Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

Targeting cereblon (CRBN) is currently one of the most frequently reported proteolysis‐targeting chimera (PROTAC) approaches, owing to favorable drug‐like properties of CRBN ligands, immunomodulatory imide drugs (IMiDs). However, IMiDs are known to be inherently unstable, readily undergoing hydrolys...

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Vydáno v:	Angewandte Chemie International Edition Ročník 60; číslo 51; s. 26663 - 26670
Hlavní autoři:	Min, Jaeki, Mayasundari, Anand, Keramatnia, Fatemeh, Jonchere, Barbara, Yang, Seung Wook, Jarusiewicz, Jamie, Actis, Marisa, Das, Sourav, Young, Brandon, Slavish, Jake, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H., Yun, Mi‐Kyung, Li, Zhenmei, Nithianantham, Stanley, Chai, Sergio, Chen, Taosheng, Shelat, Anang, Lee, Richard E., Nishiguchi, Gisele, White, Stephen W., Roussel, Martine F., Potts, Patrick Ryan, Fischer, Marcus, Rankovic, Zoran
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	WEINHEIM Wiley 13.12.2021 Wiley Subscription Services, Inc Wiley-VCH Verlag
Vydání:	International ed. in English
Témata:	Acute myeloid leukemia Adaptor Proteins, Signal Transducing - chemistry Binders Body fluids cereblon Chemistry Chemistry, Multidisciplinary Human health and pathology Humans Hydrolysis IMiD Immunomodulation Leukemia Life Sciences Ligands Myeloid leukemia phenyl glutarimide Physical Sciences Piperidones - chemistry PROTAC Proteolysis Science & Technology Ubiquitin-Protein Ligases - chemistry CC-90009 phenyl glutarimide COMPLEX PROTAC UBIQUITIN LIGASE HYDROLYSIS THALIDOMIDE GSPT1 cereblon METABOLISM DEGRADER PG E3 LIGASE MODULATOR TARGETED PROTEIN-DEGRADATION IMiD Ubiquitin-Protein Ligases Hydrolysis Signal Transducing Proteolysis Humans Piperidones Adaptor Proteins
ISSN:	1433-7851, 1521-3773, 1521-3773
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