Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

Histone deacetylases (HDACs) regulate inflammatory gene expression, as indicated by the potent antiinflammatory activity of pan-HDAC inhibitors. However, the specific contribution of each of the 11 HDAC proteins to the inflammatory gene expression program is unknown. Using an integrated genomic appr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 109; H. 42; S. E2865
Hauptverfasser:	Chen, Xuefen, Barozzi, Iros, Termanini, Alberto, Prosperini, Elena, Recchiuti, Antonio, Dalli, Jesmond, Mietton, Flore, Matteoli, Gianluca, Hiebert, Scott, Natoli, Gioacchino
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 16.10.2012
Schlagworte:	Animals Base Sequence Chromatin Immunoprecipitation Cyclooxygenase 1 - metabolism Cytokines - analysis DNA Primers - genetics Enzyme-Linked Immunosorbent Assay Flow Cytometry Gene Expression Regulation - genetics Genomics Histone Deacetylases - deficiency Histone Deacetylases - metabolism Macrophages - metabolism Membrane Proteins - metabolism Mice Mice, Transgenic Molecular Sequence Data Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	Histone deacetylases (HDACs) regulate inflammatory gene expression, as indicated by the potent antiinflammatory activity of pan-HDAC inhibitors. However, the specific contribution of each of the 11 HDAC proteins to the inflammatory gene expression program is unknown. Using an integrated genomic approach, we found that Hdac3-deficient macrophages were unable to activate almost half of the inflammatory gene expression program when stimulated with LPS. A large part of the activation defect was attributable to loss of basal and LPS-inducible expression of IFN-β, which maintains Stat1 protein levels in unstimulated cells and acts in an autocrine/paracrine manner after stimulation to promote a secondary wave of Stat1-dependent gene expression. Loss of Hdac3-mediated repression of nuclear receptors led to hyperacetylation of thousands of genomic sites and associated gene derepression. The up-regulation of the constitutively expressed prostaglandin endoperoxide synthase, Ptgs1 (Cox-1), a nuclear receptor target, had a causative role in the phenotype because its chemical inhibition reverted, albeit partially, the Ifn-β activation defect. These data indicate a central role for Hdac3 in inflammation and may have relevance for the use of selective Hdac inhibitors as antiinflammatory agents.
AbstractList	Histone deacetylases (HDACs) regulate inflammatory gene expression, as indicated by the potent antiinflammatory activity of pan-HDAC inhibitors. However, the specific contribution of each of the 11 HDAC proteins to the inflammatory gene expression program is unknown. Using an integrated genomic approach, we found that Hdac3-deficient macrophages were unable to activate almost half of the inflammatory gene expression program when stimulated with LPS. A large part of the activation defect was attributable to loss of basal and LPS-inducible expression of IFN-β, which maintains Stat1 protein levels in unstimulated cells and acts in an autocrine/paracrine manner after stimulation to promote a secondary wave of Stat1-dependent gene expression. Loss of Hdac3-mediated repression of nuclear receptors led to hyperacetylation of thousands of genomic sites and associated gene derepression. The up-regulation of the constitutively expressed prostaglandin endoperoxide synthase, Ptgs1 (Cox-1), a nuclear receptor target, had a causative role in the phenotype because its chemical inhibition reverted, albeit partially, the Ifn-β activation defect. These data indicate a central role for Hdac3 in inflammation and may have relevance for the use of selective Hdac inhibitors as antiinflammatory agents. Histone deacetylases (HDACs) regulate inflammatory gene expression, as indicated by the potent antiinflammatory activity of pan-HDAC inhibitors. However, the specific contribution of each of the 11 HDAC proteins to the inflammatory gene expression program is unknown. Using an integrated genomic approach, we found that Hdac3-deficient macrophages were unable to activate almost half of the inflammatory gene expression program when stimulated with LPS. A large part of the activation defect was attributable to loss of basal and LPS-inducible expression of IFN-β, which maintains Stat1 protein levels in unstimulated cells and acts in an autocrine/paracrine manner after stimulation to promote a secondary wave of Stat1-dependent gene expression. Loss of Hdac3-mediated repression of nuclear receptors led to hyperacetylation of thousands of genomic sites and associated gene derepression. The up-regulation of the constitutively expressed prostaglandin endoperoxide synthase, Ptgs1 (Cox-1), a nuclear receptor target, had a causative role in the phenotype because its chemical inhibition reverted, albeit partially, the Ifn-β activation defect. These data indicate a central role for Hdac3 in inflammation and may have relevance for the use of selective Hdac inhibitors as antiinflammatory agents.Histone deacetylases (HDACs) regulate inflammatory gene expression, as indicated by the potent antiinflammatory activity of pan-HDAC inhibitors. However, the specific contribution of each of the 11 HDAC proteins to the inflammatory gene expression program is unknown. Using an integrated genomic approach, we found that Hdac3-deficient macrophages were unable to activate almost half of the inflammatory gene expression program when stimulated with LPS. A large part of the activation defect was attributable to loss of basal and LPS-inducible expression of IFN-β, which maintains Stat1 protein levels in unstimulated cells and acts in an autocrine/paracrine manner after stimulation to promote a secondary wave of Stat1-dependent gene expression. Loss of Hdac3-mediated repression of nuclear receptors led to hyperacetylation of thousands of genomic sites and associated gene derepression. The up-regulation of the constitutively expressed prostaglandin endoperoxide synthase, Ptgs1 (Cox-1), a nuclear receptor target, had a causative role in the phenotype because its chemical inhibition reverted, albeit partially, the Ifn-β activation defect. These data indicate a central role for Hdac3 in inflammation and may have relevance for the use of selective Hdac inhibitors as antiinflammatory agents.
