Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

HuR influences gene expression programs and hence cellular phenotypes by binding to hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular RNAs (circRNAs) and impacts on their function is unknown. Here, we have identified en masse circRNAs binding HuR in human cervical...

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Veröffentlicht in:	RNA biology Jg. 14; H. 3; S. 361 - 369
Hauptverfasser:	Abdelmohsen, Kotb, Panda, Amaresh C., Munk, Rachel, Grammatikakis, Ioannis, Dudekula, Dawood B., De, Supriyo, Kim, Jiyoung, Noh, Ji Heon, Kim, Kyoung Mi, Martindale, Jennifer L., Gorospe, Myriam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Taylor & Francis 04.03.2017
Schlagworte:	Base Sequence Binding Sites Cell Line, Tumor Cell proliferation circPABPN1 circular RNA ELAV-Like Protein 1 - metabolism endogenous competing RNA gene expression Gene Expression Regulation human cell lines human diseases Humans HuR messenger RNA Models, Biological neoplasm cells PABPN1 phenotype Poly(A)-Binding Protein I - genetics polyribosomes Protein Binding Protein Biosynthesis Research Paper RNA - genetics RNA - metabolism RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism RNA-binding Protein translation translation (genetics) uterine cervical neoplasms Cell proliferation HuR PABPN1 circular RNA circPABPN1 translation RNA-binding Protein endogenous competing RNA
ISSN:	1547-6286, 1555-8584, 1555-8584
Online-Zugang:	Volltext
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