate classification of lung cancer

We report results of a study utilizing a recently developed tissue diagnostic method, based on label-free spectral techniques, for the classification of lung cancer histopathological samples from a tissue microarray. The spectral diagnostic method allows reproducible and objective diagnosis of unsta...

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Published in:	Laboratory investigation Vol. 92; no. 9; pp. 1358 - 1373
Main Authors:	Bird, Benjamin, Miljković, Milos̆, Remiszewski, Stan, Akalin, Ali, Kon, Mark, Diem, Max
Format:	Journal Article
Language:	English
Published:	New York Elsevier Inc 01.09.2012 Nature Publishing Group US Nature Publishing Group
Subjects:	631/1647/1407/1555 631/1647/527/2257 692/699/67/1612 692/700/139 artificial neural network analysis Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology histopathology Humans immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Lung cancer Lung Neoplasms - classification Lung Neoplasms - diagnosis Medical sciences Medicine Medicine & Public Health Pathology Pneumology research-article spectral histopathology Spectrophotometry, Infrared - methods Tumors of the respiratory system and mediastinum lung cancer histopathology artificial neural network analysis immunohistochemistry spectral histopathology Immunohistochemistry Lung disease Biotechnology Respiratory disease Lung cancer 5: artificial neural network analysis Malignant tumor Neural network Anatomic pathology Histopathology Network analysis Clinical biology Classification Bronchus disease Infrared radiation Diagnosis Cancer Tool
ISSN:	0023-6837, 1530-0307, 1530-0307
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Abstract	We report results of a study utilizing a recently developed tissue diagnostic method, based on label-free spectral techniques, for the classification of lung cancer histopathological samples from a tissue microarray. The spectral diagnostic method allows reproducible and objective diagnosis of unstained tissue sections. This is accomplished by acquiring infrared hyperspectral data sets containing thousands of spectra, each collected from tissue pixels about 6 μm on edge; these pixel spectra contain an encoded snapshot of the entire biochemical composition of the pixel area. The hyperspectral data sets are subsequently decoded by methods of multivariate analysis, which reveal changes in the biochemical composition between tissue types, and between various stages and states of disease. In this study, a detailed comparison between classical and spectral histopathology (SHP) is presented, which suggests SHP can achieve levels of diagnostic accuracy that is comparable to that of multi-panel immunohistochemistry.
AbstractList	We report results of a study utilizing a recently developed tissue diagnostic method, based on label-free spectral techniques, for the classification of lung cancer histopathological samples from a tissue microarray. The spectral diagnostic method allows reproducible and objective diagnosis of unstained tissue sections. This is accomplished by acquiring infrared hyperspectral data sets containing thousands of spectra, each collected from tissue pixels about 6 μ m on edge; these pixel spectra contain an encoded snapshot of the entire biochemical composition of the pixel area. The hyperspectral data sets are subsequently decoded by methods of multivariate analysis, which reveal changes in the biochemical composition between tissue types, and between various stages and states of disease. In this study, a detailed comparison between classical and spectral histopathology (SHP) is presented, which suggests SHP can achieve levels of diagnostic accuracy that is comparable to that of multi-panel immunohistochemistry. We report results of a study utilizing a recently developed tissue diagnostic method, based on label-free spectral techniques, for the classification of lung cancer histopathological samples from a tissue microarray. The spectral diagnostic method allows reproducible and objective diagnosis of unstained tissue sections. This is accomplished by acquiring infrared hyperspectral data sets containing thousands of spectra, each collected from tissue pixels about 6 μm on edge; these pixel spectra contain an encoded snapshot of the entire biochemical composition of the pixel area. The hyperspectral data sets are subsequently decoded by methods of multivariate analysis, which reveal changes in the biochemical composition between tissue types, and between various stages and states of disease. In this study, a detailed comparison between classical and spectral histopathology (SHP) is presented, which suggests SHP can achieve levels of diagnostic accuracy that is comparable to that of multi-panel immunohistochemistry.We report results of a study utilizing a recently developed tissue diagnostic method, based on label-free spectral techniques, for the classification of lung cancer histopathological samples from a tissue microarray. The spectral diagnostic method allows reproducible and objective diagnosis of unstained tissue sections. This is accomplished by acquiring infrared hyperspectral data sets containing thousands of spectra, each collected from tissue pixels about 6 μm on edge; these pixel spectra contain an encoded snapshot of the entire biochemical composition of the pixel area. The hyperspectral data sets are subsequently decoded by methods of multivariate analysis, which reveal changes in the biochemical composition between tissue types, and between various stages and states of disease. In this study, a detailed comparison between classical and spectral histopathology (SHP) is presented, which suggests SHP can achieve levels of diagnostic accuracy that is comparable to that of multi-panel immunohistochemistry. We report results of a study utilizing a recently developed tissue diagnostic method, based on label-free spectral techniques, for the classification of lung cancer histopathological samples from a tissue microarray. The spectral diagnostic method allows reproducible and objective diagnosis of unstained tissue sections. This is accomplished by acquiring infrared hyperspectral data sets containing thousands of spectra, each collected from tissue pixels about 6μm on edge; these pixel spectra contain an encoded snapshot of the entire biochemical composition of the pixel area. The hyperspectral data sets are subsequently decoded by methods of multivariate analysis, which reveal changes in the biochemical composition between tissue types, and between various stages and states of disease. In this study, a detailed comparison between classical and spectral histopathology (SHP) is presented, which suggests SHP can achieve levels of diagnostic accuracy that is comparable to that of multi-panel immunohistochemistry. We report results of a study utilizing a recently developed tissue diagnostic method, based on label-free spectral techniques, for the classification of lung cancer histopathological samples from a tissue microarray. The spectral diagnostic method allows reproducible and objective diagnosis of unstained tissue sections. This is accomplished by acquiring infrared hyperspectral data sets containing thousands of spectra, each collected from tissue pixels about 6 μm on edge; these pixel spectra contain an encoded snapshot of the entire biochemical composition of the pixel area. The hyperspectral data sets are subsequently decoded by methods of multivariate analysis, which reveal changes in the biochemical composition between tissue types, and between various stages and states of disease. In this study, a detailed comparison between classical and spectral histopathology (SHP) is presented, which suggests SHP can achieve levels of diagnostic accuracy that is comparable to that of multi-panel immunohistochemistry.