Author	Barozzi, Iros Dalli, Jesmond Recchiuti, Antonio Chen, Xuefen Termanini, Alberto Hiebert, Scott Mietton, Flore Matteoli, Gianluca Prosperini, Elena Natoli, Gioacchino
Author_xml	– sequence: 1 givenname: Xuefen surname: Chen fullname: Chen, Xuefen organization: Italian Institute of Technology at European School of Molecular Medicine, 20139 Milan, Italy – sequence: 2 givenname: Iros surname: Barozzi fullname: Barozzi, Iros – sequence: 3 givenname: Alberto surname: Termanini fullname: Termanini, Alberto – sequence: 4 givenname: Elena surname: Prosperini fullname: Prosperini, Elena – sequence: 5 givenname: Antonio surname: Recchiuti fullname: Recchiuti, Antonio – sequence: 6 givenname: Jesmond surname: Dalli fullname: Dalli, Jesmond – sequence: 7 givenname: Flore surname: Mietton fullname: Mietton, Flore – sequence: 8 givenname: Gianluca surname: Matteoli fullname: Matteoli, Gianluca – sequence: 9 givenname: Scott surname: Hiebert fullname: Hiebert, Scott – sequence: 10 givenname: Gioacchino surname: Natoli fullname: Natoli, Gioacchino
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22802645$$D View this record in MEDLINE/PubMed
BookMark	eNpN0E1LxDAQBuAgK-6Hnr1Jjl66ZtKmbY6yqCssCKLnMmknu5Wm7SYtuP_egh94mZnDw8zwLtms7Vpi7BrEGkQW3_UthjWABIgBhD5ji6lClCZazP7Nc7YM4UMIoVUuLthcylzINFELVr_Scaw9OWoHbjvPhwPxQx2G6Q6vCEsaTg0G4tsKy_hP1K1t0DkcOn_ie5osffaeQqi7lve-23t0E-IOS9_1B9xTuGTnFptAVz99xd4fH94222j38vS8ud9FpUqzIbKUUEaptaCE0ZhWWijQBIkRtsqV0Yay0sakEhtrneWYg60MGJEradGgXLHb773TG8eRwlC4OpTUNNhSN4YCpqwkJFksJnrzQ0fjqCp6Xzv0p-I3HvkFP55rsg
CitedBy_id	crossref_primary_10_3389_fmolb_2023_1190094 crossref_primary_10_3389_fimmu_2022_841716 crossref_primary_10_1186_s13148_025_01865_5 crossref_primary_10_3390_ph7060634 crossref_primary_10_1097_MOL_0000000000000109 crossref_primary_10_1124_jpet_114_217315 crossref_primary_10_1517_13543784_2016_1146251 crossref_primary_10_1073_pnas_2016049117 crossref_primary_10_1210_en_2017_03000 crossref_primary_10_1016_j_bbalip_2021_159019 crossref_primary_10_1155_2016_6591703 crossref_primary_10_1080_14756366_2018_1437156 crossref_primary_10_15252_emmm_201404170 crossref_primary_10_1038_s41419_023_06147_7 crossref_primary_10_1158_0008_5472_CAN_22_1270 crossref_primary_10_1371_journal_pone_0208755 crossref_primary_10_1038_ni_3713 crossref_primary_10_1080_17501911_2024_2419357 crossref_primary_10_1161_ATVBAHA_115_305046 crossref_primary_10_1016_j_tins_2025_06_002 crossref_primary_10_1089_ars_2016_6695 crossref_primary_10_3389_fcvm_2022_1077290 crossref_primary_10_1074_jbc_RA119_010707 crossref_primary_10_3389_fimmu_2018_01977 crossref_primary_10_3389_fimmu_2021_669566 crossref_primary_10_1038_s41580_018_0076_0 crossref_primary_10_1016_j_jaut_2015_09_003 crossref_primary_10_7554_eLife_104367 crossref_primary_10_1016_j_lfs_2019_02_004 crossref_primary_10_1186_s12974_024_03159_8 crossref_primary_10_1016_j_imlet_2020_07_007 crossref_primary_10_1093_ehjopen_oeab022 crossref_primary_10_1007_s11904_023_00675_9 crossref_primary_10_1016_j_lfs_2023_121574 crossref_primary_10_1155_2018_7313515 crossref_primary_10_1016_j_coph_2013_06_002 crossref_primary_10_1016_j_csbj_2023_03_050 crossref_primary_10_1016_j_molcel_2020_08_015 crossref_primary_10_3892_mmr_2024_13367 crossref_primary_10_1038_s41420_023_01399_w crossref_primary_10_1089_ars_2014_5915 