Rosmarinic acid represses colitis-associated colon cancer: A pivotal involvement of the TLR4-mediated NF-κB-STAT3 axis
Previously, we found that rosmarinic acid (RA) exerted anti-inflammatory activities in a dextran sulfate sodium (DSS)-induced colitis model. Here, we investigated the anti-tumor effects of RA on colitis-associated colon cancer (CAC) and the underlying molecular mechanisms. We established an azoxymet...
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| Vydané v: | Neoplasia (New York, N.Y.) Ročník 23; číslo 6; s. 561 - 573 |
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| Hlavní autori: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
Elsevier Inc
01.06.2021
Neoplasia Press Elsevier |
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| ISSN: | 1476-5586, 1522-8002, 1476-5586 |
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| Abstract | Previously, we found that rosmarinic acid (RA) exerted anti-inflammatory activities in a dextran sulfate sodium (DSS)-induced colitis model. Here, we investigated the anti-tumor effects of RA on colitis-associated colon cancer (CAC) and the underlying molecular mechanisms. We established an azoxymethane (AOM)/DSS-induced CAC murine model for in vivo studies and used a conditioned media (CM) culture system in vitro. H&E staining, immunohistochemistry, western blot assay, enzyme-linked immunosorbent assay, molecular docking, co-immunoprecipitation, and immunofluorescence assay were utilized to investigate how RA prevented colorectal cancer. In the AOM/DSS-induced CAC murine model, RA significantly reduced colitis severity, inflammation-related protein expression, tumor incidence, and colorectal adenoma development. It significantly modulated toll-like receptor-4 (TLR4)-mediated nuclear factor-kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) activation, thus attenuating the expression of anti-apoptotic factors, which mediate transcription factor-dependent tumor growth. In vitro, RA inhibited CM-induced TLR4 overexpression and competitively inhibited TLR4-myeloid differentiation factor 2 complex in an inflammatory microenvironment. Thus, RA suppressed NF-κB and STAT3 activation in colon cancer cells in an inflammatory microenvironment. Therefore, RA suppressed colitis-associated tumorigenesis in the AOM/DSS-induced CAC murine model and abrogated human colon cancer progression in an inflammatory microenvironment by propitiating TLR4-mediated NF-κB and STAT3 activation, pleiotropically. |
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| AbstractList | Previously, we found that rosmarinic acid (RA) exerted anti-inflammatory activities in a dextran sulfate sodium (DSS)-induced colitis model. Here, we investigated the anti-tumor effects of RA on colitis-associated colon cancer (CAC) and the underlying molecular mechanisms. We established an azoxymethane (AOM)/DSS-induced CAC murine model for in vivo studies and used a conditioned media (CM) culture system in vitro. H&E staining, immunohistochemistry, western blot assay, enzyme-linked immunosorbent assay, molecular docking, co-immunoprecipitation, and immunofluorescence assay were utilized to investigate how RA prevented colorectal cancer. In the AOM/DSS-induced CAC murine model, RA significantly reduced colitis severity, inflammation-related protein expression, tumor incidence, and colorectal adenoma development. It significantly modulated toll-like receptor-4 (TLR4)-mediated nuclear factor-kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) activation, thus attenuating the expression of anti-apoptotic factors, which mediate transcription factor-dependent tumor growth. In vitro, RA inhibited CM-induced TLR4 overexpression and competitively inhibited TLR4-myeloid differentiation factor 2 complex in an inflammatory microenvironment. Thus, RA suppressed NF-κB and STAT3 activation in colon cancer cells in an inflammatory microenvironment. Therefore, RA suppressed colitis-associated tumorigenesis in the AOM/DSS-induced CAC murine model and abrogated human colon cancer progression in an inflammatory microenvironment by propitiating TLR4-mediated NF-κB and STAT3 activation, pleiotropically. Previously, we found that rosmarinic acid (RA) exerted anti-inflammatory activities in a dextran sulfate sodium (DSS)-induced colitis model. Here, we investigated the anti-tumor effects of RA on colitis-associated colon cancer (CAC) and the underlying molecular mechanisms. We established an azoxymethane (AOM)/DSS-induced CAC murine model for in vivo studies and used a conditioned media (CM) culture system in vitro. H&E staining, immunohistochemistry, western blot assay, enzyme-linked immunosorbent assay, molecular docking, co-immunoprecipitation, and immunofluorescence assay were utilized to investigate how RA prevented colorectal cancer. In the AOM/DSS-induced CAC murine model, RA significantly reduced colitis severity, inflammation-related protein expression, tumor incidence, and colorectal adenoma development. It significantly modulated toll-like receptor-4 (TLR4)-mediated nuclear factor-kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) activation, thus