Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

Targeting cereblon (CRBN) is currently one of the most frequently reported proteolysis‐targeting chimera (PROTAC) approaches, owing to favorable drug‐like properties of CRBN ligands, immunomodulatory imide drugs (IMiDs). However, IMiDs are known to be inherently unstable, readily undergoing hydrolys...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 60; no. 51; pp. 26663 - 26670
Main Authors:	Min, Jaeki, Mayasundari, Anand, Keramatnia, Fatemeh, Jonchere, Barbara, Yang, Seung Wook, Jarusiewicz, Jamie, Actis, Marisa, Das, Sourav, Young, Brandon, Slavish, Jake, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H., Yun, Mi‐Kyung, Li, Zhenmei, Nithianantham, Stanley, Chai, Sergio, Chen, Taosheng, Shelat, Anang, Lee, Richard E., Nishiguchi, Gisele, White, Stephen W., Roussel, Martine F., Potts, Patrick Ryan, Fischer, Marcus, Rankovic, Zoran
Format:	Journal Article
Language:	English
Published:	WEINHEIM Wiley 13.12.2021 Wiley Subscription Services, Inc Wiley-VCH Verlag
Edition:	International ed. in English
Subjects:	Acute myeloid leukemia Adaptor Proteins, Signal Transducing - chemistry Binders Body fluids cereblon Chemistry Chemistry, Multidisciplinary Human health and pathology Humans Hydrolysis IMiD Immunomodulation Leukemia Life Sciences Ligands Myeloid leukemia phenyl glutarimide Physical Sciences Piperidones - chemistry PROTAC Proteolysis Science & Technology Ubiquitin-Protein Ligases - chemistry CC-90009 phenyl glutarimide COMPLEX PROTAC UBIQUITIN LIGASE HYDROLYSIS THALIDOMIDE GSPT1 cereblon METABOLISM DEGRADER PG E3 LIGASE MODULATOR TARGETED PROTEIN-DEGRADATION IMiD Ubiquitin-Protein Ligases Hydrolysis Signal Transducing Proteolysis Humans Piperidones Adaptor Proteins
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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