crossref_primary_10_1002_pmic_201400075 crossref_primary_10_1186_s12974_021_02273_1 crossref_primary_10_1016_j_intimp_2019_106086 crossref_primary_10_1016_j_smim_2015_10_003 crossref_primary_10_3390_v11060555 crossref_primary_10_3389_fimmu_2024_1392145 crossref_primary_10_2492_inflammregen_35_129 crossref_primary_10_1016_j_intimp_2021_107791 crossref_primary_10_1093_nar_gkaf880 crossref_primary_10_1002_glia_23887 crossref_primary_10_1016_j_pathol_2021_09_001 crossref_primary_10_1164_rccm_201211_2025ED crossref_primary_10_1016_j_trsl_2017_09_002 crossref_primary_10_1186_s13075_024_03335_4 crossref_primary_10_1016_j_ejmech_2019_05_038 crossref_primary_10_4049_jimmunol_1700223 crossref_primary_10_1128_spectrum_00737_24 crossref_primary_10_1186_s13395_021_00273_6 crossref_primary_10_1096_fj_201900394RRR crossref_primary_10_1172_JCI162190 crossref_primary_10_1093_nar_gkaa088 crossref_primary_10_1007_s00109_021_02141_8 crossref_primary_10_1016_j_it_2012_11_001 crossref_primary_10_1007_s11033_025_10872_x crossref_primary_10_1016_j_molcel_2022_11_016 crossref_primary_10_3389_fgene_2019_00640 crossref_primary_10_3389_fimmu_2025_1614879 crossref_primary_10_1016_j_rbmo_2023_103288 crossref_primary_10_3389_fcvm_2022_868788 crossref_primary_10_7554_eLife_80477 crossref_primary_10_1016_j_ejmech_2018_10_072 crossref_primary_10_3390_cancers12061411 crossref_primary_10_3390_ijms23179752 crossref_primary_10_1016_j_molmed_2024_01_007 crossref_primary_10_1111_apt_13008 crossref_primary_10_3389_fcell_2022_931493 crossref_primary_10_1038_s41590_018_0184_1 crossref_primary_10_1038_nature15252 crossref_primary_10_1371_journal_pone_0152498 crossref_primary_10_1371_journal_ppat_1004785 crossref_primary_10_1016_j_jmb_2014_08_015 crossref_primary_10_3389_fimmu_2022_845678 crossref_primary_10_1186_s13098_025_01880_9 crossref_primary_10_1016_j_immuni_2018_12_018 crossref_primary_10_1038_cti_2015_46 crossref_primary_10_1096_fj_13_248393 crossref_primary_10_1038_s41418_020_00631_9 crossref_primary_10_1038_nm_4114 crossref_primary_10_1016_j_coph_2017_04_008 crossref_primary_10_1172_JCI69738 crossref_primary_10_1016_j_it_2014_09_007 crossref_primary_10_1371_journal_pone_0121748 crossref_primary_10_1016_j_addr_2022_114298 crossref_primary_10_1091_mbc_e15_04_0209 crossref_primary_10_2217_epi_15_71 crossref_primary_10_1016_j_ejphar_2018_05_003 crossref_primary_10_1016_j_cbpa_2016_06_019 crossref_primary_10_1111_andr_13231 crossref_primary_10_1186_s13148_021_01046_0 crossref_primary_10_1038_s41598_017_08535_4 crossref_primary_10_1161_ATVBAHA_114_303393 crossref_primary_10_1074_jbc_R116_774745 crossref_primary_10_1371_journal_pbio_3000941 crossref_primary_10_3390_v10100525 crossref_primary_10_1016_j_phrs_2021_105969 crossref_primary_10_3389_fphys_2019_01060 crossref_primary_10_1186_s12943_023_01725_x crossref_primary_10_1002_mnfr_201400307 crossref_primary_10_1080_02648725_2021_1989847 crossref_primary_10_1016_j_apsb_2025_08_022 crossref_primary_10_3390_ijms20194964 crossref_primary_10_1038_s42003_025_08290_7 crossref_primary_10_1016_j_cbpa_2014_08_013 crossref_primary_10_1016_j_cellsig_2021_110099 crossref_primary_10_3390_ijms24097876 crossref_primary_10_1038_nrrheum_2013_17 crossref_primary_10_3389_fimmu_2024_1419685 crossref_primary_10_1136_annrheumdis_2015_209064 crossref_primary_10_1002_iub_2402 crossref_primary_10_3390_ijms18010137 