attenuating the expression of anti-apoptotic factors, which mediate transcription factor-dependent tumor growth. In vitro, RA inhibited CM-induced TLR4 overexpression and competitively inhibited TLR4-myeloid differentiation factor 2 complex in an inflammatory microenvironment. Thus, RA suppressed NF-κB and STAT3 activation in colon cancer cells in an inflammatory microenvironment. Therefore, RA suppressed colitis-associated tumorigenesis in the AOM/DSS-induced CAC murine model and abrogated human colon cancer progression in an inflammatory microenvironment by propitiating TLR4-mediated NF-κB and STAT3 activation, pleiotropically.Previously, we found that rosmarinic acid (RA) exerted anti-inflammatory activities in a dextran sulfate sodium (DSS)-induced colitis model. Here, we investigated the anti-tumor effects of RA on colitis-associated colon cancer (CAC) and the underlying molecular mechanisms. We established an azoxymethane (AOM)/DSS-induced CAC murine model for in vivo studies and used a conditioned media (CM) culture system in vitro. H&E staining, immunohistochemistry, western blot assay, enzyme-linked immunosorbent assay, molecular docking, co-immunoprecipitation, and immunofluorescence assay were utilized to investigate how RA prevented colorectal cancer. In the AOM/DSS-induced CAC murine model, RA significantly reduced colitis severity, inflammation-related protein expression, tumor incidence, and colorectal adenoma development. It significantly modulated toll-like receptor-4 (TLR4)-mediated nuclear factor-kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) activation, thus attenuating the expression of anti-apoptotic factors, which mediate transcription factor-dependent tumor growth. In vitro, RA inhibited CM-induced TLR4 overexpression and competitively inhibited TLR4-myeloid differentiation factor 2 complex in an inflammatory microenvironment. Thus, RA suppressed NF-κB and STAT3 activation in colon cancer cells in an inflammatory microenvironment. Therefore, RA suppressed colitis-associated tumorigenesis in the AOM/DSS-induced CAC murine model and abrogated human colon cancer progression in an inflammatory microenvironment by propitiating TLR4-mediated NF-κB and STAT3 activation, pleiotropically. |
| Author | Hwang, Soonjae Lee, Minho Chung, Kyung-Sook Hwang, Sam Noh An, Hyo-Jin Jin, Bo-Ram Rhee, Ki-Jong |
| Author_xml | – sequence: 1 givenname: Bo-Ram surname: Jin fullname: Jin, Bo-Ram organization: Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do, Korea – sequence: 2 givenname: Kyung-Sook surname: Chung fullname: Chung, Kyung-Sook organization: Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea – sequence: 3 givenname: Soonjae surname: Hwang fullname: Hwang, Soonjae organization: Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University at Wonju, Wonju-si, Gangwon-do, Republic of Korea – sequence: 4 givenname: Sam Noh surname: Hwang fullname: Hwang, Sam Noh organization: Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University at Wonju, Wonju-si, Gangwon-do, Republic of Korea – sequence: 5 givenname: Ki-Jong surname: Rhee fullname: Rhee, Ki-Jong organization: Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University at Wonju, Wonju-si, Gangwon-do, Republic of Korea – sequence: 6 givenname: Minho orcidid: 0000-0002-0168-9546 surname: Lee fullname: Lee, Minho email: MinhoLee@dgu.edu organization: Department of Life Science, Dongguk University-Seoul, Goyang-si, Gyeonggi-do, Republic of Korea – sequence: 7 givenname: Hyo-Jin orcidid: 0000-0002-2937-874X surname: An fullname: An, Hyo-Jin email: sangjipharm@gmail.com organization: Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34077834$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.molimm.2008.01.025 10.3390/nu10020202 10.7150/ijbs.6.675 10.4049/jimmunol.1002971 10.4103/1477-3163.78279 10.18632/oncotarget.13715 10.1002/path.876 10.1039/C4FO01051E 10.1002/ijc.23173 10.1016/j.cell.2007.08.002 10.1158/1078-0432.CCR-08-0149 10.1038/ni0302-221 10.1016/j.cell.2006.01.007 10.1002/ibd.20880 10.1016/j.ejca.2013.06.005 10.1038/s41598-018-37421-w 10.1016/j.canlet.2008.03.028 10.1016/j.etap.2012.07.014 10.1002/eji.201344341 10.1615/JEnvironPatholToxicolOncol.v30.i3.30 10.18383/j.tom.2017.00021 10.1248/bpb.28.173 10.1111/j.1349-7006.2003.tb01386.x 10.1159/000490829 10.1038/s41419-020-2399-y 10.1002/jcc.21334 10.1128/IAI.00814-08 10.3389/fimmu.2012.00107 10.1152/ajpcell.00026.2003 10.3892/ijo.2014.2259 10.1152/ajpgi.00079.2004 10.1016/j.fct.2014.11.007 10.1097/01.mcg.0000212654.28527.d0 10.1093/protein/8.2.127 10.1055/s-0035-1568274 10.1634/theoncologist.11-9-1003 10.1002/ibd.21527 10.7314/APJCP.2014.15.2.551 10.1016/S0140-6736(11)61049-0 10.1634/theoncologist.6-suppl_4-17 10.1111/j.1582-4934.2010.01127.x 10.1155/2016/6978936 10.4066/biomedicalresearch.29-17-2928 10.2174/138161209788453167 10.1038/nrd2781 10.1038/srep46252 10.1016/j.semcancer.2019.05.001 10.1038/ni.3384 |