Author	Bird, Benjamin Diem, Max Kon, Mark Miljković, Milos̆ Remiszewski, Stan Akalin, Ali
Author_xml	– sequence: 1 givenname: Benjamin surname: Bird fullname: Bird, Benjamin organization: Department of Chemistry and Chemical Biology, Laboratory for Spectral Diagnosis, Northeastern University, Boston, MA, USA – sequence: 2 givenname: Milos̆ surname: Miljković fullname: Miljković, Milos̆ organization: Department of Chemistry and Chemical Biology, Laboratory for Spectral Diagnosis, Northeastern University, Boston, MA, USA – sequence: 3 givenname: Stan surname: Remiszewski fullname: Remiszewski, Stan organization: Cireca Theranostics, Parsippany, NJ, USA – sequence: 4 givenname: Ali surname: Akalin fullname: Akalin, Ali organization: Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA – sequence: 5 givenname: Mark surname: Kon fullname: Kon, Mark organization: Department of Mathematics and Statistics, and Program in Bioinformatics, Boston University, Boston, MA, USA – sequence: 6 givenname: Max surname: Diem fullname: Diem, Max email: m.diem@neu.edu organization: Department of Chemistry and Chemical Biology, Laboratory for Spectral Diagnosis, Northeastern University, Boston, MA, USA
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Cites_doi	10.1002/9780470283172 10.1002/1097-0282(2000)57:5<282::AID-BIP50>3.0.CO;2-R 10.1002/bip.10435 10.1039/B921056C 10.1039/b821166c 10.1186/1472-6890-8-1 10.1002/jbio.200810070 10.1016/j.bbamem.2006.05.004 10.1109/3477.931536 10.1016/j.vibspec.2010.09.003 10.1366/000370209789806894 10.1002/9780470283172.ch6 10.1016/j.bbadis.2003.12.006 10.1016/j.ygyno.2003.12.028 10.1039/c0an00524j 10.1038/nbt1080 10.7785/tcrt.2012.500188 10.1016/j.bbabio.2007.06.004 10.1002/jbio.200810066 10.1016/j.chemphyslip.2004.12.002 10.1002/(SICI)1520-6343(1998)4:1<55::AID-BSPY6>3.0.CO;2-R 10.1016/j.bbamem.2006.05.001 10.1366/0003702011953018 10.1366/0003702021954322 10.1038/labinvest.2010.1 10.1021/ac801191x 10.1002/cem.993 10.1016/j.eururo.2006.03.031 10.1039/c0an00527d 10.1021/ac60214a047 10.1038/labinvest.2010.72 10.1039/c0an00350f 10.1097/PAS.0b013e3181f7dae3 10.1039/b821349f 10.1093/nar/gkr175 10.1016/j.bbamem.2006.05.003 10.3346/jkms.2007.22.2.318 10.1515/BC.1999.115 10.5858/2008-132-384-AOITTD 10.1039/c2an35582e
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Keywords	lung cancer histopathology artificial neural network analysis immunohistochemistry spectral histopathology Immunohistochemistry Lung disease Biotechnology Respiratory disease Lung cancer 5: artificial neural network analysis Malignant tumor Neural network Anatomic pathology Histopathology Network analysis Clinical biology Classification Bronchus disease Infrared radiation Diagnosis Cancer Tool
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References	Jefferson, Leung, Laskin (bib50) 2010; 34 Lasch, Diem, Hänsch (bib11) 2007; 20 Whelan, Bambery, Heraud (bib37) 2011; 39 Horsnell, Stonelake, Christie-Brown (bib26) 2010; 135 Wolthuis, Travo, Nicolet (bib16) 2008; 80 Romeo, Dukor, Diem (bib1) 2008 Bhargava, Levin (bib32) 2008 Pounder, Bhargava (bib20) 2010 Lasch, Haensch, Lewis (bib17) 2002; 56 Barr, Kendall, Stone (bib28) 2008 Adams (bib45) 2004 Hartsuiker, Zeijen, Terstappen (bib57) 2010; 135 Bambery, Schültke, Wood (bib23) 2006; 1758 Lasch, Naumann (bib18) 1998; 44 Chiriboga, Xie, Vigorita (bib52) 1998; 4 Lasch (bib40) 1999 Jamin, Miller, Moncuit (bib48) 2003; 72 Gerwert (bib36) 2001 Gerwert (bib35) 1999; 380 Miljković, Bird, Diem (bib44) 2012 Rerek, Van Wyck, Mendelsohn (bib38) 2005; 134 Amharref, Beljebbar, Dukic (bib22) 2006; 1758 Diem (bib33) 1993 Lasch, Haensch, Naumann (bib55) 2004; 1688 Lasch, Kneipp (bib24) 2008 Wood, Chiriboga, Yee (bib15) 2004; 93 Reddy, Bhargava (bib41) 2010; 135 Krafft, Shapoval, Sobottka (bib21) 2006; 1758 Bird, Romeo, Laver (bib12) 2009; 2 Savitzky, Golay (bib42) 1964; 36 Schubert, Bird, Papamarkakis (bib30) 2010; 90 Krafft, Diderhoshan, Recknagel (bib25) 2011; 55 Diem, Papamarkakis, Schubert (bib51) 2009; 63 Hutchings, Kendall, Smith (bib27) 2009; 2 Utzinger, Heintzelmann, Mahadevan-Jansen (bib7) 2001; 55 Schubert (bib31) 2011 Gazi, Baker, Dwyer (bib58) 2006; 50 Krafft, Salzer (bib56) 2008 Diem, Griffiths, Chalmers (bib9) 2008 Papamarkakis, Bird, Schubert (bib29) 2010; 90 Romeo, Boydston-White, Matthäus (bib5) 2008 Lee, Chen, Chen (bib47) 2001; 31 Wood, Chiriboga, Yee (bib46) 2004; 93 Barth (bib34) 2007; 1767 Diem, Chiriboga, Yee (bib39) 2000; 57 Bird, koviæ, Laver (bib13) 2011; 10 Jagidar (bib3) 2008; 132 Fernandez, Bhargava, Hewitt (bib19) 2005; 23 Park, Follen, Milbourne (bib6) 2008; 13 Bassan, Kohler, Martens (bib54) 2010; 135 Bassan, Byrne, Lee (bib53) 2009; 134 Yoo, Jung, Lee (bib4) 2007; 22 Bird, Bedrossian, Laver (bib14) 2009; 134 Diem, Bird, Miljković (bib43) 2011 Lasch, Beekes, Fabian (bib49) 2008 Bird, Miljkovic, Romeo (bib10) 2008; 8 Bahlmann, Patel, Johnson (bib2) 2012; 8315 Chiriboga, Xie, Yee (bib8) 1998; 44 Chiriboga, Xie, Yee (CR8) 1998; 44 Bhargava, Levin (CR32) 2008 Jamin, Miller, Moncuit (CR48) 2003; 72 Utzinger, Heintzelmann, Mahadevan-Jansen (CR7) 2001; 55 Reddy, Bhargava (CR41) 2010; 135 Diem, Chiriboga, Yee (CR39) 2000; 57 Barth (CR34) 2007; 1767 Krafft, Shapoval, Sobottka (CR21) 2006; 1758 Whelan, Bambery, Heraud (CR37) 2011; 39 Bird, Miljkovic, Romeo (CR10) 2008; 8 Diem (CR33) 1993 Schubert, Bird, Papamarkakis (CR30) 2010; 90 Fernandez, Bhargava, Hewitt (CR19) 2005; 23 Lasch (CR40) 1999 CR6 Bahlmann, Patel, Johnson (CR2) 2012; 8315 Schubert (CR31) 2011 Lasch, Beekes, Fabian (CR49) 2008 Lasch, Diem, Hänsch (CR11) 2007; 20 CR44 Horsnell, Stonelake, Christie-Brown (CR26) 2010; 135 Gerwert (CR35) 1999; 380 Jefferson, Leung, Laskin (CR50) 2010; 34 Hartsuiker, Zeijen, Terstappen (CR57) 2010; 135 Lasch, Naumann (CR18) 1998; 44 Lee, Chen, Chen (CR47) 2001; 31 Krafft, Diderhoshan, Recknagel (CR25) 2011; 55 Pounder, Bhargava (CR20) 2010 Wood, Chiriboga, Yee (CR46) 2004; 93 Romeo, Boydston-White, Matthäus (CR5) 2008 Bird, Romeo, Laver (CR12) 2009; 2 Wolthuis, Travo, Nicolet (CR16) 2008; 80 Savitzky, Golay (CR42) 1964; 36 Lasch, Haensch, Lewis (CR17) 2002; 56 Amharref, Beljebbar, Dukic (CR22) 2006; 1758 Romeo, Dukor, Diem (CR1) 2008 Papamarkakis, Bird, Schubert (CR29) 2010; 90 Jagidar (CR3) 2008; 132 Bird, Bedrossian, Laver (CR14) 2009; 134 Diem, Papamarkakis, Schubert (CR51) 2009; 63 Chiriboga, Xie, Vigorita (CR52) 1998; 4 Barr, Kendall, Stone (CR28) 2008 Gazi, Baker, Dwyer (CR58) 2006; 50 Yoo, Jung, Lee (CR4) 2007; 22 Rerek, Van Wyck, Mendelsohn (CR38) 2005; 134 Adams (CR45) 2004 Krafft, Salzer (CR56) 2008 Diem, Bird, Miljković (CR43) 2011 Bassan, Byrne, Lee (CR53) 2009; 134 Bambery, Schültke, Wood (CR23) 2006; 1758 Lasch, Kneipp (CR24) 2008 Wood, Chiriboga, Yee (CR15) 2004; 93 Bassan, Kohler, Martens (CR54) 2010; 135 Hutchings, Kendall, Smith (CR27) 2009; 2 Diem, Griffiths, Chalmers (CR9) 2008 Gerwert (CR36) 2001 Bird, koviæ, Laver (CR13) 2011; 10 Lasch, Haensch, Naumann (CR55) 2004; 1688 Wood (10.1038/labinvest.2012.101_bib46) 2004; 93 Wolthuis (10.1038/labinvest.2012.101_bib16) 2008; 80 Schubert (10.1038/labinvest.2012.101_bib30) 2010; 90 Schubert (10.1038/labinvest.2012.101_bib31) 2011 Lee (10.1038/labinvest.2012.101_bib47) 2001; 31 Lasch (10.1038/labinvest.2012.101_bib17) 2002; 56 Barth (10.1038/labinvest.2012.101_bib34) 2007; 1767 Gerwert (10.1038/labinvest.2012.101_bib35) 1999; 380 Hutchings (10.1038/labinvest.2012.101_bib27) 2009; 2 Park (10.1038/labinvest.2012.101_bib6) 2008; 13 Diem (10.1038/labinvest.2012.101_bib9) 2008 Pounder (10.1038/labinvest.2012.101_bib20) 2010 Utzinger (10.1038/labinvest.2012.101_bib7) 2001; 55 Krafft (10.1038/labinvest.2012.101_bib56) 2008 Gerwert (10.1038/labinvest.2012.101_bib36) 2001 Miljković (10.1038/labinvest.2012.101_bib44) 2012 Papamarkakis (10.1038/labinvest.2012.101_bib29) 2010; 90 Hartsuiker (10.1038/labinvest.2012.101_bib57) 2010; 135 Adams (10.1038/labinvest.2012.101_bib45) 2004 Bambery (10.1038/labinvest.2012.101_bib23) 2006; 1758 Diem (10.1038/labinvest.2012.101_bib33) 1993 Yoo (10.1038/labinvest.2012.101_bib4) 2007; 22 Krafft (10.1038/labinvest.2012.101_bib25) 2011; 55 Chiriboga (10.1038/labinvest.2012.101_bib52) 1998; 4 Diem (10.1038/labinvest.2012.101_bib43) 2011 Lasch (10.1038/labinvest.2012.101_bib55) 2004; 1688 Krafft (10.1038/labinvest.2012.101_bib21) 2006; 1758 Lasch (10.1038/labinvest.2012.101_bib24) 2008 Jefferson (10.1038/labinvest.2012.101_bib50) 2010; 34 Romeo (10.1038/labinvest.2012.101_bib1) 2008 Savitzky (10.1038/labinvest.2012.101_bib42) 1964; 36 Gazi (10.1038/labinvest.2012.101_bib58) 2006; 50 Bird (10.1038/labinvest.2012.101_bib10) 2008; 8 Romeo (10.1038/labinvest.2012.101_bib5) 2008 Rerek (10.1038/labinvest.2012.101_bib38) 2005; 134 Diem (10.1038/labinvest.2012.101_bib39) 2000; 57 Amharref (10.1038/labinvest.2012.101_bib22) 2006; 1758 Horsnell (10.1038/labinvest.2012.101_bib26) 2010; 135 Lasch (10.1038/labinvest.2012.101_bib18) 1998; 44 Chiriboga (10.1038/labinvest.2012.101_bib8) 1998; 44 Whelan (10.1038/labinvest.2012.101_bib37) 2011; 39 Bird (10.1038/labinvest.2012.101_bib14) 2009; 134 Lasch (10.1038/labinvest.2012.101_bib40) 1999 Bassan (10.1038/labinvest.2012.101_bib53) 2009; 134 Jamin (10.1038/labinvest.2012.101_bib48) 2003; 72 Wood (10.1038/labinvest.2012.101_bib15) 2004; 93 Reddy (10.1038/labinvest.2012.101_bib41) 2010; 135 Bird (10.1038/labinvest.2012.101_bib13) 2011; 10 Bassan (10.1038/labinvest.2012.101_bib54) 2010; 135 Bahlmann (10.1038/labinvest.2012.101_bib2) 2012; 8315 Barr (10.1038/labinvest.2012.101_bib28) 2008 Jagidar (10.1038/labinvest.2012.101_bib3) 2008; 132 Diem (10.1038/labinvest.2012.101_bib51) 2009; 63 Bird (10.1038/labinvest.2012.101_bib12) 2009; 2 Lasch (10.1038/labinvest.2012.101_bib11) 2007; 20 Fernandez (10.1038/labinvest.2012.101_bib19) 2005; 23 Bhargava (10.1038/labinvest.2012.101_bib32) 2008 Lasch (10.1038/labinvest.2012.101_bib49) 2008
References_xml	– volume: 44 start-page: 189 year: 1998 end-page: 202 ident: bib18 article-title: FT-IR microspectroscopic imaging of human carcinoma in thin sections based on pattern recognition techniques publication-title: Cell Mol Biol – year: 2008 ident: bib9 publication-title: Vibrational Spectroscopy for Medical Diagnosis – volume: 4 start-page: 55 year: 1998 end-page: 59 ident: bib52 article-title: Infrared spectroscopy of human tissue. II. A comparative study of spectra of biopsies of cervical squamous epithelium and of exfoliated cervical cells publication-title: Biospectroscopy – volume: 39 start-page: 5439 year: 2011 end-page: 5448 ident: bib37 article-title: Monitoring the reversible B to A-like transition of DNA in eukaryotic cells using Fourier transform infrared spectroscopy publication-title: Nucleic Acids Res – volume: 8 start-page: 1 year: 2008 end-page: 14 ident: bib10 article-title: Infrared micro-spectral imaging: automatic distinction of tissuetypes in axillary lymph node histology' publication-title: BMC J Clin Pathol – volume: 134 start-page: 51 year: 2005 end-page: 58 ident: bib38 article-title: FTIR spectroscopic studies of lipid dynamics in phytosphingosine ceramide models of the stratum corneum lipid matrix publication-title: Chem Phy Lipids – start-page: 97 year: 2008 end-page: 122 ident: bib49 article-title: Antemortem identification of transmissible spongiform encephalopathy (TSE) from serum by mid-infrared spectroscopy publication-title: Vibrational Spectroscopy for Medical Diagnosis – volume: 2 start-page: 91 year: 2009 end-page: 103 ident: bib27 article-title: The potential for histological screening using a combination of rapid Raman mapping and principal component analysis publication-title: J Biophoton – volume: 44 start-page: 219 year: 1998 end-page: 229 ident: bib8 article-title: IR spectroscopy of human tissue. IV. Detection of dysplastic and neoplastic changes of human cervical tissue via infrared microspectroscopy publication-title: Cell Mol Biol – volume: 135 start-page: 2815 year: 2010 end-page: 2818 ident: bib41 article-title: Accurate histopathology from low signal-to-noise ratio spectroscopic imaging data publication-title: Analyst – volume: 135 start-page: 268 year: 2010 end-page: 277 ident: bib54 article-title: Resonant Mie Scattering (RMieS) correction of infrared spectra from highly scattering biological samples publication-title: Analyst – volume: 1758 start-page: 900 year: 2006 end-page: 907 ident: bib23 article-title: A Fourier transform infrared microscopic image investigation into an animal model exhibiting glioblastoma multiforme publication-title: Biochem Biophys Acta – volume: 93 start-page: 59 year: 2004 end-page: 68 ident: bib46 article-title: Fourier transform infrared (FTIR) spectral mapping of the cervical transformation zone, and dysplastic squamous epithelium publication-title: Gynecol Oncol – start-page: 155 year: 2008 end-page: 186 ident: bib32 article-title: Infrared spectroscopic imaging protocols for high-troughput histopathology publication-title: Vibrational Spectroscopy for Medical Diagnosis – year: 2008 ident: bib56 article-title: Neuro-oncological applications of infrared and Raman spectroscopy publication-title: Vibrational Spectroscopy for Medical Diagnosis – start-page: 1 year: 2008 end-page: 26 ident: bib1 article-title: Introduction to spectral imaging, and applications to diagnosis of lymph nodes publication-title: Vibrational Spectroscopy for Medical Diagnosis – volume: 31 start-page: 426 year: 2001 end-page: 432 ident: bib47 article-title: An efficient fuzzy classifier with feature selection based on fuzzy entropy publication-title: IEEE Trans Systems Man Cybernetics – volume: 1758 start-page: 