The role of long noncoding RNAs in cancer: the dark matter matters

Sequencing technology has facilitated a new era of cancer research, especially in cancer genomics. Using next-generation sequencing, thousands of long noncoding RNAs (lncRNAs) have been identified as abnormally altered in the cancer genome or differentially expressed in tumor tissues. These lncRNAs...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Current opinion in genetics & development Ročník 48; s. 8 - 15
Hlavní autoři: Hu, Xiaowen, Sood, Anil K, Dang, Chi V, Zhang, Lin
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.02.2018
Témata:
Animals
Humans
Neoplasms - diagnosis
Neoplasms - genetics
Neoplasms - therapy
RNA, Long Noncoding - analysis
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA, Small Interfering - therapeutic use
ISSN:0959-437X, 1879-0380, 1879-0380
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Sequencing technology has facilitated a new era of cancer research, especially in cancer genomics. Using next-generation sequencing, thousands of long noncoding RNAs (lncRNAs) have been identified as abnormally altered in the cancer genome or differentially expressed in tumor tissues. These lncRNAs are associated with imbalanced gene regulation and aberrant biological processes that contribute to malignant transformation. The functions and therapeutic potential of cancer-related lncRNAs have attracted considerable interest in the past few years. Although few lncRNAs have been well-characterized, researchers have recently made impressive progress in understanding lncRNAs and their novel functions, such as regulation of gene expression, metabolism and DNA repair. These latest findings reinforce the crucial roles of lncRNAs in cancer initiation and development, as well as their possible clinical applications.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0959-437X
1879-0380
1879-0380
DOI:10.1016/j.gde.2017.10.004