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| Keywords | CAC Rosmarinic acid (RA) DSS IHC CPT STAT3 Myeloid differentiation factor 2 (MD-2) IBD Toll-like receptor-4 (TLR4) UC Colitis-associated colon cancer (CAC) RA Signal transducer and activator of transcription 3 (STAT3) NF-κB CRC Nuclear factor-kappa B (NF-κB) TLR4 AOM |
| Language | English |
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| References | Okugawa, Ota, Kitazawa, Nakayama, Yanagimoto, Tsukada, Kawada, Kimura (bib0055) 2003; 285 Keibel, Singh, Sharma (bib0005) 2009; 15 Siegel, Miller, Jemal (bib0001) 2016; 66 Fukata, Shang, Santaolalla, Sotolongo, Pastorini, Espana, Ungaro, Harpaz, Cooper, Elson (bib0006) 2011; 17 Lasry, Zinger, Ben-Neriah (bib0030) 2016; 17 So, Ouchi (bib0048) 2010; 6 Amoah, Sandjo, Kratz, Biavatti (bib0011) 2016; 82 Rubin, Shaker, Levin (bib0041) 2012; 3 Chockalingam, Muruhan (bib0015) 2017; 8 Molteni, Gemma, Rossetti (bib0050) 2016; 2016 Trott, Olson (bib0020) 2010; 31 Greenhill, Rose-John, Lissilaa, Ferlin, Ernst, Hertzog, Mansell, Jenkins (bib0049) 2011; 186 Sica, Allavena, Mantovani (bib0004) 2008; 267 Verzella, Pescatore, Capece, Vecchiotti, Ursini, Franzoso, Alesse, Zazzeroni (bib0044) 2020; 11 Qiu, Ma, Wang, Zhang (bib0035) 2017; 8 Cunningham, Maroun, Vanhoefer, Van Cutsem (bib0037) 2001; 6 Yu, Wang, Chen (bib0051) 2010; 14 Eaden, Abrams, McKay, Denley, Mayberry (bib0002) 2001; 194 Chung, Cheon, Roh, Lee, An (bib0019) 2018; 10 Rhee, Wu, Wu, Huso, Karim, Franco, Rabizadeh, Golub, Mathews, Shin (bib0018) 2009; 77 Aggarwal, Vijayalekshmi, Sung (bib0029) 2009; 15 Karthikkumar, Sivagami, Vinothkumar, Rajkumar, Nalini (bib0017) 2012; 34 Sun, Liu, Zheng, Cao (bib0026) 2008; 45 Jin, Chung, Cheon, Lee, Hwang, Noh Hwang, Rhee, An (bib0016) 2017; 7 Wang, Sun (bib0045) 2014; 44 Tanaka, Kohno, Suzuki, Yamada, Sugie, Mori (bib0040) 2003; 94 Huang, Zhang, Cao, Wang, Liu, Peng, Ren, Qian (bib0007) 2014; 18 Cohen, Das (bib0036) 2006; 40 Multhoff, Molls, Radons (bib0008) 2011; 2 Cochet, Facchini, Zaffaroni, Billod, Coelho, Holgado, Braun, Beyaert, Jerala, Jimenez-Barbero (bib0028) 2019; 9 Itzkowitz, Yio (bib0032) 2004; 287 Karin, Lin (bib0043) 2002; 3 Yoshida, Fuchigami, Nagao, Okabe, Matsunaga, Takata, Karube, Tsuchihashi, Kinjo, Mihashi (bib0012) 2005; 28 Wallace, Laskowski, Thornton (bib0023) 1995; 8 Hussain, Harris (bib0031) 2007; 121 MacDonald (bib0038) 2009; 50 Anusuya, Manoharan (bib0013) 2011; 30 Zhou, Xia, Liu, Wang, Lin, Oyang, Chen, Luo, Tan, Tian (bib0054) 2018; 47 DeLano (bib0022) 2002; 40 Zhang, Sime, Juhas, Sjolander (bib0053) 2013; 49 Burn, Gerdes, Macrae, Mecklin, Moeslein, Olschwang, Eccles, Evans, Maher, Bertario (bib0033) 2011; 378 Xin–hua, Rui–yu (bib0046) 2012; 7 De Robertis, Massi, Poeta, Carotti, Morini, Cecchetelli, Signori, Fazio (bib0024) 2011; 10 Nadeem MS, Kumar V, Al-Abbasi FA, Kamal MA, Anwar F. Risk of colorectal cancer in inflammatory bowel diseases. Seminars in cancer biololgy 64, 51–60. Schmoll, Arnold (bib0039) 2006; 11 Liu, Cao, Huizinga, Hafler, Toes (bib0009) 2014; 44 Baud, Karin (bib0042) 2009; 8 Pandurangan, Esa (bib0010) 2014; 15 Fukata, Hernandez, Conduah, Cohen, Chen, Breglio, Goo, Hsu, Xu, Abreu (bib0047) 2009; 15 Zhou L, Liang H-Z, Zhang H, Wang X-Y, Xu D, Wu J (2018). Significance of TLR4, MyD88 and STAT3 expression in colorectal cancer. Condeelis, Pollard (bib0052) 2006; 124 Kim, Park, Kim, Kim, Lee, Oh, Enkhbayar, Matsushima, Lee, Yoo (bib0021) 2007; 130 Biton, Stettner, Brener, Erez, Harmelin, Garbow (bib0025) 2018; 4 Chung, Choi, Shin, Cho, Cho, Choi, Baek, Lee (bib0034) 2015; 75 Zhang, Chen, Yang, Zu, Lu (bib0014) 2015; 6 Greenhill (10.1016/j.neo.2021.05.002_bib0049) 2011; 186 Karin (10.1016/j.neo.2021.05.002_bib0043) 2002; 3 Rhee (10.1016/j.neo.2021.05.002_bib0018) 2009; 77 Aggarwal (10.1016/j.neo.2021.05.002_bib0029) 2009; 15 Yu (10.1016/j.neo.2021.05.002_bib0051) 2010; 14 Zhang (10.1016/j.neo.2021.05.002_bib0053) 2013; 49 Fukata (10.1016/j.neo.2021.05.002_bib0047) 2009; 15 Huang (10.1016/j.neo.2021.05.002_bib0007) 2014; 18 Pandurangan (10.1016/j.neo.2021.05.002_bib0010) 2014; 15 Keibel (10.1016/j.neo.2021.05.002_bib0005) 2009; 15 Sun (10.1016/j.neo.2021.05.002_bib0026) 2008; 45 Cochet (10.1016/j.neo.2021.05.002_bib0028) 2019; 9 Molteni (10.1016/j.neo.2021.05.002_bib0050) 2016; 2016 Eaden (10.1016/j.neo.2021.05.002_bib0002) 2001; 194 Amoah (10.1016/j.neo.2021.05.002_bib0011) 2016; 82 Jin (10.1016/j.neo.2021.05.002_bib0016) 2017; 7 Okugawa (10.1016/j.neo.2021.05.002_bib0055) 2003; 285 Cohen (10.1016/j.neo.2021.05.002_bib0036) 2006; 40 Chockalingam (10.1016/j.neo.2021.05.002_bib0015) 2017; 8 Trott (10.1016/j.neo.2021.05.002_bib0020) 2010; 31 Karthikkumar (10.1016/j.neo.2021.05.002_bib0017) 2012; 34 So (10.1016/j.neo.2021.05.002_bib0048) 2010; 6 Liu (10.1016/j.neo.2021.05.002_bib0009) 2014; 44 Zhou (10.1016/j.neo.2021.05.002_bib0054) 2018; 47 Kim (10.1016/j.neo.2021.05.002_bib0021) 2007; 130 Wang (10.1016/j.neo.2021.05.002_bib0045) 2014; 44 Burn (10.1016/j.neo.2021.05.002_bib0033) 2011; 378 Verzella (10.1016/j.neo.2021.05.002_bib0044) 2020; 11 Siegel (10.1016/j.neo.2021.05.002_bib0001) 2016; 66 10.1016/j.neo.2021.05.002_bib0003 Biton (10.1016/j.neo.2021.05.002_bib0025) 2018; 4 Hussain (10.1016/j.neo.2021.05.002_bib0031) 2007; 121 Itzkowitz (10.1016/j.neo.2021.05.002_bib0032) 2004; 287 MacDonald (10.1016/j.neo.2021.05.002_bib0038) 2009; 50 Anusuya (10.1016/j.neo.2021.05.002_bib0013) 2011; 30 DeLano (10.1016/j.neo.2021.05.002_bib0022) 2002; 40 Lasry (10.1016/j.neo.2021.05.002_bib0030) 2016; 17 Yoshida (10.1016/j.neo.2021.05.002_bib0012) 2005; 28 Xin–hua (10.1016/j.neo.2021.05.002_bib0046) 2012; 7 Rubin (10.1016/j.neo.2021.05.002_bib0041) 2012; 3 Fukata (10.1016/j.neo.2021.05.002_bib0006) 2011; 17 Baud (10.1016/j.neo.2021.05.002_bib0042) 2009; 8 Sica (10.1016/j.neo.2021.05.002_bib0004) 2008; 267 Condeelis (10.1016/j.neo.2021.05.002_bib0052) 2006; 124 Multhoff (10.1016/j.neo.2021.05.002_bib0008) 2011; 2 Cunningham (10.1016/j.neo.2021.05.002_bib0037) 2001; 6 Chung (10.1016/j.neo.2021.05.002_bib0019) 2018; 10 Wallace (10.1016/j.neo.2021.05.002_bib0023) 1995; 8 Tanaka (10.1016/j.neo.2021.05.002_bib0040) 2003; 94 Schmoll (10.1016/j.neo.2021.05.002_bib0039) 2006; 11 Zhang (10.1016/j.neo.2021.05.002_bib0014) 2015; 6 De Robertis (10.1016/j.neo.2021.05.002_bib0024) 2011; 10 Qiu (10.1016/j.neo.2021.05.002_bib0035) 2017; 8 Chung (10.1016/j.neo.2021.05.002_bib0034) 2015; 75 10.1016/j.neo.2021.05.002_bib0027 |
| References_xml | – volume: 18 start-page: 3834 year: 2014 end-page: 3843 ident: bib0007 article-title: The TLR4/NF-kappaB signaling pathway mediates the growth of colon cancer publication-title: Euro rev for med and pharmacol sci – volume: 9 start-page: 919 year: 2019 ident: bib0028 article-title: Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties publication-title: Scientific rep – volume: 186 start-page: 1199 year: 2011 end-page: 1208 ident: bib0049 article-title: IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3 publication-title: J Immunol – volume: 10 year: 2018 ident: bib0019 article-title: Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice publication-title: Nutrients – volume: 47 start-page: 1399 year: 2018 end-page: 1410 ident: bib0054 article-title: Induction of Pro-Inflammatory Response via Activated Macrophage-Mediated NF-kappaB and STAT3 Pathways in Gastric Cancer Cells publication-title: Cellular physiol and biochemistry: int j experimental cellular physiology, biochemistry, and pharmacol – volume: 15 start-page: 1949 year: 2009 end-page: 1955 ident: bib0005 article-title: Inflammation, microenvironment, and the immune system in cancer progression publication-title: Curr Pharm Des – volume: 34 start-page: 949 year: 2012 end-page: 958 ident: bib0017 article-title: Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1,2-dimethylhydrazine induced rat colon carcinogenesis publication-title: Environmental toxicol and pharmacol – volume: 130 start-page: 906 year: 2007 end-page: 917 ident: bib0021 article-title: Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran publication-title: Cell – volume: 8 start-page: 127 year: 1995 end-page: 134 ident: bib0023 article-title: LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions publication-title: Protein Eng – volume: 11 start-page: 210 year: 2020 ident: bib0044 article-title: Life, death, and autophagy in cancer: NF-kappaB turns up everywhere publication-title: Cell death & dis – volume: 14 start-page: 2592 year: 2010 end-page: 2603 ident: bib0051 article-title: Endogenous toll-like receptor ligands and their biological significance publication-title: J cellular and molecular med – volume: 40 start-page: 82 year: 2002 end-page: 92 ident: bib0022 article-title: Pymol: An open-source molecular graphics tool publication-title: CCP4 Newsletter On Protein Crystallography – volume: 82 start-page: 388 year: 2016 end-page: 406 ident: bib0011 article-title: Rosmarinic acid–pharmaceutical and clinical aspects publication-title: Planta Med – volume: 30 start-page: 199 year: 2011 end-page: 211 ident: bib0013 article-title: Antitumor initiating potential of rosmarinic acid in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis publication-title: J environmental pathol, toxicol and oncol: off organ of the Int Soc for Environmental Toxicol and Cancer – volume: 31 start-page: 455 year: 2010 end-page: 461 ident: bib0020 article-title: AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading publication-title: J Comput Chem – volume: 285 start-page: C399 year: 2003 end-page: C408 ident: bib0055 article-title: Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages publication-title: Am J physiol Cell physiol – volume: 2016 year: 2016 ident: bib0050 article-title: The role of toll-like receptor 4 in infectious and noninfectious inflammation publication-title: Mediators Inflamm – volume: 7 start-page: 19 year: 2012 end-page: 24 ident: bib0046 article-title: Progress in research on correlation among STAT3, CyclinD1, P21 genes and tumors publication-title: Journal of Otol – volume: 17 start-page: 1464 year: 2011 end-page: 1473 ident: bib0006 article-title: Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis publication-title: Inflammatory bowel dis – volume: 3 start-page: 107 year: 2012 ident: bib0041 article-title: Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer publication-title: Frontiers in immunol – volume: 6 