883 year: 2006 end-page: 891 ident: bib21 article-title: Indentification of primary tumors of brain metastases by SIMCA classification of IR spectroscopic images publication-title: Biochem Biophys Acta – volume: 36 start-page: 1627 year: 1964 end-page: 1639 ident: bib42 article-title: Smoothing and differentiation of data by simplified least-squares procedures publication-title: Anal Chem – volume: 135 start-page: 3220 year: 2010 end-page: 3226 ident: bib57 article-title: A comparison of breast cancer tumor cells with varying expression of the Her2/neu receptor by Raman microspectroscopic imaging publication-title: Analyst – volume: 63 start-page: 307A year: 2009 end-page: 318A ident: bib51 article-title: The infrared spectral signatures of disease: extracting the distinguishing spectral features between normal and diseased states publication-title: Appl Spectrosc – start-page: 193 year: 2001 end-page: 230 ident: bib36 article-title: Molecular reaction mechanisms of proteins monitored by time-resolved FT-IR difference spectroscopy publication-title: Infrared and Raman Spectroscopy of Biological Materials – volume: 1688 start-page: 176 year: 2004 end-page: 186 ident: bib55 article-title: Imaging of colorectal adenocarcinoma using FT-IR microspectroscopy and cluster analysis publication-title: Biochim Biophys Acta – year: 2011 ident: bib43 publication-title: Phase correction to compensate for reflective distortions of optical spectra – volume: 10 start-page: 135 year: 2011 end-page: 144 ident: bib13 article-title: Spectral detection of micro-metastases and individual metastatic cells in lymph node histology publication-title: Tech Cancer Res Treatment – volume: 1758 start-page: 892 year: 2006 end-page: 899 ident: bib22 article-title: Brain tissue characterization by infrared imaging in a rat glioma model publication-title: Biochem Biophys Acta – volume: 34 start-page: 1805 year: 2010 end-page: 1811 ident: bib50 article-title: Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples publication-title: Am J Surg Path – volume: 93 start-page: 59 year: 2004 end-page: 68 ident: bib15 article-title: FTIR mapping of the cervical transformation zone, squamous and glandular epithelium publication-title: Gynecol Oncol – volume: 55 start-page: 90 year: 2011 end-page: 100 ident: bib25 article-title: Crisp and soft multivariate methods visualize individual cell nuclei in Raman images of liver tissue sections publication-title: Vibr Spectrosc – volume: 50 start-page: 750 year: 2006 end-page: 761 ident: bib58 article-title: A correlation of FTIR spectra derived from prostate cancer tissue with Gleason grade, PSA and tumour stage publication-title: Eur Urol – year: 1993 ident: bib33 publication-title: Introduction to Modern Vibrational Spectroscopy – year: 2010 ident: bib20 article-title: Toward automated breast histopathology using mid-IR spectroscopic imaging publication-title: Vibrational Spectroscopic Imaging for Biomedical Applications – volume: 8315 start-page: 831504 year: 2012 ident: bib2 article-title: Automated detection of diagnostically relevant regions in H&E stained digital pathology slides publication-title: Proc SPIE ‘Medical Imaging 2012: Computer-Aided Diagnosis' – volume: 13 year: 2008 ident: bib6 article-title: Automated image analysis of digital colposcopy for the detection of cervical neoplasia. publication-title: J Biomed Optics – volume: 72 start-page: 366 year: 2003 end-page: 373 ident: bib48 article-title: Chemical heterogeneity in cell death: combined synchrotron IR and fluorescence microscopy studies of single apoptotic and necrotic cells publication-title: Biopolymers (Biospectroscopy) – volume: 90 start-page: 589 year: 2010 end-page: 598 ident: bib29 article-title: Cytopathology by optical methods: spectral cytopathology of the oral mucosa publication-title: Lab Invest – volume: 22 start-page: 318 year: 2007 end-page: 325 ident: bib4 article-title: Immunohistochemical analysis of non-small cell lung cancer: correlation with clinical parameters and prognosis publication-title: J Korean Med Sci – volume: 132 start-page: 384 year: 2008 end-page: 396 ident: bib3 article-title: Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung publication-title: Arch Pathol Lab Med – year: 2011 ident: bib31 publication-title: Spectral cytology of human oral and cervical samples – year: 2012 ident: bib44 article-title: Dispersive line shape effects in infrared spectroscopy. publication-title: Analyst – volume: 135 start-page: 3042 year: 2010 end-page: 3047 ident: bib26 article-title: Raman spectroscopy - a new method for the intra-operative assessment of axillary lymph nodes publication-title: Analyst – volume: 80 start-page: 8461 year: 2008 end-page: 8469 ident: bib16 article-title: IR spectral imaging for histopathological characterization of xenografted human colon carcinomas publication-title: Anal Chem – start-page: 203 year: 2008 end-page: 230 ident: bib28 article-title: Raman spectroscopy as a potential tool for early diagnosis of malignancies in esophageal and bladder tissues publication-title: Vibrational Spectroscopy for Medical Diagnosis – volume: 2 start-page: 37 year: 2009 end-page: 46 ident: bib12 article-title: Spectral detection of micro-metastases in lymph node histopathology publication-title: J Biophotonics – volume: 90 start-page: 1068 year: 2010 end-page: 1077 ident: bib30 article-title: Spectral cytopathology of cervical samples: detecting cellular abnormalities in cytologically normal cells publication-title: Lab Invest – volume: 134 start-page: 1171 year: 2009 end-page: 1175 ident: bib53 article-title: Reflection contributions to the dispersion artefact in FTIR spectra of single biological cells publication-title: Analyst – year: 1999 ident: bib40 publication-title: Computergestuetzte Bildrekonstuktion auf Basis FTIR-mikrospektrometrischer Daten humaner Tumoren – volume: 56 start-page: 1 year: 2002 end-page: 9 ident: bib17 article-title: Characterization of colorectal adenocarcinoma sections by spatially resolved FT-IR microspectroscopy publication-title: Appl Spectrosc – volume: 1767 start-page: 1073 year: 2007 end-page: 1101 ident: bib34 article-title: Infrared spectroscopy of proteins publication-title: Biochim Biophys Acta – volume: 134 start-page: 1067 year: 2009 end-page: 1076 ident: bib14 article-title: Detection of breast micro-metastases in axillary lymph nodes by infrared micro-spectral imaging publication-title: Analyst – volume: 380 start-page: 931 year: 1999 end-page: 935 ident: bib35 article-title: Molecular reaction mechanisms of proteins monitored by time-resolved FTIR spectroscopy publication-title: Biol Chem – volume: 23 start-page: 469 year: 2005 end-page: 474 ident: bib19 article-title: Infrared spectroscopic imaging for histopatholog