crossref_primary_10_1074_jbc_M113_496281 crossref_primary_10_1186_s13059_018_1524_z crossref_primary_10_1136_annrheumdis_2014_205635 crossref_primary_10_1038_pr_2013_238 crossref_primary_10_1007_s10787_012_0166_0 crossref_primary_10_1016_j_intimp_2020_107340 crossref_primary_10_1016_j_autrev_2024_103733 crossref_primary_10_1073_pnas_1816399116 crossref_primary_10_3389_fphar_2023_1125866 crossref_primary_10_3389_fimmu_2020_550769 crossref_primary_10_1016_j_jnutbio_2018_03_002 crossref_primary_10_1016_j_bbadis_2013_09_014 crossref_primary_10_3390_pathophysiology29030038 crossref_primary_10_1038_s41467_021_25393_x crossref_primary_10_3389_fimmu_2015_00661 crossref_primary_10_1089_jmf_2015_0156 crossref_primary_10_1186_s12931_024_02769_3 crossref_primary_10_3389_fimmu_2021_688910 crossref_primary_10_1155_2017_6237351 crossref_primary_10_1038_srep45047 crossref_primary_10_1089_jmf_2018_4253 crossref_primary_10_1242_dev_201548 crossref_primary_10_1007_s00281_019_00748_1 crossref_primary_10_1016_j_ejmech_2023_116037 crossref_primary_10_1007_s00011_022_01651_6 crossref_primary_10_1084_jem_20220666 crossref_primary_10_1002_acn3_47 crossref_primary_10_1016_j_atherosclerosis_2014_12_048 crossref_primary_10_1038_s41419_023_05656_9 crossref_primary_10_1111_jcmm_16616 crossref_primary_10_4049_jimmunol_1400486 crossref_primary_10_1371_journal_ppat_1005938 crossref_primary_10_1038_s41563_018_0225_z crossref_primary_10_1002_adbi_202300211 crossref_primary_10_1038_s41563_018_0190_6 crossref_primary_10_3390_ijms20122949 crossref_primary_10_1038_icb_2013_56 crossref_primary_10_1007_s12975_020_00783_3 crossref_primary_10_1093_nutrit_nux001 crossref_primary_10_1177_0022034519885088 crossref_primary_10_3389_fonc_2014_00111 crossref_primary_10_1177_0192623314553805 crossref_primary_10_1002_cbin_11952 crossref_primary_10_3390_epigenomes3030019 crossref_primary_10_1111_imcb_12455 crossref_primary_10_3389_fcell_2020_576946 crossref_primary_10_1016_j_cca_2025_120455 crossref_primary_10_1016_j_neuropharm_2025_110678 crossref_primary_10_1016_j_fsi_2023_109214 crossref_primary_10_1016_j_ejphar_2015_03_101 crossref_primary_10_1038_nature12687 crossref_primary_10_3390_cells11244072 crossref_primary_10_3390_cells10112962 crossref_primary_10_1002_1873_3468_12850 crossref_primary_10_1371_journal_pone_0132984 crossref_primary_10_1038_s41598_020_78364_5 crossref_primary_10_1089_jir_2016_0004 crossref_primary_10_3390_nu8060381 crossref_primary_10_3390_ijms20020346 crossref_primary_10_1371_journal_pntd_0005137 crossref_primary_10_3390_cancers14061469 crossref_primary_10_1177_0192623314553475 crossref_primary_10_1016_j_ejmech_2020_112171 crossref_primary_10_1016_j_neures_2021_05_014 crossref_primary_10_1002_jsfa_10734 crossref_primary_10_1016_j_biopha_2022_114052 crossref_primary_10_1371_journal_pone_0183679 crossref_primary_10_1016_j_pharmthera_2016_07_013 crossref_primary_10_1128_microbiolspec_MCHD_0010_2015 crossref_primary_10_1007_s12015_024_10759_7 crossref_primary_10_1111_jcmm_12595 crossref_primary_10_3389_fimmu_2021_652160 crossref_primary_10_1038_nri3777 crossref_primary_10_1016_j_bcp_2016_03_010 crossref_primary_10_1039_C8FO02438C crossref_primary_10_1074_jbc_M117_804328 crossref_primary_10_1016_j_cellsig_2020_109553 crossref_primary_10_1126_sciimmunol_aah4609 