The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales

During the several-week course of an immune response, B cells undergo a process of clonal expansion, somatic hypermutation of the immunoglobulin (Ig) genes and affinity-dependent selection. Over a lifetime, each B cell may participate in multiple rounds of affinity maturation as part of different im...

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Bibliographic Details
Published in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 370; no. 1676
Main Authors:	Yaari, Gur, Benichou, Jennifer I C, Vander Heiden, Jason A, Kleinstein, Steven H, Louzoun, Yoram
Format:	Journal Article
Language:	English
Published:	England 05.09.2015
Subjects:	Antibody Affinity - genetics Antibody Diversity B-Lymphocytes - immunology Cell Lineage - genetics Cell Lineage - immunology Clonal Selection, Antigen-Mediated Complementarity Determining Regions Genes, Immunoglobulin Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Models, Genetic Models, Immunological Mutation Receptors, Antigen, B-Cell - genetics Somatic Hypermutation, Immunoglobulin Time Factors lineage trees mutations antigen-driven selection B-cell receptor next generation sequencing affinity maturation
ISSN:	1471-2970, 1471-2970
Online Access:	Get more information
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