Immunocyte single cell analysis of vaccine‐induced narcolepsy

Increased incidence of narcolepsy type 1 (NT1) was observed following Pandemrix®‐vaccination, initiated as a preventive measure against the 2009 Influenza pandemic. Here, single cell analysis was conducted to suggest a lower number of CD8+CD27+ T cells among these patients. These findings provide un...

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Bibliographic Details
Published in:European journal of immunology Vol. 51; no. 1; pp. 247 - 249
Main Authors: Lind, Alexander, Salami, Falastin, Landtblom, Anne‐Marie, Palm, Lars, Lernmark, Åke, Adolfsson, Jörgen, Elding Larsson, Helena
Format: Journal Article
Language:English
Published: Germany Wiley Subscription Services, Inc 01.01.2021
Subjects:
Algorithms
Autoimmune diseases
Autoimmunity
Basic Medicine
Basophils - immunology
Case-Control Studies
CD27 antigen
CD8 antigen
CD8-Positive T-Lymphocytes - classification
CD8-Positive T-Lymphocytes - immunology
Flow Cytometry
HLA-DQ beta-Chains - immunology
Humans
Immunologi inom det medicinska området (Här ingår: Cell- och immunterapi)
Immunology in the Medical Area (including Cell and Immunotherapy)
Influenza
Influenza Vaccines - adverse effects
Influenza Vaccines - immunology
Lymphocytes T
Mass Cytometry
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Narcolepsy
Narcolepsy - etiology
Narcolepsy - immunology
Neurotrophin 1
Pandemics
Siblings
Single cell analysis
Sleep disorders
Vaccination
Vaccine
vaccine
mass cytometry
autoimmunity
narcolepsy
single cell analysis
ISSN:0014-2980, 1521-4141, 1521-4141
Online Access:Get full text
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Summary:Increased incidence of narcolepsy type 1 (NT1) was observed following Pandemrix®‐vaccination, initiated as a preventive measure against the 2009 Influenza pandemic. Here, single cell analysis was conducted to suggest a lower number of CD8+CD27+ T cells among these patients. These findings provide understanding into the autoimmune pathogenesis of NT1.
Bibliography:https://publons.com/publon/10.1002/eji.202048633
The peer review history for this article is available at
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ISSN:0014-2980
1521-4141
1521-4141
DOI:10.1002/eji.202048633