Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG

Abstract LH and chorionic gonadotropin (CG) are glycoproteins fundamental to sexual development and reproduction. Because they act on the same receptor (LHCGR), the general consensus has been that LH and human CG (hCG) are equivalent. However, separate evolution of LHβ and hCGβ subunits occurred in...

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Bibliographic Details
Published in:	Endocrine reviews Vol. 39; no. 5; pp. 549 - 592
Main Authors:	Casarini, Livio, Santi, Daniele, Brigante, Giulia, Simoni, Manuela
Format:	Journal Article
Language:	English
Published:	Washington, DC Endocrine Society 01.10.2018 Copyright Oxford University Press Oxford University Press
Subjects:	AKT protein Androgens Angiogenesis Animals Apoptosis Biochemistry Biological Evolution Chorionic gonadotropin Chorionic Gonadotropin - metabolism Chorionic gonadotropins Cyclic AMP Displays (Marketing) Equivalence Estrogens Evolution Female Gametocytes Gametogenesis Glycoproteins Glycosylation Gonadotropins Gonads Half-life Hormones Humans Intracellular signalling Isoforms Kinases Luteinizing hormone Luteinizing Hormone - metabolism Oocytes Phenols (Class of compounds) Pituitary Pituitary (anterior) Pituitary hormones Placental hormones Pregnancy Primates Progesterone Protein kinase A Protein kinases Proteins Receptors, LH - metabolism Reproduction Reproduction (biology) Sex hormones Signal Transduction - physiology Testosterone
ISSN:	0163-769X, 1945-7189, 1945-7189
Online Access:	Get full text
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