Advancing glioblastoma treatment by targeting metabolism

Alterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand of tumor cells, including proliferation, growth, and survival. Many genes, proteins, and metabolites associated with GBM metabolism...

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Vydáno v:Neoplasia (New York, N.Y.) Ročník 51; s. 100985
Hlavní autoři: Zhao, Jinyi, Ma, Xuemei, Gao, Peixian, Han, Xueqi, Zhao, Pengxiang, Xie, Fei, Liu, Mengyu
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.05.2024
Neoplasia Press
Elsevier
Témata:
Brain Neoplasms - diagnosis
Brain Neoplasms - genetics
Brain Neoplasms - therapy
Cell Line, Tumor
Glioblastoma
Glioblastoma - genetics
Glioblastoma - metabolism
Glioblastoma - therapy
Humans
Metabolism
Review
Signaling pathway
Therapy
Therapy
Signaling pathway
Metabolism
Glioblastoma
ISSN:1476-5586, 1522-8002, 1476-5586
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Shrnutí:Alterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand of tumor cells, including proliferation, growth, and survival. Many genes, proteins, and metabolites associated with GBM metabolism reprogramming have been found to be aberrantly expressed, which may provide potential targets for cancer treatment. Therefore, it is becoming increasingly important to explore the role of internal and external factors in metabolic regulation in order to identify more precise therapeutic targets and diagnostic markers for GBM. In this review, we define the metabolic characteristics of GBM, investigate metabolic specificities such as targetable vulnerabilities and therapeutic resistance, as well as present current efforts to target GBM metabolism to improve the standard of care.
Bibliografie:ObjectType-Article-1
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ObjectType-Review-3
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ISSN:1476-5586
1522-8002
1476-5586
DOI:10.1016/j.neo.2024.100985