Epigenome-wide association studies identify DNA methylation associated with kidney function

Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study...

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Bibliographic Details
Published in:	Nature communications Vol. 8; no. 1; pp. 1286 - 12
Main Authors:	Chu, Audrey Y., Tin, Adrienne, Schlosser, Pascal, Ko, Yi-An, Qiu, Chengxiang, Yao, Chen, Joehanes, Roby, Grams, Morgan E., Liang, Liming, Gluck, Caroline A., Liu, Chunyu, Coresh, Josef, Hwang, Shih-Jen, Levy, Daniel, Boerwinkle, Eric, Pankow, James S., Yang, Qiong, Fornage, Myriam, Fox, Caroline S., Susztak, Katalin, Köttgen, Anna
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.11.2017 Nature Publishing Group Nature Portfolio
Subjects:	631/208/176/1988 692/4022/272 Aged Binding sites Binding Sites - genetics CCAAT-Enhancer-Binding Protein-beta - genetics CCAAT-Enhancer-Binding Protein-beta - metabolism CpG Islands Deoxyribonucleic acid Disease Progression DNA DNA methylation DNA Methylation - genetics E1A-Associated p300 Protein - genetics E1A-Associated p300 Protein - metabolism Enhancers Epidermal growth factor receptors Epigenesis, Genetic Epigenetics Female Fibrosis Genetic diversity Genetic Predisposition to Disease Genetic variance Genome-wide association studies Genome-Wide Association Study Genomes Genotype & phenotype Glomerular filtration rate Glomerular Filtration Rate - genetics Heart Humanities and Social Sciences Humans Kidney - metabolism Kidney diseases Kidney transplantation Kidneys Male Middle Aged multidisciplinary Prohibitins Prospective Studies Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Regulatory mechanisms (biology) Regulatory sequences Renal cortex Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - physiopathology Science Science (multidisciplinary) Studies Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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