crossref_primary_10_1007_s12035_022_03083_z crossref_primary_10_1042_BCJ20240380 crossref_primary_10_1063_5_0087699 crossref_primary_10_1093_burnst_tkac057 crossref_primary_10_3109_08916934_2015_1134510 crossref_primary_10_1186_s12974_019_1495_3 crossref_primary_10_1016_j_biopha_2023_115309 crossref_primary_10_1016_j_compbiolchem_2025_108499 crossref_primary_10_1084_jem_20151764 crossref_primary_10_3390_cancers13071665 crossref_primary_10_1007_s40472_016_0130_9 crossref_primary_10_1093_intimm_dxy042 crossref_primary_10_1096_fj_202301762RR crossref_primary_10_3390_nu12123657 crossref_primary_10_1002_jcla_24699 crossref_primary_10_18632_oncotarget_17586 crossref_primary_10_3389_fnsys_2019_00037 crossref_primary_10_1002_jcp_26497 crossref_primary_10_1038_s41419_019_2212_y crossref_primary_10_1016_j_tem_2012_09_003 crossref_primary_10_3389_fimmu_2020_00036 crossref_primary_10_1002_ange_202310059 crossref_primary_10_1371_journal_pone_0068669 crossref_primary_10_1016_j_jtcme_2021_04_004 crossref_primary_10_1007_s00408_025_00798_3 crossref_primary_10_2217_epi_2016_0136 crossref_primary_10_1016_j_cyto_2022_155842 crossref_primary_10_1016_j_jff_2020_104309 crossref_primary_10_1016_j_banm_2023_01_023 crossref_primary_10_1371_journal_pone_0208602 crossref_primary_10_1073_pnas_2316104121 crossref_primary_10_1080_15592294_2023_2241008 crossref_primary_10_7554_eLife_104367_3 crossref_primary_10_1007_s10753_013_9686_z crossref_primary_10_1016_j_taap_2021_115795 crossref_primary_10_1089_ars_2013_5750 crossref_primary_10_1002_anie_202310059 crossref_primary_10_1016_j_intimp_2025_115012 crossref_primary_10_3389_fimmu_2023_1267550 crossref_primary_10_3390_pharmaceutics15122659 crossref_primary_10_1155_2018_8917804 crossref_primary_10_3389_fimmu_2023_1190333 crossref_primary_10_1073_pnas_1613156113 crossref_primary_10_1007_s10787_019_00663_9 crossref_primary_10_1172_JCI77088 crossref_primary_10_3389_fendo_2020_00062 crossref_primary_10_1016_j_it_2018_11_006 crossref_primary_10_3390_cancers14051221 crossref_primary_10_1038_nri3581 crossref_primary_10_1038_s41598_022_05698_7 crossref_primary_10_3390_ijms23137300 crossref_primary_10_1038_s41419_017_0174_5 crossref_primary_10_1186_s12974_022_02563_2 crossref_primary_10_2217_epi_2020_0380 crossref_primary_10_1016_j_bbadis_2020_165903 crossref_primary_10_1016_j_jaci_2023_04_022 crossref_primary_10_3389_fimmu_2024_1450440 crossref_primary_10_1007_s00101_014_2402_z crossref_primary_10_1016_j_tem_2016_06_008 crossref_primary_10_3389_fimmu_2024_1415597 crossref_primary_10_1016_j_coi_2022_102173 crossref_primary_10_3389_fmed_2022_1072453 crossref_primary_10_3390_biomedicines13040853
ContentType	Journal Article
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1073/pnas.1121131109
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Sciences (General)
EISSN	1091-6490
ExternalDocumentID	22802645
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NCI NIH HHS grantid: R01 CA164605 – fundername: NIGMS NIH HHS grantid: R01 GM095967 – fundername: NIGMS NIH HHS grantid: 5P01GM095967
