Genomic patterns resembling BRCA1- and BRCA2-mutated breast cancers predict benefit of intensified carboplatin-based chemotherapy

Introduction BRCA -mutated breast cancer cells lack the DNA-repair mechanism homologous recombination that is required for error-free DNA double-strand break (DSB) repair. Homologous recombination deficiency (HRD) may cause hypersensitivity to DNA DSB-inducing agents, such as bifunctional alkylating...

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Bibliographic Details
Published in:	Breast cancer research : BCR Vol. 16; no. 3; p. R47
Main Authors:	Vollebergh, Marieke A, Lips, Esther H, Nederlof, Petra M, Wessels, Lodewyk FA, Wesseling, Jelle, vd Vijver, Marc J, de Vries, Elisabeth GE, van Tinteren, Harm, Jonkers, Jos, Hauptmann, Michael, Rodenhuis, Sjoerd, Linn, Sabine C
Format:	Journal Article
Language:	English
Published:	London BioMed Central 15.05.2014 BioMed Central Ltd
Subjects:	Adult Analysis Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine BRCA1 Protein - genetics BRCA2 Protein - genetics Breast cancer Cancer Research Carboplatin - therapeutic use Care and treatment Comparative Genomic Hybridization Cyclophosphamide - therapeutic use DNA Breaks, Double-Stranded DNA Repair - genetics Epirubicin - therapeutic use Female Fluorouracil - therapeutic use Homologous Recombination - genetics Humans Middle Aged Oncology Patient outcomes Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Research Article Retrospective Studies Surgical Oncology Thiotepa - therapeutic use Treatment Outcome Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Breast Cancer Patient Sporadic Breast Cancer TP53 Mutation Array Comparative Genomic Hybridization Breast Cancer
ISSN:	1465-542X, 1465-5411, 1465-542X
Online Access:	Get full text
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