start-page: 675 year: 2010 end-page: 681 ident: bib0048 article-title: The application of Toll like receptors for cancer therapy publication-title: Int J biol sci – volume: 40 start-page: S150 year: 2006 end-page: S154 ident: bib0036 article-title: The metabolism of mesalamine and its possible use in colonic diverticulitis as an anti-inflammatory agent publication-title: J clin gastroenterol – volume: 8 start-page: 33 year: 2009 end-page: 40 ident: bib0042 article-title: Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls publication-title: Nature rev Drug discovery – volume: 11 start-page: 1003 year: 2006 end-page: 1009 ident: bib0039 article-title: Update on capecitabine in colorectal cancer publication-title: The oncol – volume: 77 start-page: 1708 year: 2009 end-page: 1718 ident: bib0018 article-title: Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice publication-title: Infect Immun – reference: Zhou L, Liang H-Z, Zhang H, Wang X-Y, Xu D, Wu J (2018). Significance of TLR4, MyD88 and STAT3 expression in colorectal cancer. – volume: 6 start-page: 17 year: 2001 end-page: 23 ident: bib0037 article-title: Optimizing the use of irinotecan in colorectal cancer publication-title: The oncol – volume: 267 start-page: 204 year: 2008 end-page: 215 ident: bib0004 article-title: Cancer related inflammation: the macrophage connection publication-title: Cancer Lett – volume: 287 start-page: G7 year: 2004 end-page: 17 ident: bib0032 article-title: Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation publication-title: Am J physiol Gastrointestinal and liver physiol – volume: 6 start-page: 927 year: 2015 end-page: 931 ident: bib0014 article-title: Effects of rosmarinic acid on liver and kidney antioxidant enzymes, lipid peroxidation and tissue ultrastructure in aging mice publication-title: Food & function – volume: 45 start-page: 2929 year: 2008 end-page: 2936 ident: bib0026 article-title: Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation publication-title: Molecular immunol – volume: 44 start-page: 2121 year: 2014 end-page: 2129 ident: bib0009 article-title: TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells publication-title: Eur j immunol – volume: 10 start-page: 9 year: 2011 ident: bib0024 article-title: The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies publication-title: J carcinogenesis – reference: Nadeem MS, Kumar V, Al-Abbasi FA, Kamal MA, Anwar F. Risk of colorectal cancer in inflammatory bowel diseases. Seminars in cancer biololgy 64, 51–60. – volume: 4 start-page: 4 year: 2018 end-page: 13 ident: bib0025 article-title: Assessing mucosal inflammation in a DSS-induced colitis mouse model by MR colonography publication-title: Tomography – volume: 50 start-page: 665 year: 2009 end-page: 668 ident: bib0038 article-title: Chemotherapy: managing side effects and safe handling publication-title: The Canadian veterinary J = La revue veterinaire canadienne – volume: 66 start-page: 7 year: 2016 end-page: 30 ident: bib0001 article-title: Cancer statistics, 2016 publication-title: CA: a cancer j for clin – volume: 8 start-page: 1031 year: 2017 end-page: 1045 ident: bib0035 article-title: Chemopreventive effects of 5-aminosalicylic acid on inflammatory bowel disease-associated colorectal cancer and dysplasia: a systematic review with meta-analysis publication-title: Oncotarget – volume: 194 start-page: 152 year: 2001 end-page: 157 ident: bib0002 article-title: Inter-observer variation between general and specialist gastrointestinal pathologists when grading dysplasia in ulcerative colitis publication-title: The J pathol – volume: 378 start-page: 2081 year: 2011 end-page: 2087 ident: bib0033 article-title: Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial publication-title: Lancet – volume: 49 start-page: 3320 year: 2013 end-page: 3334 ident: bib0053 article-title: Crosstalk between colon cancer cells and macrophages via inflammatory mediators and CD47 promotes tumour cell migration publication-title: Eur J cancer – volume: 44 start-page: 1032 year: 2014 end-page: 1040 ident: bib0045 article-title: The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (Review) publication-title: Int J Oncol – volume: 15 start-page: 425 year: 2009 end-page: 430 ident: bib0029 article-title: Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe publication-title: Clin cancer res: an off J Am Assoc for Cancer Res – volume: 75 start-page: 14 year: 2015 end-page: 23 ident: bib0034 article-title: Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-kappaB inactivation on colitis-associated colon tumorigenesis in mice publication-title: Food and chemical toxicol: an int J published for the Br Industrial Biol Res Assoc – volume: 15 start-page: 551 year: 2014 end-page: 560 ident: bib0010 article-title: Signal transducer and activator of transcription 3 - a promising target in colitis-associated cancer publication-title: Asian Pacific j cancer prevention: APJCP – volume: 7 start-page: 46252 year: 2017 ident: bib0016 article-title: Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-kappaB and STAT3 activation publication-title: Scientific rep – volume: 121 start-page: 2373 year: 2007 end-page: 2380 ident: bib0031 article-title: Inflammation and cancer: an ancient link with novel potentials publication-title: Int J Cancer – volume: 17 start-page: 230 year: 2016 end-page: 240 ident: bib0030 article-title: Inflammatory networks underlying colorectal cancer publication-title: Nature Immunol – volume: 2 start-page: 98 year: 2011 ident: bib0008 article-title: Chronic inflammation in cancer development publication-title: Frontiers in immunol – volume: 8 start-page: 656 year: 2017 end-page: 662 ident: bib0015 article-title: Anti-inflammatory properties of rosmarinic acid-a review publication-title: Int J Res in Pharmaceutical Sci – volume: 15 start-page: 997 year: 2009 end-page: 1006 ident: bib0047 article-title: Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors publication-title: Inflammatory bowel dis – volume: 94 start-page: 965 year: 2003 end-page: 973 ident: bib0040 article-title: A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate publication-title: Cancer sci – volume: 28 start-page: 173 year: 2005 end-page: 175 ident: bib0012 article-title: Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica publication-title: Biol & pharmaceutical bulletin – volume: 124 start-page: 263 year: 2006 end-page: 266 ident: bib0052 article-title: Macrophages: obligate partners for tumor cell migration, invasion, and metastasis publication-title: Cell – volume: 3 start-page: 221 year: 2002 end-page: 227 ident: bib0043 article-title: NF-kappaB at the crossroads of life and death publication-title: Nature immunol – volume: 45 start-page: 2929 year: 2008 ident: 10.1016/j.neo.2021.05.002_bib0026 article-title: Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation publication-title: Molecular immunol doi: 10.1016/j.molimm.2008.01.025 – volume: 10 year: 2018 ident: 10.1016/j.neo.2021.05.002_bib0019 article-title: Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice publication-title: Nutrients doi: 10.3390/nu10020202 – volume: 18 start-page: 3834 year: 2014 ident: 10.1016/j.neo.2021.05.002_bib0007 article-title: The TLR4/NF-kappaB signaling pathway mediates the growth of colon cancer publication-title: Euro rev for med and pharmacol sci – volume: 6 start-page: 675 year: 2010 ident: 10.1016/j.neo.2021.05.002_bib0048 article-title: The application of Toll like receptors for cancer therapy publication-title: Int J biol sci doi: 10.7150/ijbs.6.675 – volume: 186 start-page: 1199 year: 2011 ident: 10.1016/j.neo.2021.05.002_bib0049 article-title: IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3 publication-title: J Immunol doi: 10.4049/jimmunol.1002971 – volume: 10 start-page: 9 year: 2011 ident: 10.1016/j.neo.2021.05.002_bib0024 article-title: The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies publication-title: J carcinogenesis doi: 10.4103/1477-3163.78279 – volume: 50 start-page: 665 year: 2009 ident: 10.1016/j.neo.2021.05.002_bib0038 article-title: Chemotherapy: managing side effects and safe handling publication-title: The Canadian veterinary J = La revue veterinaire canadienne – volume: 8 start-page: 1031 year: 2017 ident: 10.1016/j.neo.2021.05.002_bib0035 article-title: Chemopreventive effects of 5-aminosalicylic acid on inflammatory bowel disease-associated colorectal cancer and dysplasia: a systematic review with meta-analysis publication-title: Oncotarget doi: 10.18632/oncotarget.13715 – volume: 194 start-page: 152 year: 2001 ident: 10.1016/j.neo.2021.05.002_bib0002 article-title: Inter-observer variation between general and specialist gastrointestinal pathologists when grading dysplasia in ulcerative colitis publication-title: The J pathol doi: 10.1002/path.876 – volume: 6 start-page: 927 year: 2015 ident: 10.1016/j.neo.2021.05.002_bib0014 article-title: Effects of rosmarinic acid on liver and kidney antioxidant enzymes, lipid peroxidation and tissue ultrastructure in aging mice publication-title: Food & function doi: 10.1039/C4FO01051E – volume: 121 start-page: 2373 year: 2007 ident: 10.1016/j.neo.2021.05.002_bib0031 article-title: Inflammation and cancer: an ancient link with novel potentials publication-title: Int J Cancer doi: 10.1002/ijc.23173 – volume: 130 start-page: 906 year: 2007 ident: 10.1016/j.neo.2021.05.002_bib0021 article-title: Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran publication-title: Cell doi: 10.1016/j.cell.2007.08.002 – volume: 15 start-page: 425 year: 2009 ident: 10.1016/j.neo.2021.05.002_bib0029 article-title: Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe publication-title: Clin cancer res: an off J Am Assoc for Cancer Res doi: 10.1158/1078-0432.CCR-08-0149 – volume: 3 start-page: 221 year: 2002 ident: 10.1016/j.neo.2021.05.002_bib0043 article-title: NF-kappaB at the crossroads of life and death publication-title: Nature immunol doi: 10.1038/ni0302-221 – volume: 124 start-page: 263 year: 2006 ident: 10.1016/j.neo.2021.05.002_bib0052 article-title: Macrophages: obligate partners for tumor cell migration, invasion, and metastasis publication-title: Cell doi: 10.1016/j.cell.2006.01.007 – volume: 15 start-page: 