Enhancing immunogenic responses through CDK4/6 and HIF2α inhibition in Merkel cell carcinoma

Approximately 50% of Merkel cell carcinoma (MCC) patients facing this highly aggressive skin cancer initially respond positively to PD-1-based immunotherapy. Nevertheless, the recurrence of MCC post-immunotherapy emphasizes the pressing need for more effective treatments. Recent research has highlig...

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Vydáno v:	Heliyon Ročník 10; číslo 1; s. e23521
Hlavní autoři:	Lee, Jung Hyun, Lee, Justin Daho, Paulson, Kelly, Voillet, Valentin, Berndt, Andre, Church, Candice, Lachance, Kristina, Park, Song Y., Yamamoto, Naomi K., Cromwell, Elizabeth A., Gottardo, Raphael, Chapuis, Aude G., Nghiem, Paul
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 15.01.2024 Elsevier
Témata:	carcinoma CDK4/6 inhibitor cell cycle cell death cyclin-dependent kinase Hypoxia Immunogenic cell death immunotherapy skin neoplasms transcription (genetics) Hypoxia Immunogenic cell death CDK4/6 inhibitor
ISSN:	2405-8440, 2405-8440
On-line přístup:	Získat plný text
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