recognition publication-title: Nat Biotech – year: 2004 ident: bib45 publication-title: Chemometrics in Analytical Spectroscopy, 2 – volume: 57 start-page: 282 year: 2000 end-page: 290 ident: bib39 article-title: Infrared spectroscopy of human cells and tissue VIII. Strategies for analysis of infrared tissue mapping data and applications to liver tissue publication-title: Biopolymers – start-page: 121 year: 2008 end-page: 147 ident: bib5 article-title: Vibrational microspectroscopy of cells and tissues publication-title: Biomedical Vibrational Spectroscopy – volume: 55 start-page: 955 year: 2001 end-page: 959 ident: bib7 article-title: Near IR Raman spectroscopy for publication-title: Appl Spectrosc – volume: 20 start-page: 209 year: 2007 end-page: 220 ident: bib11 article-title: Artificial neural networks as supervised techniques for FT-IR microspectroscopic imaging publication-title: J Chemometrics – start-page: 121 year: 2008 end-page: 147 ident: bib24 article-title: Biomedical vibrational spectroscopy publication-title: Biomedical Vibrational Spectroscopy – volume: 132 start-page: 384 year: 2008 end-page: 396 ident: CR3 article-title: Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung publication-title: Arch Pathol Lab Med – start-page: 97 year: 2008 end-page: 122 ident: CR49 article-title: Antemortem identification of transmissible spongiform encephalopathy (TSE) from serum by mid-infrared spectroscopy publication-title: Vibrational Spectroscopy for Medical Diagnosis doi: 10.1002/9780470283172 – volume: 44 start-page: 219 year: 1998 end-page: 229 ident: CR8 article-title: IR spectroscopy of human tissue. IV. Detection of dysplastic and neoplastic changes of human cervical tissue via infrared microspectroscopy publication-title: Cell Mol Biol – volume: 57 start-page: 282 year: 2000 end-page: 290 ident: CR39 article-title: Infrared spectroscopy of human cells and tissue VIII. Strategies for analysis of infrared tissue mapping data and applications to liver tissue publication-title: Biopolymers doi: 10.1002/1097-0282(2000)57:5<282::AID-BIP50>3.0.CO;2-R – volume: 72 start-page: 366 year: 2003 end-page: 373 ident: CR48 article-title: Chemical heterogeneity in cell death: combined synchrotron IR and fluorescence microscopy studies of single apoptotic and necrotic cells publication-title: Biopolymers (Biospectroscopy) doi: 10.1002/bip.10435 – volume: 135 start-page: 268 year: 2010 end-page: 277 ident: CR54 article-title: Resonant Mie Scattering (RMieS) correction of infrared spectra from highly scattering biological samples publication-title: Analyst doi: 10.1039/B921056C – volume: 134 start-page: 1067 year: 2009 end-page: 1076 ident: CR14 article-title: Detection of breast micro-metastases in axillary lymph nodes by infrared micro-spectral imaging publication-title: Analyst doi: 10.1039/b821166c – volume: 8 start-page: 1 year: 2008 end-page: 14 ident: CR10 article-title: Infrared micro-spectral imaging: automatic distinction of tissuetypes in axillary lymph node histology’ publication-title: BMC J Clin Pathol doi: 10.1186/1472-6890-8-1 – volume: 2 start-page: 91 year: 2009 end-page: 103 ident: CR27 article-title: The potential for histological screening using a combination of rapid Raman mapping and principal component analysis publication-title: J Biophoton doi: 10.1002/jbio.200810070 – volume: 1758 start-page: 900 year: 2006 end-page: 907 ident: CR23 article-title: A Fourier transform infrared microscopic image investigation into an animal model exhibiting glioblastoma multiforme publication-title: Biochem Biophys Acta doi: 10.1016/j.bbamem.2006.05.004 – volume: 31 start-page: 426 year: 2001 end-page: 432 ident: CR47 article-title: An efficient fuzzy classifier with feature selection based on fuzzy entropy publication-title: IEEE Trans Systems Man Cybernetics doi: 10.1109/3477.931536 – year: 2011 ident: CR43 publication-title: Phase correction to compensate for reflective distortions of optical spectra – volume: 55 start-page: 90 year: 2011 end-page: 100 ident: CR25 article-title: Crisp and soft multivariate methods visualize individual cell nuclei in Raman images of liver tissue sections publication-title: Vibr Spectrosc doi: 10.1016/j.vibspec.2010.09.003 – volume: 63 start-page: 307A year: 2009 end-page: 318A ident: CR51 article-title: The infrared spectral signatures of disease: extracting the distinguishing spectral features between normal and diseased states publication-title: Appl Spectrosc doi: 10.1366/000370209789806894 – start-page: 121 year: 2008 end-page: 147 ident: CR5 article-title: Vibrational microspectroscopy of cells and tissues publication-title: Biomedical Vibrational Spectroscopy doi: 10.1002/9780470283172.ch6 – volume: 1688 start-page: 176 year: 2004 end-page: 186 ident: CR55 article-title: Imaging of colorectal adenocarcinoma using FT-IR microspectroscopy and cluster analysis publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2003.12.006 – year: 1993 ident: CR33 publication-title: Introduction to Modern Vibrational Spectroscopy – volume: 93 start-page: 59 year: 2004 end-page: 68 ident: CR46 article-title: Fourier transform infrared (FTIR) spectral mapping of the cervical transformation zone, and dysplastic squamous epithelium publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2003.12.028 – volume: 135 start-page: 3220 year: 2010 end-page: 3226 ident: CR57 article-title: A comparison of breast cancer tumor cells with varying expression of the Her2/neu receptor by Raman microspectroscopic imaging publication-title: Analyst doi: 10.1039/c0an00524j – volume: 23 start-page: 469 year: 2005 end-page: 474 ident: CR19 article-title: Infrared spectroscopic imaging for histopatholog recognition publication-title: Nat Biotech doi: 10.1038/nbt1080 – volume: 10 start-page: 135 year: 2011 end-page: 144 ident: CR13 article-title: Spectral detection of micro-metastases and individual metastatic cells in lymph node histology publication-title: Tech Cancer Res Treatment doi: 10.7785/tcrt.2012.500188 – year: 2008 ident: CR56 article-title: Neuro-oncological applications of infrared and Raman spectroscopy publication-title: Vibrational Spectroscopy for Medical Diagnosis – volume: 1767 start-page: 1073 year: 2007 end-page: 1101 ident: CR34 article-title: Infrared spectroscopy of proteins publication-title: Biochim Biophys Acta doi: 10.1016/j.bbabio.2007.06.004 – volume: 8315 start-page: 831504 year: 2012 ident: CR2 article-title: Automated detection of diagnostically relevant regions in H&E stained digital pathology slides publication-title: Proc SPIE ‘Medical Imaging 2012: Computer-Aided Diagnosis’ – volume: 2 start-page: 37 year: 2009 end-page: 46 ident: CR12 article-title: Spectral detection of micro-metastases in lymph node histopathology