Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era

•Pediatric low-grade glioma (pLGG) is a MAPK pathway-altered disease with novel therapeutic options.•Clinical trials are vital in translation of targeted agents to influence patient care.•Targeted agents have unknown long-term toxicities and unclear impact on pLGG natural history.•Challenges include...

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Bibliographic Details
Published in:	Neoplasia (New York, N.Y.) Vol. 36; p. 100857
Main Authors:	Manoharan, Neevika, Liu, Kevin X., Mueller, Sabine, Haas-Kogan, Daphne A., Bandopadhayay, Pratiti
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2023 Neoplasia Press Elsevier
Subjects:	BRAF Brain Neoplasms - drug therapy Brain Neoplasms - genetics Child Clinical Trials as Topic Glioma - diagnosis Glioma - drug therapy Glioma - genetics Humans MAPK mTOR Original Research pLGG Targeted therapy WES Targeted therapy IHC pLGG RTK TPCV CNS GNT mTOR DNET PFS PLNTY WHO RAPNO OS TSC BRAF MAPK FGFR DNA PNOC FISH NF1 JPA CPK
ISSN:	1476-5586, 1522-8002, 1476-5586
Online Access:	Get full text
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