997 year: 2009 ident: 10.1016/j.neo.2021.05.002_bib0047 article-title: Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors publication-title: Inflammatory bowel dis doi: 10.1002/ibd.20880 – volume: 49 start-page: 3320 year: 2013 ident: 10.1016/j.neo.2021.05.002_bib0053 article-title: Crosstalk between colon cancer cells and macrophages via inflammatory mediators and CD47 promotes tumour cell migration publication-title: Eur J cancer doi: 10.1016/j.ejca.2013.06.005 – volume: 9 start-page: 919 year: 2019 ident: 10.1016/j.neo.2021.05.002_bib0028 article-title: Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties publication-title: Scientific rep doi: 10.1038/s41598-018-37421-w – volume: 8 start-page: 656 year: 2017 ident: 10.1016/j.neo.2021.05.002_bib0015 article-title: Anti-inflammatory properties of rosmarinic acid-a review publication-title: Int J Res in Pharmaceutical Sci – volume: 40 start-page: 82 year: 2002 ident: 10.1016/j.neo.2021.05.002_bib0022 article-title: Pymol: An open-source molecular graphics tool publication-title: CCP4 Newsletter On Protein Crystallography – volume: 267 start-page: 204 year: 2008 ident: 10.1016/j.neo.2021.05.002_bib0004 article-title: Cancer related inflammation: the macrophage connection publication-title: Cancer Lett doi: 10.1016/j.canlet.2008.03.028 – volume: 34 start-page: 949 year: 2012 ident: 10.1016/j.neo.2021.05.002_bib0017 article-title: Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1,2-dimethylhydrazine induced rat colon carcinogenesis publication-title: Environmental toxicol and pharmacol doi: 10.1016/j.etap.2012.07.014 – volume: 7 start-page: 19 year: 2012 ident: 10.1016/j.neo.2021.05.002_bib0046 article-title: Progress in research on correlation among STAT3, CyclinD1, P21 genes and tumors publication-title: Journal of Otol – volume: 44 start-page: 2121 year: 2014 ident: 10.1016/j.neo.2021.05.002_bib0009 article-title: TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells publication-title: Eur j immunol doi: 10.1002/eji.201344341 – volume: 30 start-page: 199 year: 2011 ident: 10.1016/j.neo.2021.05.002_bib0013 article-title: Antitumor initiating potential of rosmarinic acid in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis publication-title: J environmental pathol, toxicol and oncol: off organ of the Int Soc for Environmental Toxicol and Cancer doi: 10.1615/JEnvironPatholToxicolOncol.v30.i3.30 – volume: 4 start-page: 4 year: 2018 ident: 10.1016/j.neo.2021.05.002_bib0025 article-title: Assessing mucosal inflammation in a DSS-induced colitis mouse model by MR colonography publication-title: Tomography doi: 10.18383/j.tom.2017.00021 – volume: 28 start-page: 173 year: 2005 ident: 10.1016/j.neo.2021.05.002_bib0012 article-title: Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica publication-title: Biol & pharmaceutical bulletin doi: 10.1248/bpb.28.173 – volume: 94 start-page: 965 year: 2003 ident: 10.1016/j.neo.2021.05.002_bib0040 article-title: A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate publication-title: Cancer sci doi: 10.1111/j.1349-7006.2003.tb01386.x – volume: 47 start-page: 1399 year: 2018 ident: 10.1016/j.neo.2021.05.002_bib0054 article-title: Induction of Pro-Inflammatory Response via Activated Macrophage-Mediated NF-kappaB and STAT3 Pathways in Gastric Cancer Cells publication-title: Cellular physiol and biochemistry: int j experimental cellular physiology, biochemistry, and pharmacol doi: 10.1159/000490829 – volume: 11 start-page: 210 year: 2020 ident: 10.1016/j.neo.2021.05.002_bib0044 article-title: Life, death, and autophagy in cancer: NF-kappaB turns up everywhere publication-title: Cell death & dis doi: 10.1038/s41419-020-2399-y – volume: 31 start-page: 455 year: 2010 ident: 10.1016/j.neo.2021.05.002_bib0020 article-title: AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading publication-title: J Comput Chem doi: 10.1002/jcc.21334 – volume: 66 start-page: 7 year: 2016 ident: 10.1016/j.neo.2021.05.002_bib0001 article-title: Cancer statistics, 2016 publication-title: CA: a cancer j for clin – volume: 77 start-page: 1708 year: 2009 ident: 10.1016/j.neo.2021.05.002_bib0018 article-title: Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice publication-title: Infect Immun doi: 10.1128/IAI.00814-08 – volume: 3 start-page: 107 year: 2012 ident: 10.1016/j.neo.2021.05.002_bib0041 article-title: Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer publication-title: Frontiers in immunol doi: 10.3389/fimmu.2012.00107 – volume: 285 start-page: C399 year: 2003 ident: 10.1016/j.neo.2021.05.002_bib0055 article-title: Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages publication-title: Am J physiol Cell physiol doi: 10.1152/ajpcell.00026.2003 – volume: 44 start-page: 1032 year: 2014 ident: 10.1016/j.neo.2021.05.002_bib0045 article-title: The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (Review) publication-title: Int J Oncol doi: 10.3892/ijo.2014.2259 – volume: 287 start-page: G7 year: 2004 ident: 10.1016/j.neo.2021.05.002_bib0032 article-title: Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation publication-title: Am J