publication-title: J Biophotonics doi: 10.1002/jbio.200810066 – volume: 134 start-page: 51 year: 2005 end-page: 58 ident: CR38 article-title: FTIR spectroscopic studies of lipid dynamics in phytosphingosine ceramide models of the stratum corneum lipid matrix publication-title: Chem Phy Lipids doi: 10.1016/j.chemphyslip.2004.12.002 – volume: 4 start-page: 55 year: 1998 end-page: 59 ident: CR52 article-title: Infrared spectroscopy of human tissue. II. A comparative study of spectra of biopsies of cervical squamous epithelium and of exfoliated cervical cells publication-title: Biospectroscopy doi: 10.1002/(SICI)1520-6343(1998)4:1<55::AID-BSPY6>3.0.CO;2-R – volume: 1758 start-page: 883 year: 2006 end-page: 891 ident: CR21 article-title: Indentification of primary tumors of brain metastases by SIMCA classification of IR spectroscopic images publication-title: Biochem Biophys Acta doi: 10.1016/j.bbamem.2006.05.001 – year: 2011 ident: CR31 publication-title: Spectral cytology of human oral and cervical samples – volume: 55 start-page: 955 year: 2001 end-page: 959 ident: CR7 article-title: Near IR Raman spectroscopy for detection of cervical precancers publication-title: Appl Spectrosc doi: 10.1366/0003702011953018 – year: 2004 ident: CR45 publication-title: Chemometrics in Analytical Spectroscopy, 2 edn – volume: 56 start-page: 1 year: 2002 end-page: 9 ident: CR17 article-title: Characterization of colorectal adenocarcinoma sections by spatially resolved FT-IR microspectroscopy publication-title: Appl Spectrosc doi: 10.1366/0003702021954322 – start-page: 203 year: 2008 end-page: 230 ident: CR28 article-title: Raman spectroscopy as a potential tool for early diagnosis of malignancies in esophageal and bladder tissues publication-title: Vibrational Spectroscopy for Medical Diagnosis – year: 2008 ident: CR9 publication-title: Vibrational Spectroscopy for Medical Diagnosis – volume: 90 start-page: 589 year: 2010 end-page: 598 ident: CR29 article-title: Cytopathology by optical methods: spectral cytopathology of the oral mucosa publication-title: Lab Invest doi: 10.1038/labinvest.2010.1 – start-page: 193 year: 2001 end-page: 230 ident: CR36 article-title: Molecular reaction mechanisms of proteins monitored by time-resolved FT-IR difference spectroscopy publication-title: Infrared and Raman Spectroscopy of Biological Materials – volume: 80 start-page: 8461 year: 2008 end-page: 8469 ident: CR16 article-title: IR spectral imaging for histopathological characterization of xenografted human colon carcinomas publication-title: Anal Chem doi: 10.1021/ac801191x – start-page: 1 year: 2008 end-page: 26 ident: CR1 article-title: Introduction to spectral imaging, and applications to diagnosis of lymph nodes publication-title: Vibrational Spectroscopy for Medical Diagnosis – volume: 20 start-page: 209 year: 2007 end-page: 220 ident: CR11 article-title: Artificial neural networks as supervised techniques for FT-IR microspectroscopic imaging publication-title: J Chemometrics doi: 10.1002/cem.993 – ident: CR6 – volume: 50 start-page: 750 year: 2006 end-page: 761 ident: CR58 article-title: A correlation of FTIR spectra derived from prostate cancer tissue with Gleason grade, PSA and tumour stage publication-title: Eur Urol doi: 10.1016/j.eururo.2006.03.031 – volume: 135 start-page: 3042 year: 2010 end-page: 3047 ident: CR26 article-title: Raman spectroscopy - a new method for the intra-operative assessment of axillary lymph nodes publication-title: Analyst doi: 10.1039/c0an00527d – volume: 93 start-page: 59 year: 2004 end-page: 68 ident: CR15 article-title: FTIR mapping of the cervical transformation zone, squamous and glandular epithelium publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2003.12.028 – volume: 36 start-page: 1627 year: 1964 end-page: 1639 ident: CR42 article-title: Smoothing and differentiation of data by simplified least-squares procedures publication-title: Anal Chem doi: 10.1021/ac60214a047 – ident: CR44 – volume: 90 start-page: 1068 year: 2010 end-page: 1077 ident: CR30 article-title: Spectral cytopathology of cervical samples: detecting cellular abnormalities in cytologically normal cells publication-title: Lab Invest doi: 10.1038/labinvest.2010.72 – volume: 135 start-page: 2818 year: 2010 end-page: 2815 ident: CR41 article-title: Accurate histopathology from low signal-to-noise ratio spectroscopic imaging data publication-title: Analyst doi: 10.1039/c0an00350f – year: 2010 ident: CR20 article-title: Toward automated breast histopathology using mid-IR spectroscopic imaging publication-title: Vibrational Spectroscopic Imaging for Biomedical Applications – volume: 34 start-page: 1805 year: 2010 end-page: 1811 ident: CR50 article-title: Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples publication-title: Am J Surg Path doi: 10.1097/PAS.0b013e3181f7dae3 – year: 1999 ident: CR40 publication-title: Computergestuetzte Bildrekonstuktion auf Basis FTIR-mikrospektrometrischer Daten humaner Tumoren – volume: 134 start-page: 1171 year: 2009 end-page: 1175 ident: CR53 article-title: Reflection contributions to the dispersion artefact in FTIR spectra of single biological cells publication-title: Analyst doi: 10.1039/b821349f – volume: 44 start-page: 189 year: 1998 end-page: 202 ident: CR18 article-title: FT-IR microspectroscopic imaging of human carcinoma in thin sections based on pattern recognition techniques publication-title: Cell Mol Biol – volume: 39 start-page: 5439 year: 2011 end-page: 5448 ident: CR37 article-title: Monitoring the reversible B to A-like transition of DNA in eukaryotic cells using Fourier transform infrared spectroscopy publication-title: Nucleic Acids Res doi: 10.1093/nar/gkr175 – start-page: 155 year: 2008 end-page: 186 ident: CR32 article-title: Infrared spectroscopic imaging protocols for high-troughput histopathology publication-title: Vibrational Spectroscopy for Medical Diagnosis – volume: 1758 start-page: 892 year: 2006 end-page: 899 ident: CR22 article-title: Brain tissue characterization by infrared imaging in a rat glioma model publication-title: Biochem Biophys Acta doi: 10.1016/j.bbamem.2006.05.003 – start-page: 121 year: 2008 end-page: 147 ident: CR24 article-title: Biomedical vibrational spectroscopy publication-title: Biomedical Vibrational Spectroscopy doi: 10.1002/9780470283172 – volume: 22 start-page: 318 year: 2007 end-page: 325 ident: CR4 article-title: Immunohistochemical analysis of non-small cell lung cancer: correlation with clinical parameters and prognosis publication-title: J Korean Med Sci doi: 10.3346/jkms.2007.22.2.318 – volume: 380 start-page: 931 year: 1999 end-page: 935 ident: CR35 article-title: Molecular reaction mechanisms of proteins monitored by time-resolved FTIR spectroscopy publication-title: Biol Chem doi: 10.1515/BC.1999.115 – volume: 132 start-page: 384 year: 2008 ident: 10.1038/labinvest.2012.101_bib3 article-title: Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung publication-title: Arch Pathol Lab Med doi: 10.5858/2008-132-384-AOITTD – volume: 20 start-page: 209 year: 2007 ident: 10.1038/labinvest.2012.101_bib11 article-title: Artificial neural networks as supervised techniques for FT-IR microspectroscopic imaging publication-title: J Chemometrics doi: 10.1002/cem.993 – start-page: 193 year: 2001 ident: 10.1038/labinvest.2012.101_bib36 article-title: Molecular reaction mechanisms of proteins monitored by time-resolved FT-IR difference spectroscopy – volume: 50 start-page: 750 year: 2006 ident: 10.1038/labinvest.2012.101_bib58 article-title: A correlation of FTIR spectra derived from prostate cancer tissue with Gleason grade, PSA and tumour stage publication-title: Eur Urol doi: 10.1016/j.eururo.2006.03.031 – volume: 57 start-page: 282 year: 2000 ident: 10.1038/labinvest.2012.101_bib39 article-title: Infrared spectroscopy of human cells and tissue VIII. Strategies for analysis of infrared tissue mapping data and applications to liver tissue publication-title: Biopolymers doi: 10.1002/1097-0282(2000)57:5<282::AID-BIP50>3.0.CO;2-R – volume: 90 start-page: 589 year: 2010 ident: 10.1038/labinvest.2012.101_bib29 article-title: Cytopathology by optical methods: spectral cytopathology of the oral mucosa publication-title: Lab Invest doi: 10.1038/labinvest.2010.1 – year: 2011 ident: 10.1038/labinvest.2012.101_bib43 – volume: 44 start-page: 219 year: 1998 ident: 10.1038/labinvest.2012.101_bib8 article-title: IR spectroscopy of human tissue. IV. Detection of dysplastic and neoplastic changes of human cervical tissue via infrared microspectroscopy publication-title: Cell Mol Biol – volume: 13 year: 2008 ident: 10.1038/labinvest.2012.101_bib6 article-title: Automated image analysis of digital colposcopy for the detection of cervical neoplasia. publication-title: J Biomed Optics – volume: 134 start-page: 1067 year: 2009 ident: 10.1038/labinvest.2012.101_bib14 article-title: Detection of breast micro-metastases in axillary lymph nodes by infrared micro-spectral imaging publication-title: Analyst doi: 10.1039/b821166c – volume: 22 start-page: 318 year: 2007 ident: 10.1038/labinvest.2012.101_bib4 article-title: Immunohistochemical analysis of non-small cell lung cancer: correlation with clinical parameters and prognosis publication-title: J Korean Med Sci doi: 10.3346/jkms.2007.22.2.318 – volume: 55 start-page: 90 year: 2011 ident: 10.1038/labinvest.2012.101_bib25 article-title: Crisp and soft multivariate methods visualize individual cell nuclei in Raman images of liver tissue sections publication-title: Vibr Spectrosc doi: 10.1016/j.vibspec.2010.09.003 – start-page: 203 year: 2008 ident: 10.1038/labinvest.2012.101_bib28 article-title: Raman spectroscopy as a potential tool for early diagnosis of malignancies in esophageal and bladder tissues – start-page: 121 year: 2008 ident: 10.1038/labinvest.2012.101_bib24 article-title: Biomedical vibrational spectroscopy – start-page: 155 year: 2008 ident: 10.1038/labinvest.2012.101_bib32 article-title: Infrared spectroscopic imaging protocols for high-troughput histopathology – volume: 1767 start-page: 1073 year: 2007 ident: 10.1038/labinvest.2012.101_bib34 article-title: Infrared spectroscopy of proteins publication-title: Biochim Biophys Acta doi: 10.1016/j.bbabio.2007.06.004 – year: 2010 ident: 10.1038/labinvest.2012.101_bib20 article-title: Toward automated breast histopathology using mid-IR spectroscopic imaging – start-page: 97 year: 2008 ident: 10.1038/labinvest.2012.101_bib49 article-title: Antemortem identification of transmissible spongiform encephalopathy (TSE) from serum by mid-infrared spectroscopy – year: 2008 ident: 10.1038/labinvest.2012.101_bib9 – year: 2012 ident: 10.1038/labinvest.2012.101_bib44 article-title: Dispersive line shape effects in infrared spectroscopy. publication-title: Analyst doi: 10.1039/c2an35582e – volume: 1688 start-page: 176 year: 2004 ident: 10.1038/labinvest.2012.101_bib55 article-title: Imaging of colorectal adenocarcinoma using FT-IR microspectroscopy and cluster analysis publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2003.12.006 – year: 2011 ident: 10.1038/labinvest.2012.101_bib31 – volume: 80 start-page: 8461 year: 2008 ident: 10.1038/labinvest.2012.101_bib16 article-title: IR spectral imaging for histopathological characterization of xenografted human colon carcinomas publication-title: Anal Chem doi: 10.1021/ac801191x – volume: 8315 start-page: 831504 year: 2012 ident: 10.1038/labinvest.2012.101_bib2 article-title: Automated detection of diagnostically relevant regions in H&E stained digital pathology slides publication-title: Proc SPIE ‘Medical Imaging 2012: Computer-Aided Diagnosis' – volume: 134 start-page: 51 year: 2005 ident: 10.1038/labinvest.2012.101_bib38 article-title: FTIR spectroscopic studies of lipid dynamics in phytosphingosine ceramide models of the stratum corneum lipid matrix publication-title: Chem Phy Lipids doi: 10.1016/j.chemphyslip.2004.12.002 – volume: 23 start-page: 469 year: 2005 ident: 10.1038/labinvest.2012.101_bib19 article-title: Infrared spectroscopic imaging for histopatholog recognition publication-title: Nat Biotech doi: 10.1038/nbt1080 – year: 2004 ident: 10.1038/labinvest.2012.101_bib45 – volume: 134 start-page: 1171 year: 2009 ident: 10.1038/labinvest.2012.101_bib53 article-title: Reflection contributions to the dispersion artefact in FTIR spectra of single biological cells publication-title: Analyst doi: 10.1039/b821349f – year: 2008 ident: 10.1038/labinvest.2012.101_bib56 article-title: Neuro-oncological applications of infrared and Raman spectroscopy – volume: 1758 start-page: 883 year: 2006 ident: 10.1038/labinvest.2012.101_bib21 article-title: Indentification of primary tumors of brain metastases by SIMCA classification of IR spectroscopic images publication-title: Biochem Biophys Acta doi: 10.1016/j.bbamem.2006.05.001 – volume: 135 start-page: 2815 year: 2010 ident: 10.1038/labinvest.2012.101_bib41 article-title: Accurate histopathology from low signal-to-noise ratio spectroscopic imaging data publication-title: Analyst doi: 10.1039/c0an00350f – volume: 72 start-page: 366 year: 2003 ident: 10.1038/labinvest.2012.101_bib48 article-title: Chemical heterogeneity in cell death: combined synchrotron IR and fluorescence microscopy studies of single apoptotic and necrotic cells publication-title: Biopolymers (Biospectroscopy) doi: 10.1002/bip.10435 – start-page: 1 year: 2008 ident: 10.1038/labinvest.2012.101_bib1 article-title: Introduction to spectral imaging, and applications to diagnosis of lymph nodes – volume: 93 start-page: 59 year: 2004 ident: 