SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells

Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with acute coronavirus disease 2019 (COVID-19). However, by which mechan...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 38; no. 10; p. 110503
Main Authors:	Hammer, Quirin, Dunst, Josefine, Christ, Wanda, Picarazzi, Francesca, Wendorff, Mareike, Momayyezi, Pouria, Huhn, Oisín, Netskar, Herman K., Maleki, Kimia T., García, Marina, Sekine, Takuya, Sohlberg, Ebba, Azzimato, Valerio, Aouadi, Myriam, Degenhardt, Frauke, Franke, Andre, Spallotta, Francesco, Mori, Mattia, Michaëlsson, Jakob, Björkström, Niklas K., Rückert, Timo, Romagnani, Chiara, Horowitz, Amir, Klingström, Jonas, Ljunggren, Hans-Gustaf, Malmberg, Karl-Johan
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 08.03.2022 The Author(s) Elsevier
Subjects:	COVID-19 COVID-19 - immunology Histocompatibility Antigens Class I - immunology HLA-E HLA-E Antigens Humans Killer Cells, Natural - immunology Methyltransferases - immunology missing self NK Cell Lectin-Like Receptor Subfamily C - immunology NK Cell Lectin-Like Receptor Subfamily C - metabolism NK cells NKG2A Peptides - metabolism RNA Helicases - immunology SARS-CoV-2 Viral Nonstructural Proteins - immunology COVID-19 NK cells SARS-CoV-2 NKG2A missing self HLA-E
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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