Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

Although macrophages are widely recognized to have a profibrotic role in inflammation, we have used a highly tractable CCl(4)-induced model of reversible hepatic fibrosis to identify and characterize the macrophage phenotype responsible for tissue remodeling: the hitherto elusive restorative macroph...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 46; p. E3186
Main Authors:	Ramachandran, Prakash, Pellicoro, Antonella, Vernon, Madeleine A, Boulter, Luke, Aucott, Rebecca L, Ali, Aysha, Hartland, Stephen N, Snowdon, Victoria K, Cappon, Andrea, Gordon-Walker, Timothy T, Williams, Mike J, Dunbar, Donald R, Manning, Jonathan R, van Rooijen, Nico, Fallowfield, Jonathan A, Forbes, Stuart J, Iredale, John P
Format:	Journal Article
Language:	English
Published:	United States 13.11.2012
Subjects:	Animals Antigens, Ly - genetics Antigens, Ly - immunology Carbon Tetrachloride - toxicity Carbon Tetrachloride Poisoning - genetics Carbon Tetrachloride Poisoning - immunology Carbon Tetrachloride Poisoning - pathology CD11b Antigen - genetics CD11b Antigen - immunology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gene Expression Regulation - immunology Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - immunology Liver Cirrhosis - chemically induced Liver Cirrhosis - genetics Liver Cirrhosis - immunology Liver Cirrhosis - pathology Macrophages - immunology Macrophages - pathology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics MAP Kinase Signaling System - immunology Matrix Metalloproteinase 12 - genetics Matrix Metalloproteinase 12 - immunology Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - immunology Mice Mice, Transgenic Monocytes - immunology Monocytes - pathology
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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