Lipid levels and the risk of hemorrhagic stroke among women

To examine the association between lipid levels and hemorrhagic stroke risk among women. We performed a prospective cohort study among 27,937 women enrolled in the Women's Health Study with measured total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cho...

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Veröffentlicht in:Neurology Jg. 92; H. 19; S. e2286
Hauptverfasser: Rist, Pamela M, Buring, Julie E, Ridker, Paul M, Kase, Carlos S, Kurth, Tobias, Rexrode, Kathryn M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 07.05.2019
Schlagworte:
Aged
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Female
Follow-Up Studies
Health Surveys
Humans
Incidence
Intracranial Hemorrhages - blood
Intracranial Hemorrhages - epidemiology
Middle Aged
Prospective Studies
Risk
Stroke - blood
Stroke - epidemiology
Triglycerides - blood
ISSN:1526-632X, 1526-632X
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Zusammenfassung:To examine the association between lipid levels and hemorrhagic stroke risk among women. We performed a prospective cohort study among 27,937 women enrolled in the Women's Health Study with measured total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), as well as triglycerides. Strokes were confirmed by medical record review. We used Cox proportional hazards models to analyze associations between lipid categories and hemorrhagic stroke risk. During a mean of 19.3 years of follow-up, 137 hemorrhagic strokes occurred. Compared to those with LDL-C levels 100-129.9 mg/dL, after multivariable adjustment, those with LDL-C levels <70 mg/dL had 2.17 times the risk (95% confidence interval [CI] 1.05, 4.48) of experiencing a hemorrhagic stroke. No significant increase in risk was seen for those with LDL-C levels 130-159.9 mg/dL (relative risk [RR] 1.14; 95% CI 0.72, 1.80) or 70-99.9 mg/dL (RR 1.25; 95% CI 0.76, 2.04). There was a suggestion, although not significant, of increased risk for those with LDL-C levels ≥160 mg/dL (RR 1.53; 95% CI 0.92, 2.52). Women in the lowest quartile of triglycerides had a significantly increased risk of hemorrhagic stroke compared to women in the top quartile after multivariable adjustment (RR 2.00; 95% CI 1.18, 3.39). We observed no significant associations between total cholesterol or HDL-C levels and hemorrhagic stroke risk. LDL-C levels <70 mg/dL and low triglyceride levels were associated with increased risk of hemorrhagic stroke among women.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1526-632X
1526-632X
DOI:10.1212/WNL.0000000000007454