GroupedDBID	--- -DZ -~X .55 0R~ 123 29P 2AX 2FS 2WC 4.4 53G 5RE 5VS 85S AACGO AAFWJ AANCE ABBHK ABOCM ABPLY ABPPZ ABTLG ABXSQ ABZEH ACGOD ACHIC ACIWK ACNCT ACPRK ADULT AENEX AEUPB AEXZC AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AQVQM BKOMP CGR CS3 CUY CVF D0L DCCCD DIK DOOOF DU5 E3Z EBS ECM EIF EJD F5P FRP GX1 H13 HH5 HTVGU HYE IPSME JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST KQ8 L7B LU7 MVM N9A NPM N~3 O9- OK1 P-O PNE PQQKQ R.V RHF RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR VQA VXZ W8F WH7 WOQ WOW X7M XSW Y6R YBH YIF YIN YKV YSK ZCA ~02 ~KM 7X8 ADQXQ ADXHL
ID	FETCH-LOGICAL-c567t-fe4e7e6ff150b9a6d90519e14b0fd85b9be7cf3e54f39978a81fdb1b0852faba2
IEDL.DBID	7X8
ISICitedReferencesCount	317
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000310515800006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1091-6490
IngestDate	Fri Sep 05 06:12:26 EDT 2025 Wed Feb 19 01:52:23 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	42
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c567t-fe4e7e6ff150b9a6d90519e14b0fd85b9be7cf3e54f39978a81fdb1b0852faba2
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://www.pnas.org/content/pnas/109/42/E2865.full.pdf
PMID	22802645
PQID	1113214730
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_1113214730 pubmed_primary_22802645
PublicationCentury	2000
PublicationDate	2012-10-16
PublicationDateYYYYMMDD	2012-10-16
PublicationDate_xml	– month: 10 year: 2012 text: 2012-10-16 day: 16
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Proceedings of the National Academy of Sciences - PNAS
PublicationTitleAlternate	Proc Natl Acad Sci U S A
PublicationYear	2012
References	15452344 - Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14461-6 20206554 - Immunity. 2010 Mar 26;32(3):317-28 15708534 - Drug Discov Today. 2005 Feb 1;10(3):197-204 18406327 - Mol Cell. 2008 Apr 11;30(1):61-72 9422508 - Nature. 1998 Jan 1;391(6662):79-82 19729616 - Science. 2009 Oct 9;326(5950):257-63 20141834 - Cell. 2010 Jan 22;140(2):197-208 12354379 - Immunity. 2002 Sep;17(3):251-63 20084085 - Nat Rev Genet. 2010 Feb;11(2):109-23 19379692 - Cell. 2009 Apr 17;137(2):259-72 10860984 - Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7202-7 19182219 - J Biol Chem. 2009 May 15;284(20):13291-5 20100935 - J Immunol. 2010 Mar 1;184(5):2718-28 22025054 - Nat Rev Immunol. 2011 Nov;11(11):750-61 11867742 - Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2995-3000 21343618 - Sci Signal. 2011;4(161):ra11 18443042 - Mol Cell Biol. 2008 Jul;28(13):4407-23 21068722 - Nature. 2010 Dec 23;468(7327):1119-23 21258344 - Nat Biotechnol. 2011 Mar;29(3):255-65 19779457 - EMBO J. 2009 Nov 4;28(21):3341-52 10638762 - Nature. 2000 Jan 6;403(6765):103-8 20436908 - PLoS Biol. 2010;8(4):e1000361 12855817 - Science. 2003 Aug 1;301(5633):640-3 19105661 - Annu Rev Immunol. 2009;27:451-83 9737710 - FASEB J. 1998 Sep;12(12):1063-73 18250418 - J Immunol. 2008 Feb 15;180(4):2125-31 18568166 - Chem Soc Rev. 2008 Jul;37(7):1402-13 21339212 - Ann Rheum Dis. 2011 Mar;70 Suppl 1:i109-12 12434058 - Science. 2002 Nov 15;298(5597):1412-4 11711434 - Genes Dev. 2001 Nov 15;15(22):2991-3004 16397526 - Nat Rev Cancer. 2006 Jan;6(1):38-51 18292778 - Nat Rev Mol Cell Biol. 2008 Mar;9(3):206-18 14980219 - Cell. 2004 Feb 20;116(4):511-26 20436486 - Nat Chem Biol. 2010 Jun;6(6):433-41 20832726 - Mol Cell. 2010 Sep 10;39(5):750-60 16200064 - Nat Genet. 2005 Nov;37(11):1289-95 19859064 - Nat Rev Immunol. 2009 Oct;9(10):692-703 20566897 - Blood. 2010 Oct 14;116(15):2732-41 21551061 - Science. 2011 May 6;332(6030):717-21 7566114 - Nature. 