SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells

Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with acute coronavirus disease 2019 (COVID-19). However, by which mechan...

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Vydáno v:	Cell reports (Cambridge) Ročník 38; číslo 10; s. 110503
Hlavní autoři:	Hammer, Quirin, Dunst, Josefine, Christ, Wanda, Picarazzi, Francesca, Wendorff, Mareike, Momayyezi, Pouria, Huhn, Oisín, Netskar, Herman K., Maleki, Kimia T., García, Marina, Sekine, Takuya, Sohlberg, Ebba, Azzimato, Valerio, Aouadi, Myriam, Degenhardt, Frauke, Franke, Andre, Spallotta, Francesco, Mori, Mattia, Michaëlsson, Jakob, Björkström, Niklas K., Rückert, Timo, Romagnani, Chiara, Horowitz, Amir, Klingström, Jonas, Ljunggren, Hans-Gustaf, Malmberg, Karl-Johan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 08.03.2022 The Author(s) Elsevier
Témata:	COVID-19 COVID-19 - immunology Histocompatibility Antigens Class I - immunology HLA-E HLA-E Antigens Humans Killer Cells, Natural - immunology Methyltransferases - immunology missing self NK Cell Lectin-Like Receptor Subfamily C - immunology NK Cell Lectin-Like Receptor Subfamily C - metabolism NK cells NKG2A Peptides - metabolism RNA Helicases - immunology SARS-CoV-2 Viral Nonstructural Proteins - immunology COVID-19 NK cells SARS-CoV-2 NKG2A missing self HLA-E
ISSN:	2211-1247, 2211-1247
On-line přístup:	Získat plný text
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