Enhancing immunogenic responses through CDK4/6 and HIF2α inhibition in Merkel cell carcinoma

Approximately 50% of Merkel cell carcinoma (MCC) patients facing this highly aggressive skin cancer initially respond positively to PD-1-based immunotherapy. Nevertheless, the recurrence of MCC post-immunotherapy emphasizes the pressing need for more effective treatments. Recent research has highlig...

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Bibliographic Details

Published in:	Heliyon Vol. 10; no. 1; p. e23521
Main Authors:	Lee, Jung Hyun, Lee, Justin Daho, Paulson, Kelly, Voillet, Valentin, Berndt, Andre, Church, Candice, Lachance, Kristina, Park, Song Y., Yamamoto, Naomi K., Cromwell, Elizabeth A., Gottardo, Raphael, Chapuis, Aude G., Nghiem, Paul
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15.01.2024 Elsevier
Subjects:	carcinoma CDK4/6 inhibitor cell cycle cell death cyclin-dependent kinase Hypoxia Immunogenic cell death immunotherapy skin neoplasms transcription (genetics) Hypoxia Immunogenic cell death CDK4/6 inhibitor
ISSN:	2405-8440, 2405-8440
Online Access:	Get full text
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