1995 Oct 5;377(6548):397-404 20303874 - Cell. 2010 Mar 19;140(6):833-44 15616592 - EMBO J. 2005 Jan 12;24(1):85-96 19596240 - Cell. 2009 Jul 10;138(1):129-45 7566127 - Nature. 1995 Oct 5;377(6548):454-7 22048801 - Curr Protoc Immunol. 2011 Nov;Chapter 14:Unit 14.26 21570914 - Trends Immunol. 2011 Jul;32(7):335-43 18599619 - Mol Endocrinol. 2008 Sep;22(9):2076-84 22156208 - Genes Dev. 2011 Dec 1;25(23):2480-8 17329241 - J Biol Chem. 2007 Apr 20;282(16):11613-7 17277777 - Nat Genet. 2007 Mar;39(3):311-8 19596239 - Cell. 2009 Jul 10;138(1):114-28 20513432 - Mol Cell. 2010 May 28;38(4):576-89 10781090 - Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4844-9 21978789 - Biol Direct. 2011;6:51 17825402 - Cell. 2007 Sep 21;130(6):1083-94 19608861 - Science. 2009 Aug 14;325(5942):834-40 21245163 - Genes Dev. 2011 Jan 15;25(2):101-6 10365964 - Nature. 1999 Jun 3;399(6735):491-6
References_xml	– reference: 20084085 - Nat Rev Genet. 2010 Feb;11(2):109-23 – reference: 10860984 - Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7202-7 – reference: 19729616 - Science. 2009 Oct 9;326(5950):257-63 – reference: 21245163 - Genes Dev. 2011 Jan 15;25(2):101-6 – reference: 10365964 - Nature. 1999 Jun 3;399(6735):491-6 – reference: 10638762 - Nature. 2000 Jan 6;403(6765):103-8 – reference: 22025054 - Nat Rev Immunol. 2011 Nov;11(11):750-61 – reference: 19379692 - Cell. 2009 Apr 17;137(2):259-72 – reference: 7566127 - Nature. 1995 Oct 5;377(6548):454-7 – reference: 19182219 - J Biol Chem. 2009 May 15;284(20):13291-5 – reference: 12855817 - Science. 2003 Aug 1;301(5633):640-3 – reference: 18406327 - Mol Cell. 2008 Apr 11;30(1):61-72 – reference: 21978789 - Biol Direct. 2011;6:51 – reference: 19105661 - Annu Rev Immunol. 2009;27:451-83 – reference: 11867742 - Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2995-3000 – reference: 9737710 - FASEB J. 1998 Sep;12(12):1063-73 – reference: 15616592 - EMBO J. 2005 Jan 12;24(1):85-96 – reference: 19596239 - Cell. 2009 Jul 10;138(1):114-28 – reference: 15452344 - Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14461-6 – reference: 19608861 - Science. 2009 Aug 14;325(5942):834-40 – reference: 18568166 - Chem Soc Rev. 2008 Jul;37(7):1402-13 – reference: 18292778 - Nat Rev Mol Cell Biol. 2008 Mar;9(3):206-18 – reference: 21339212 - Ann Rheum Dis. 2011 Mar;70 Suppl 1:i109-12 – reference: 12354379 - Immunity. 2002 Sep;17(3):251-63 – reference: 16397526 - Nat Rev Cancer. 2006 Jan;6(1):38-51 – reference: 17277777 - Nat Genet. 2007 Mar;39(3):311-8 – reference: 7566114 - Nature. 1995 Oct 5;377(6548):397-404 – reference: 19596240 - Cell. 2009 Jul 10;138(1):129-45 – reference: 21258344 - Nat Biotechnol. 2011 Mar;29(3):255-65 – reference: 9422508 - Nature. 1998 Jan 1;391(6662):79-82 – reference: 20832726 - Mol Cell. 2010 Sep 10;39(5):750-60 – reference: 22156208 - Genes Dev. 2011 Dec 1;25(23):2480-8 – reference: 14980219 - Cell. 2004 Feb 20;116(4):511-26 – reference: 18250418 - J Immunol. 2008 Feb 15;180(4):2125-31 – reference: 20141834 - Cell. 2010 Jan 22;140(2):197-208 – reference: 20206554 - Immunity. 2010 Mar 26;32(3):317-28 – reference: 19859064 - Nat Rev Immunol. 2009 Oct;9(10):692-703 – reference: 21068722 - Nature. 2010 Dec 23;468(7327):1119-23 – reference: 17329241 - J Biol Chem. 2007 Apr 20;282(16):11613-7 – reference: 18443042 - Mol Cell Biol. 2008 Jul;28(13):4407-23 – reference: 20436486 - Nat Chem Biol. 2010 Jun;6(6):433-41 – reference: 22048801 - Curr Protoc Immunol. 