Post-translational modifications of tubulin: pathways to functional diversity of microtubules

•Tubulin modifications contribute to functional diversity of microtubules (MTs).•Post-translational modifications (PTMs) affect MT dynamics, organization, and interactions with other cellular components.•Various PTMs overlap or localize to specific MT domains demonstrating heterogeneity.•PTMs vary w...

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Published in:	Trends in cell biology Vol. 25; no. 3; pp. 125 - 136
Main Authors:	Song, Yuyu, Brady, Scott T.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.03.2015
Subjects:	acetylation Animals detyrosination Humans microtubule Microtubules - metabolism Pathology polyamination polyglutamylation Protein Processing, Post-Translational tubulin Tubulin - metabolism microtubule acetylation tubulin polyglutamylation polyamination detyrosination
ISSN:	0962-8924, 1879-3088, 1879-3088
Online Access:	Get full text
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Abstract	•Tubulin modifications contribute to functional diversity of microtubules (MTs).•Post-translational modifications (PTMs) affect MT dynamics, organization, and interactions with other cellular components.•Various PTMs overlap or localize to specific MT domains demonstrating heterogeneity.•PTMs vary with time, cell type, subcellular compartment, and physiological state. Tubulin and microtubules are subject to a remarkable number of post-translational modifications. Understanding the roles these modifications play in determining the functions and properties of microtubules has presented a major challenge that is only now being met. Many of these modifications are found concurrently, leading to considerable diversity in cellular microtubules, which varies with development, differentiation, cell compartment, and cell cycle. We now know that post-translational modifications of tubulin affect, not only the dynamics of the microtubules, but also their organization and interaction with other cellular components. Many early suggestions of how post-translational modifications affect microtubules have been replaced with new ideas and even new modifications as our understanding of cellular microtubule diversity comes into focus.
AbstractList	Tubulin and microtubules are subject to a remarkable number of post-translational modifications. Understanding the roles these modifications play in determining the functions and properties of microtubules has presented a major challenge that is only now being met. Many of these modifications are found concurrently, leading to considerable diversity in cellular microtubules, which varies with development, differentiation, cell compartment, and cell cycle. We now know that post-translational modifications of tubulin affect, not only the dynamics of the microtubules, but also their organization and interaction with other cellular components. Many early suggestions of how post-translational modifications affect microtubules have been replaced with new ideas and even new modifications as our understanding of cellular microtubule diversity comes into focus.Tubulin and microtubules are subject to a remarkable number of post-translational modifications. Understanding the roles these modifications play in determining the functions and properties of microtubules has presented a major challenge that is only now being met. Many of these modifications are found concurrently, leading to considerable diversity in cellular microtubules, which varies with development, differentiation, cell compartment, and cell cycle. We now know that post-translational modifications of tubulin affect, not only the dynamics of the microtubules, but also their organization and interaction with other cellular components. Many early suggestions of how post-translational modifications affect microtubules have been replaced with new ideas and even new modifications as our understanding of cellular microtubule diversity comes into focus. Highlights • Tubulin modifications contribute to functional diversity of microtubules (MTs). • Post-translational modifications (PTMs) affect MT dynamics, organization, and interactions with other cellular components. • Various PTMs overlap or localize to specific MT domains demonstrating heterogeneity. • PTMs vary with time, cell type, subcellular compartment, and physiological state. •Tubulin modifications contribute to functional diversity of microtubules (MTs).•Post-translational modifications (PTMs) affect MT dynamics, organization, and interactions with other cellular components.•Various PTMs overlap or localize to specific MT domains demonstrating heterogeneity.•PTMs vary with time, cell type, subcellular compartment, and physiological state. Tubulin and microtubules are subject to a remarkable number of post-translational modifications. Understanding the roles these modifications play in determining the functions and properties of microtubules has presented a major challenge that is only now being met. Many of these modifications are found concurrently, leading to considerable diversity in cellular microtubules, which varies with development, differentiation, cell compartment, and cell cycle. We now know that post-translational modifications of tubulin affect, not only the dynamics of the microtubules, but also their organization and interaction with other cellular components. Many early suggestions of how post-translational modifications affect microtubules have been replaced with new ideas and even new modifications as our understanding of cellular microtubule diversity comes into focus. Tubulin and microtubules are subject to a remarkable number of post-translational modifications. Understanding the roles these modifications play in determining the functions and properties of microtubules has presented a major challenge that is only now being met. Many of these modifications are found concurrently, leading to considerable diversity in cellular microtubules, which varies with development, differentiation, cell compartment, and cell cycle. We now know that post-translational modifications of tubulin affect, not only the dynamics of the microtubules, but also their organization and interaction with other cellular components. Many early suggestions of how post-translational modifications affect microtubules have been replaced with new ideas and even new modifications as our understanding of cellular microtubule diversity comes into focus.
Author	Song, Yuyu Brady, Scott T.
Author_xml	– sequence: 1 givenname: Yuyu surname: Song fullname: Song, Yuyu organization: Yale School of Medicine, Department of Genetics and Howard Hughes Medical Institute, Boyer Center, 295 Congress Avenue, New Haven, CT 065105, USA – sequence: 2 givenname: Scott T. surname: Brady fullname: Brady, Scott T. email: stbrady@uic.edu organization: Department of Anatomy and Cell Biology, 808 S. Wood St., Rm 578 (M/C 512), University of Illinois at Chicago, Chicago, IL 60612, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25468068$$D View this record in MEDLINE/PubMed
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Snippet	•Tubulin modifications contribute to functional diversity of microtubules (MTs).•Post-translational modifications (PTMs) affect MT dynamics, organization, and... Highlights • Tubulin modifications contribute to functional diversity of microtubules (MTs). • Post-translational modifications (PTMs) affect MT dynamics,... Tubulin and microtubules are subject to a remarkable number of post-translational modifications. Understanding the roles these modifications play in...
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SubjectTerms	acetylation Animals detyrosination Humans microtubule Microtubules - metabolism Pathology polyamination polyglutamylation Protein Processing, Post-Translational tubulin Tubulin - metabolism
Title	Post-translational modifications of tubulin: pathways to functional diversity of microtubules
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