Adipose Mesenchymal Stromal Cell‐Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose‐Escalation Trial

This phase I clinical trial evaluated the safety and clinical efficacy of adipose‐derived stromal cells (ASCs) in osteoarthritis. Eighteen patients with severe knee osteoarthritis were treated with a single intra‐articular injection of autologous ASCs at low (2 × 106 cells), medium (10 × 106), or hi...

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Bibliographic Details
Published in:	Stem cells translational medicine Vol. 5; no. 7; pp. 847 - 856
Main Authors:	Pers, Yves-Marie, Rackwitz, Lars, Ferreira, Rosanna, Pullig, Oliver, Delfour, Christophe, Barry, Frank, Sensebe, Luc, Casteilla, Louis, Fleury, Sandrine, Bourin, Philippe, Noël, Danièle, Canovas, François, Cyteval, Catherine, Lisignoli, Gina, Schrauth, Joachim, Haddad, Daniel, Domergue, Sophie, Noeth, Ulrich, Jorgensen, Christian
Format:	Journal Article
Language:	English
Published:	Durham, NC, USA AlphaMed Press 01.07.2016 Oxford University Press Wiley
Subjects:	Adipose mesenchymal stromal cells Adipose Tissue - cytology Adipose Tissue - transplantation Aged Arthritis Bone surgery Cell Count Clinical trials Female Flow cytometry Good Manufacturing Practice Human Clinical Humans Injections, Intra-Articular Intra‐articular injection Knee Life Sciences Male Mesenchymal Stem Cell Transplantation - adverse effects Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stem Cells / cytology Mesenchymal Stromal Cells - cytology Mesenchyme Middle Aged Osteoarthritis Osteoarthritis, Knee - pathology Osteoarthritis, Knee - therapy Phase I clinical trial Polymerase chain reaction Quality control Regenerative medicine Severity of Illness Index Stromal cells Therapeutic potential Treatment Outcome France Adipose mesenchymal stromal cells Intra-articular injection Regenerative medicine Therapeutic potential Osteoarthritis Phase I clinical trial
ISSN:	2157-6564, 2157-6580
Online Access:	Get full text
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