SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19

Toll-like receptors (TLRs) play a pivotal role in the immunologic response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Exaggerated inflammatory response of innate immune cells, however, may drive morbidity and death in Coronavirus disease 19 (COVID-19). We investigated...

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Veröffentlicht in:	Heliyon Jg. 9; H. 11; S. e21893
Hauptverfasser:	Sahanic, Sabina, Hilbe, Richard, Dünser, Christina, Tymoszuk, Piotr, Löffler-Ragg, Judith, Rieder, Dietmar, Trajanoski, Zlatko, Krogsdam, Anne, Demetz, Egon, Yurchenko, Maria, Fischer, Christine, Schirmer, Michael, Theurl, Markus, Lener, Daniela, Hirsch, Jakob, Holfeld, Johannes, Gollmann-Tepeköylü, Can, Zinner, Carl P., Tzankov, Alexandar, Zhang, Shen-Ying, Casanova, Jean-Laurent, Posch, Wilfried, Wilflingseder, Doris, Weiss, Guenter, Tancevski, Ivan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.11.2023 Elsevier
Schlagworte:	COVID-19 COVID-19 infection CRISPR-Cas systems death domain genes humans immune response inflammation Innate immunity interferons lungs Macrophages morbidity SARS-CoV-2 sequence analysis Severe acute respiratory syndrome coronavirus 2 therapeutics Toll-like receptors transcriptomics COVID-19 Toll-like receptors Innate immunity SARS-CoV-2 Macrophages
ISSN:	2405-8440, 2405-8440
Online-Zugang:	Volltext
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