The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

Signal transducer and activator of transcription (STAT) proteins communicate from cell-surface receptors to drive transcription of immune response genes. The parasite Toxoplasma gondii blocks STAT1-mediated gene expression by secreting the intrinsically disordered protein TgIST that traffics to the...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 4047 - 15
Main Authors:	Huang, Zhou, Liu, Hejun, Nix, Jay, Xu, Rui, Knoverek, Catherine R., Bowman, Gregory R., Amarasinghe, Gaya K., Sibley, L. David
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.07.2022 Nature Publishing Group Nature Portfolio
Subjects:	101/58 13/109 13/31 14/5 631/250/2499 631/250/516 631/326/417/2547 631/535/1266 82/103 9/10 Antimicrobial responses BASIC BIOLOGICAL SCIENCES Binding Blocking Cell surface Cellular structure Dimerization Dimers Gene expression Genes Grooves Humanities and Social Sciences Immune response Immune system Interferon Interferon-gamma - metabolism Intrinsically Disordered Proteins - genetics Intrinsically Disordered Proteins - metabolism multidisciplinary Parasite immune evasion Parasites Phosphorylation Proteins Recruitment Science Science (multidisciplinary) Signal Transduction src Homology Domains Stat1 protein STAT1 Transcription Factor - metabolism Toxoplasma Toxoplasma gondii Transcription Transcription factors X-ray crystallography
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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