Rosmarinic acid represses colitis-associated colon cancer: A pivotal involvement of the TLR4-mediated NF-κB-STAT3 axis

Previously, we found that rosmarinic acid (RA) exerted anti-inflammatory activities in a dextran sulfate sodium (DSS)-induced colitis model. Here, we investigated the anti-tumor effects of RA on colitis-associated colon cancer (CAC) and the underlying molecular mechanisms. We established an azoxymet...

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Bibliographic Details
Published in:	Neoplasia (New York, N.Y.) Vol. 23; no. 6; pp. 561 - 573
Main Authors:	Jin, Bo-Ram, Chung, Kyung-Sook, Hwang, Soonjae, Hwang, Sam Noh, Rhee, Ki-Jong, Lee, Minho, An, Hyo-Jin
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.06.2021 Neoplasia Press Elsevier
Subjects:	Animals Biomarkers Cell Line, Tumor Cinnamates - chemistry Cinnamates - pharmacology Colitis-associated colon cancer (CAC) Colitis-Associated Neoplasms - drug therapy Colitis-Associated Neoplasms - etiology Colitis-Associated Neoplasms - metabolism Colitis-Associated Neoplasms - pathology Colonic Neoplasms - drug therapy Colonic Neoplasms - etiology Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Depsides - chemistry Depsides - pharmacology Disease Models, Animal Humans Immunohistochemistry Male Mice Models, Molecular Myeloid differentiation factor 2 (MD-2) NF-kappa B - metabolism Nuclear factor-kappa B (NF-κB) Original Research Rosmarinic Acid Rosmarinic acid (RA) Signal transducer and activator of transcription 3 (STAT3) Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Structure-Activity Relationship Toll-Like Receptor 4 - metabolism Toll-like receptor-4 (TLR4) Xenograft Model Antitumor Assays CAC Rosmarinic acid (RA) DSS IHC CPT STAT3 Myeloid differentiation factor 2 (MD-2) IBD Toll-like receptor-4 (TLR4) UC Colitis-associated colon cancer (CAC) RA Signal transducer and activator of transcription 3 (STAT3) NF-κB CRC Nuclear factor-kappa B (NF-κB) TLR4 AOM
ISSN:	1476-5586, 1522-8002, 1476-5586
Online Access:	Get full text
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