physiol Gastrointestinal and liver physiol doi: 10.1152/ajpgi.00079.2004 – volume: 75 start-page: 14 year: 2015 ident: 10.1016/j.neo.2021.05.002_bib0034 article-title: Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-kappaB inactivation on colitis-associated colon tumorigenesis in mice publication-title: Food and chemical toxicol: an int J published for the Br Industrial Biol Res Assoc doi: 10.1016/j.fct.2014.11.007 – volume: 40 start-page: S150 issue: Suppl 3 year: 2006 ident: 10.1016/j.neo.2021.05.002_bib0036 article-title: The metabolism of mesalamine and its possible use in colonic diverticulitis as an anti-inflammatory agent publication-title: J clin gastroenterol doi: 10.1097/01.mcg.0000212654.28527.d0 – volume: 2 start-page: 98 year: 2011 ident: 10.1016/j.neo.2021.05.002_bib0008 article-title: Chronic inflammation in cancer development publication-title: Frontiers in immunol – volume: 8 start-page: 127 year: 1995 ident: 10.1016/j.neo.2021.05.002_bib0023 article-title: LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions publication-title: Protein Eng doi: 10.1093/protein/8.2.127 – volume: 82 start-page: 388 year: 2016 ident: 10.1016/j.neo.2021.05.002_bib0011 article-title: Rosmarinic acid–pharmaceutical and clinical aspects publication-title: Planta Med doi: 10.1055/s-0035-1568274 – volume: 11 start-page: 1003 year: 2006 ident: 10.1016/j.neo.2021.05.002_bib0039 article-title: Update on capecitabine in colorectal cancer publication-title: The oncol doi: 10.1634/theoncologist.11-9-1003 – volume: 17 start-page: 1464 year: 2011 ident: 10.1016/j.neo.2021.05.002_bib0006 article-title: Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis publication-title: Inflammatory bowel dis doi: 10.1002/ibd.21527 – volume: 15 start-page: 551 year: 2014 ident: 10.1016/j.neo.2021.05.002_bib0010 article-title: Signal transducer and activator of transcription 3 - a promising target in colitis-associated cancer publication-title: Asian Pacific j cancer prevention: APJCP doi: 10.7314/APJCP.2014.15.2.551 – volume: 378 start-page: 2081 year: 2011 ident: 10.1016/j.neo.2021.05.002_bib0033 article-title: Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(11)61049-0 – volume: 6 start-page: 17 issue: Suppl 4 year: 2001 ident: 10.1016/j.neo.2021.05.002_bib0037 article-title: Optimizing the use of irinotecan in colorectal cancer publication-title: The oncol doi: 10.1634/theoncologist.6-suppl_4-17 – volume: 14 start-page: 2592 year: 2010 ident: 10.1016/j.neo.2021.05.002_bib0051 article-title: Endogenous toll-like receptor ligands and their biological significance publication-title: J cellular and molecular med doi: 10.1111/j.1582-4934.2010.01127.x – volume: 2016 year: 2016 ident: 10.1016/j.neo.2021.05.002_bib0050 article-title: The role of toll-like receptor 4 in infectious and noninfectious inflammation publication-title: Mediators Inflamm doi: 10.1155/2016/6978936 – ident: 10.1016/j.neo.2021.05.002_bib0027 doi: 10.4066/biomedicalresearch.29-17-2928 – volume: 15 start-page: 1949 year: 2009 ident: 10.1016/j.neo.2021.05.002_bib0005 article-title: Inflammation, microenvironment, and the immune system in cancer progression publication-title: Curr Pharm Des doi: 10.2174/138161209788453167 – volume: 8 start-page: 33 year: 2009 ident: 10.1016/j.neo.2021.05.002_bib0042 article-title: Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls publication-title: Nature rev Drug discovery doi: 10.1038/nrd2781 – volume: 7 start-page: 46252 year: 2017 ident: 10.1016/j.neo.2021.05.002_bib0016 article-title: Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-kappaB and STAT3 activation publication-title: Scientific rep doi: 10.1038/srep46252 – ident: 10.1016/j.neo.2021.05.002_bib0003 doi: 10.1016/j.semcancer.2019.05.001 – volume: 17 start-page: 230 year: 2016 ident: 10.1016/j.neo.2021.05.002_bib0030 article-title: Inflammatory networks underlying colorectal cancer publication-title: Nature Immunol doi: 10.1038/ni.3384 |
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| SubjectTerms | Animals Biomarkers Cell Line, Tumor Cinnamates - chemistry Cinnamates - pharmacology Colitis-associated colon cancer (CAC) Colitis-Associated Neoplasms - drug therapy Colitis-Associated Neoplasms - etiology Colitis-Associated Neoplasms - metabolism Colitis-Associated Neoplasms - pathology Colonic Neoplasms - drug therapy Colonic Neoplasms - etiology Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Depsides - chemistry Depsides - pharmacology Disease Models, Animal Humans Immunohistochemistry Male Mice Models, Molecular Myeloid differentiation factor 2 (MD-2) NF-kappa B - metabolism Nuclear factor-kappa B (NF-κB) Original Research Rosmarinic Acid Rosmarinic acid (RA) Signal transducer and activator of transcription 3 (STAT3) Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Structure-Activity Relationship Toll-Like Receptor 4 - metabolism Toll-like receptor-4 (TLR4) Xenograft Model Antitumor Assays |
| Title | Rosmarinic acid represses colitis-associated colon cancer: A pivotal involvement of the TLR4-mediated NF-κB-STAT3 axis |
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