2011 Nov;Chapter 14:Unit 14.26 – reference: 12434058 - Science. 2002 Nov 15;298(5597):1412-4 – reference: 21343618 - Sci Signal. 2011;4(161):ra11 – reference: 20100935 - J Immunol. 2010 Mar 1;184(5):2718-28 – reference: 21551061 - Science. 2011 May 6;332(6030):717-21 – reference: 20303874 - Cell. 2010 Mar 19;140(6):833-44 – reference: 11711434 - Genes Dev. 2001 Nov 15;15(22):2991-3004 – reference: 20513432 - Mol Cell. 2010 May 28;38(4):576-89 – reference: 21570914 - Trends Immunol. 2011 Jul;32(7):335-43 – reference: 19779457 - EMBO J. 2009 Nov 4;28(21):3341-52 – reference: 20436908 - PLoS Biol. 2010;8(4):e1000361 – reference: 20566897 - Blood. 2010 Oct 14;116(15):2732-41 – reference: 17825402 - Cell. 2007 Sep 21;130(6):1083-94 – reference: 16200064 - Nat Genet. 2005 Nov;37(11):1289-95 – reference: 15708534 - Drug Discov Today. 2005 Feb 1;10(3):197-204 – reference: 10781090 - Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4844-9 – reference: 18599619 - Mol Endocrinol. 2008 Sep;22(9):2076-84
SSID	ssj0009580
Score	2.5559764
Snippet	Histone deacetylases (HDACs) regulate inflammatory gene expression, as indicated by the potent antiinflammatory activity of pan-HDAC inhibitors. However, the...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	E2865
SubjectTerms	Animals Base Sequence Chromatin Immunoprecipitation Cyclooxygenase 1 - metabolism Cytokines - analysis DNA Primers - genetics Enzyme-Linked Immunosorbent Assay Flow Cytometry Gene Expression Regulation - genetics Genomics Histone Deacetylases - deficiency Histone Deacetylases - metabolism Macrophages - metabolism Membrane Proteins - metabolism Mice Mice, Transgenic Molecular Sequence Data Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA
Title	Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages
URI	https://www.ncbi.nlm.nih.gov/pubmed/22802645 https://www.proquest.com/docview/1113214730
Volume	109
WOSCitedRecordID	wos000310515800006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpZ3LSwMxEMaDWg9e1PqsLyJ40ENos5tusicRsfRiKaLQW8ljgj24rW4V_e-d7KbqSQQve8pCyH6Z_JjMfkPImdAJN4ZbpsFmTBhrmeJWMJm4xDudI6X6qtmEHAzUaJQPY8KtjGWVi5hYBWo3tSFH3q5aonOBgrycPbPQNSrcrsYWGsukkSLKhJIuOVI_THdV7UaQc5aJvLOw9pFpe1boMvw-w4PdTOcXvqzOmd7Gf2e4SdYjYdKrWhJNsgTFFmnGPVzS82g0fbFNJncQ6oCrBCFFeKUIg7QyIC6AOoyVMP9AuAbad9qmXyNQkyijp-p6nqL-gMJ7LKctaKz3wkH0SYf2YI8YsMod8tC7ub_us9h6gdluJufMgwAJmffIiybXmQs2XjlwYTreqa7JDUjrU-gKj4QjlVbcO8MNAlzitdHJLlkpcLL7hCZOSB985rPgDShTZXMtUyGskmCNghY5XSznGKUd7it0AdPXcvy9oC2yV3-T8az24BgHFx9kue7BH94-JGuIOUk4cXh2RBoeNzYck1X7Np-ULyeVZvA5GN5-AsQ4zgs
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Requirement+for+the+histone+deacetylase+Hdac3+for+the+inflammatory+gene+expression+program+in+macrophages&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Chen%2C+Xuefen&rft.au=Barozzi%2C+Iros&rft.au=Termanini%2C+Alberto&rft.au=Prosperini%2C+Elena&rft.date=2012-10-16&rft.issn=1091-6490&rft.eissn=1091-6490&rft.volume=109&rft.issue=42&rft.spage=E2865&rft_id=info:doi/10.1073%2Fpnas.1121131109&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1091-6490&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1091-6490&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1091-6490&client=summon