Phase Separation: Linking Cellular Compartmentalization to Disease

Eukaryotic cells are complex structures capable of coordinating numerous biochemical reactions in space and time. Key to such coordination is the subdivision of intracellular space into functional compartments. Compartmentalization can be achieved by intracellular membranes, which surround organelle...

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Bibliographic Details
Published in:	Trends in cell biology Vol. 26; no. 7; pp. 547 - 558
Main Authors:	Aguzzi, Adriano, Altmeyer, Matthias
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.07.2016
Subjects:	Animals Cell Compartmentation Disease Eukaryotic Cells - metabolism Humans intrinsically disordered proteins liquid demixing low-complexity domains neurodegeneration Pathology Phase Transition protein assembly and aggregation Proteins - metabolism neurodegeneration phase transition intrinsically disordered proteins liquid demixing low-complexity domains protein assembly and aggregation
ISSN:	0962-8924, 1879-3088
Online Access:	Get full text
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