10.1038/labinvest.2012.101_bib15 article-title: FTIR mapping of the cervical transformation zone, squamous and glandular epithelium publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2003.12.028 – volume: 2 start-page: 37 year: 2009 ident: 10.1038/labinvest.2012.101_bib12 article-title: Spectral detection of micro-metastases in lymph node histopathology publication-title: J Biophotonics doi: 10.1002/jbio.200810066 – volume: 36 start-page: 1627 year: 1964 ident: 10.1038/labinvest.2012.101_bib42 article-title: Smoothing and differentiation of data by simplified least-squares procedures publication-title: Anal Chem doi: 10.1021/ac60214a047 – volume: 380 start-page: 931 year: 1999 ident: 10.1038/labinvest.2012.101_bib35 article-title: Molecular reaction mechanisms of proteins monitored by time-resolved FTIR spectroscopy publication-title: Biol Chem doi: 10.1515/BC.1999.115 – volume: 1758 start-page: 900 year: 2006 ident: 10.1038/labinvest.2012.101_bib23 article-title: A Fourier transform infrared microscopic image investigation into an animal model exhibiting glioblastoma multiforme publication-title: Biochem Biophys Acta doi: 10.1016/j.bbamem.2006.05.004 – volume: 34 start-page: 1805 year: 2010 ident: 10.1038/labinvest.2012.101_bib50 article-title: Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples publication-title: Am J Surg Path doi: 10.1097/PAS.0b013e3181f7dae3 – volume: 135 start-page: 268 year: 2010 ident: 10.1038/labinvest.2012.101_bib54 article-title: Resonant Mie Scattering (RMieS) correction of infrared spectra from highly scattering biological samples publication-title: Analyst doi: 10.1039/B921056C – volume: 90 start-page: 1068 year: 2010 ident: 10.1038/labinvest.2012.101_bib30 article-title: Spectral cytopathology of cervical samples: detecting cellular abnormalities in cytologically normal cells publication-title: Lab Invest doi: 10.1038/labinvest.2010.72 – volume: 93 start-page: 59 year: 2004 ident: 10.1038/labinvest.2012.101_bib46 article-title: Fourier transform infrared (FTIR) spectral mapping of the cervical transformation zone, and dysplastic squamous epithelium publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2003.12.028 – volume: 4 start-page: 55 year: 1998 ident: 10.1038/labinvest.2012.101_bib52 article-title: Infrared spectroscopy of human tissue. II. A comparative study of spectra of biopsies of cervical squamous epithelium and of exfoliated cervical cells publication-title: Biospectroscopy doi: 10.1002/(SICI)1520-6343(1998)4:1<55::AID-BSPY6>3.0.CO;2-R – volume: 44 start-page: 189 year: 1998 ident: 10.1038/labinvest.2012.101_bib18 article-title: FT-IR microspectroscopic imaging of human carcinoma in thin sections based on pattern recognition techniques publication-title: Cell Mol Biol – volume: 8 start-page: 1 year: 2008 ident: 10.1038/labinvest.2012.101_bib10 article-title: Infrared micro-spectral imaging: automatic distinction of tissuetypes in axillary lymph node histology' publication-title: BMC J Clin Pathol – volume: 39 start-page: 5439 year: 2011 ident: 10.1038/labinvest.2012.101_bib37 article-title: Monitoring the reversible B to A-like transition of DNA in eukaryotic cells using Fourier transform infrared spectroscopy publication-title: Nucleic Acids Res doi: 10.1093/nar/gkr175 – year: 1999 ident: 10.1038/labinvest.2012.101_bib40 – year: 1993 ident: 10.1038/labinvest.2012.101_bib33 – volume: 63 start-page: 307A year: 2009 ident: 10.1038/labinvest.2012.101_bib51 article-title: The infrared spectral signatures of disease: extracting the distinguishing spectral features between normal and diseased states publication-title: Appl Spectrosc doi: 10.1366/000370209789806894 – start-page: 121 year: 2008 ident: 10.1038/labinvest.2012.101_bib5 article-title: Vibrational microspectroscopy of cells and tissues – volume: 55 start-page: 955 year: 2001 ident: 10.1038/labinvest.2012.101_bib7 article-title: Near IR Raman spectroscopy for in vivo detection of cervical precancers publication-title: Appl Spectrosc doi: 10.1366/0003702011953018 – volume: 10 start-page: 135 year: 2011 ident: 10.1038/labinvest.2012.101_bib13 article-title: Spectral detection of micro-metastases and individual metastatic cells in lymph node histology publication-title: Tech Cancer Res Treatment doi: 10.7785/tcrt.2012.500188 – volume: 31 start-page: 426 year: 2001 ident: 10.1038/labinvest.2012.101_bib47 article-title: An efficient fuzzy classifier with feature selection based on fuzzy entropy publication-title: IEEE Trans Systems Man Cybernetics doi: 10.1109/3477.931536 – volume: 135 start-page: 3220 year: 2010 ident: 10.1038/labinvest.2012.101_bib57 article-title: A comparison of breast cancer tumor cells with varying expression of the Her2/neu receptor by Raman microspectroscopic imaging publication-title: Analyst doi: 10.1039/c0an00524j – volume: 135 start-page: 3042 year: 2010 ident: 10.1038/labinvest.2012.101_bib26 article-title: Raman spectroscopy - a new method for the intra-operative assessment of axillary lymph nodes publication-title: Analyst doi: 10.1039/c0an00527d – volume: 2 start-page: 91 year: 2009 ident: 10.1038/labinvest.2012.101_bib27 article-title: The potential for histological screening using a combination of rapid Raman mapping and principal component analysis publication-title: J Biophoton doi: 10.1002/jbio.200810070 – volume: 56 start-page: 1 year: 2002 ident: 10.1038/labinvest.2012.101_bib17 article-title: Characterization of colorectal adenocarcinoma sections by spatially resolved FT-IR microspectroscopy publication-title: Appl Spectrosc doi: 10.1366/0003702021954322 – volume: 1758 start-page: 892 year: 2006 ident: 10.1038/labinvest.2012.101_bib22 article-title: Brain tissue characterization by infrared imaging in a rat glioma model publication-title: Biochem Biophys Acta doi: 10.1016/j.bbamem.2006.05.003
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Snippet	We report results of a study utilizing a recently developed tissue diagnostic method, based on label-free spectral techniques, for the classification of lung...
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SubjectTerms	631/1647/1407/1555 631/1647/527/2257 692/699/67/1612 692/700/139 artificial neural network analysis Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology histopathology Humans immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Lung cancer Lung Neoplasms - classification Lung Neoplasms - diagnosis Medical sciences Medicine Medicine & Public Health Pathology Pneumology research-article spectral histopathology Spectrophotometry, Infrared - methods Tumors of the respiratory system and mediastinum
Title	Infrared spectral histopathology (SHP): a novel diagnostic tool for the accurate classification of lung cancer
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